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Estrace Cost, Generic and Savings
- Lowest price per tablet at U.S. online pharmacies
- $0.12 per tabletIn a pack of 180 tablets for $21.60 (before shipping) · FDA-approved generic estradiol 1 mg · ships within the U.S.
- Lowest price per tablet at online pharmacies abroad
- $0.55 per tabletIn a pack of 100 tablets for $55 (before shipping) · generic estradiol 1 mg, not FDA-approved · ships from Canada
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Quick answerAs of Nov 11, 2026, generic estradiol 1 mg (generic Estrace) costs from $0.55 per tablet at pharmacies we compared, before shipping. Brand Estrace tablets are discontinued in the U.S. FDA-approved generic estradiol tablets are sold here, with list prices from $8.70 for 100 tablets of 1 mg.
Name check: Estrace vaginal cream is still sold in the U.S. by AbbVie. It's a different product, so this page covers only the tablets.
Compare Estrace prices from licensed online pharmacies
| Pharmacy | Medication | Pack | Price per unit | Pack price | Shipping & delivery | Total with shipping | Buy |
|---|---|---|---|---|---|---|---|
| Lowest price per unitLicensed U.S. pharmacy A | Estradiol (Estrace)2 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 270 tablets4 other pack sizes
| $0.12 per tablet | $32 | $5Pharmacy's estimate: 7–10 business days | $37Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy B | Estradiol 1mg Tablets1 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 180 tablets4 other pack sizes
| $0.12 per tablet | $21.60 | $5Pharmacy's estimate: 2–8 business days | $26.60Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy A | Estradiol (Estrace)1 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 270 tablets4 other pack sizes
| $0.14 per tablet | $36.68 | $5Pharmacy's estimate: 7–10 business days | $41.68Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy A | Estradiol (Estrace)0.5 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 270 tablets4 other pack sizes
| $0.14 per tablet | $37.35 | $5Pharmacy's estimate: 7–10 business days | $42.35Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy C | Estradiol 0.5mg Tablet0.5 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 360 tablets2 other pack sizes
| $0.19 per tablet | $70 | FreePharmacy's estimate: 3–5 business days | $70Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy C | Estradiol 1mg Tablet1 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 360 tablets2 other pack sizes
| $0.19 per tablet | $70 | FreePharmacy's estimate: 3–5 business days | $70Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy C | Estradiol 2mg Tablet2 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 360 tablets2 other pack sizes
| $0.19 per tablet | $70 | FreePharmacy's estimate: 3–5 business days | $70Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.0.5 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.21 per tablet | $21.15 | Fee not publishedDelivery time not stated | $21.15+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.0.5 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.32 per tablet | $31.99 | Fee not publishedDelivery time not stated | $31.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.1 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.33 per tablet | $32.76 | Fee not publishedDelivery time not stated | $32.76+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.0.5 mg · generic · Filled in CanadaMaker listed by pharmacy: Lupin Ltd | 100 tablets | $0.35 per tablet | $35 | $9.95Pharmacy's estimate: 4–6 weeks | $44.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.1 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.44 per tablet | $43.99 | Fee not publishedDelivery time not stated | $43.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy G | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.0.5 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.45 per tablet | $44.56 | $9.95Delivery time not stated | $54.51Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.2 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.51 per tablet | $51.21 | Fee not publishedDelivery time not stated | $51.21+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed Canadian pharmacy H | Lupin EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.0.5 mg · generic · Filled in CanadaMaker listed by pharmacy: LUPIN PHARMA CANADA LIMITED | 100 tablets | $0.52 per tablet | $51.79 | $9.95Pharmacy's estimate: 3–6 weeks | $61.74Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.1 mg · generic · Filled in CanadaMaker listed by pharmacy: Lupin Ltd | 100 tablets | $0.55 per tablet | $55 | $9.95Pharmacy's estimate: 4–6 weeks | $64.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy I | ESTRADIOL (EU pack, ships from Canada)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.0.5 mg · generic · Filled in CanadaProduct of EU | 100 tablets | $0.57 per tablet | $57.06 | FreeDelivery time not stated | $57.06Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy G | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.1 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.61 per tablet | $61.48 | $9.95Delivery time not stated | $71.43Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed Canadian pharmacy H | Lupin EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.1 mg · generic · Filled in CanadaMaker listed by pharmacy: LUPIN PHARMA CANADA LIMITED | 100 tablets | $0.62 per tablet | $61.71 | $9.95Pharmacy's estimate: 3–6 weeks | $71.66Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.2 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.62 per tablet | $61.99 | Fee not publishedDelivery time not stated | $61.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy J | Lupin Estradiol (Estradiol)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.0.5 mg · generic · Filled in CanadaMaker listed by pharmacy: Laboratoire Riva Inc. | 100 tablets | $0.68 per tablet | $67.74 | FreePharmacy's estimate: 2–3 weeks | $67.74Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.2 mg · generic · Filled in CanadaMaker listed by pharmacy: Lupin Ltd | 100 tablets | $0.69 per tablet | $69 | $9.95Pharmacy's estimate: 4–6 weeks | $78.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed Canadian pharmacy H | Lupin EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.2 mg · generic · Filled in CanadaMaker listed by pharmacy: LUPIN PHARMA CANADA LIMITED | 100 tablets | $0.85 per tablet | $84.87 | $9.95Pharmacy's estimate: 3–6 weeks | $94.82Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy J | Lupin Estradiol (Estradiol)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.1 mg · generic · Filled in CanadaMaker listed by pharmacy: Laboratoire Riva Inc. | 100 tablets | $0.94 per tablet | $93.99 | FreePharmacy's estimate: 2–3 weeks | $93.99Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy G | EstradiolNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.2 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.95 per tablet | $94.60 | $9.95Delivery time not stated | $104.55Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy J | Lupin Estradiol (Estradiol)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.2 mg · generic · Filled in CanadaMaker listed by pharmacy: Laboratoire Riva Inc. | 100 tablets | $1.20 per tablet | $120.24 | FreePharmacy's estimate: 2–3 weeks | $120.24Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy KU.S. shipping limited | Estradiol (Generic)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.0.5 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.50 per tablet | $50 | $14.95Pharmacy's estimate: 8–14 business days | $64.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy KU.S. shipping limited | Estradiol (Generic)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.1 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.60 per tablet | $60 | $14.95Pharmacy's estimate: 8–14 business days | $74.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy KU.S. shipping limited | Estradiol (Generic)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.2 mg · generic · Filled in CanadaProduct of Canada | 100 tablets | $0.81 per tablet | $81 | $14.95Pharmacy's estimate: 8–14 business days | $95.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Estrace from Canada?
| Strength | Lowest brandper unit, before shipping | Lowest generic abroadper unit, not FDA-approved |
|---|---|---|
| Estrace 0.5 mg | — | $0.35 per tablet |
| Estrace 1 mg | — | $0.55 per tablet |
| Estrace 2 mg | — | $0.69 per tablet |
Each row is one product from one pharmacy, shown in the pack size with the lowest price per unit; its other pack sizes are listed under “other pack sizes”. Price per unit = the pack price divided by the units in the pack, before shipping; we sort by it and don't assume how long a pack lasts. Total with shipping = the pack price plus the pharmacy's shipping fee for one order. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars (converted when a pharmacy prices in Canadian dollars). The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, plus its standard shipping; no insurance or discount cards. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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Prices per tablet from 5 licensed pharmacies abroad shipping to the U.S.: $0.35 to $1.20, any strength, before shipping.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Estrace · Similar drugs · Uses · FAQ
Estrace (estradiol) tablets treat menopause symptoms. The brand tablets are discontinued in the U.S.; FDA-approved generic estradiol is sold.
Estrace cost at a glance
- Brand Estrace tablets are discontinued in the U.S. The FDA's Drugs@FDA database lists Estrace 0.5 mg, 1 mg and 2 mg tablets as discontinued, and the FDA has determined they were not withdrawn for safety or effectiveness reasons (Drugs@FDA, checked 2026-11-11).
- Generic Estrace is sold in the U.S. The FDA has approved generic estradiol tablets (0.5, 1 and 2 mg) from several companies, rated equivalent (FDA Orange Book). Epic Pharma's 2026 U.S. list prices for 100 tablets are $7.24 (0.5 mg), $8.70 (1 mg) and $13.80 (2 mg) (Texas DSHS).
- U.S. list price for the brand tablets: there isn't one, because brand Estrace tablets are no longer sold here. Generic list prices are shown above.
- How we count: prices are per tablet, with each pharmacy's packs listed as sold. The label sets the dose for each use: for menopause symptoms it usually starts at 1 to 2 mg a day, often taken in cycles (for example, 3 weeks on and 1 week off).
- From pharmacies we compared: $0.55 to $0.94 per tablet for generic estradiol 1 mg, before shipping (checked Nov 11, 2026). Packs made for other countries are not FDA-approved.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Estrace cost in the U.S.?
| If you have | What Estrace costs | Source |
|---|---|---|
| No insurance (brand list price) | None. The FDA lists brand Estrace tablets as discontinued in the U.S. FDA-approved generic tablets are sold here; see the next row. | Drugs@FDA |
| No insurance (generic estradiol) | FDA-approved generic estradiol tablets are sold in the U.S. Epic Pharma lists 100 tablets at $7.24 (0.5 mg), $8.70 (1 mg) and $13.80 (2 mg); Teva lists 100 tablets of 1 mg at $30.74. Ask your pharmacist for the cash price. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan's drug list. Ask your plan or pharmacist what you'd pay for generic estradiol tablets. | FDA Orange Book |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
The FDA lists brand Estrace tablets as discontinued in the U.S. (Drugs@FDA), so this page shows no U.S. list price for them. FDA-approved generic estradiol tablets have been sold here for decades. In 2026, a bottle of 100 generic 1 mg tablets lists at $8.70 from Epic Pharma and $30.74 from Teva (Texas DSHS). List prices are the maker's wholesale price before discounts; what a pharmacy charges can differ.
Estrace cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for generic estradiol tablets depends on your plan's drug list.
| Medicare Part D | What Estrace costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Estrace coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
eDrugSearch does not offer its own Estrace coupons. These programs can help with the cost of generic estradiol:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Estrace?
Yes. The FDA has approved generic estradiol tablets in 0.5 mg, 1 mg and 2 mg from several companies, including Teva (Barr), Epic Pharma and Novitium, all rated equivalent. Teva's has been listed as on the U.S. market since October 28, 1997. The FDA lists brand Estrace tablets as discontinued in the U.S.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 0.5 mg | Yes | Teva (Barr), Epic Pharma, Novitium | — |
| 1 mg | Yes | Teva (Barr), Epic Pharma, Novitium | Oct 28, 1997 |
| 2 mg | Yes | Teva (Barr), Epic Pharma, Novitium | — |
Outside the U.S.: Online pharmacies abroad may also sell estradiol tablets made for other markets, sometimes under other brand names. Those packs are not FDA-approved, and the price table labels them that way.
Source: FDA Orange Book: estradiol tablets. As of Nov 11, 2026.
Compare Estrace with similar drugs
Other menopause hormone medicines people often compare with Estrace, such as Premarin, Prempro, Activella and the Estring vaginal ring. Each is a different product, and your prescriber decides which medicine is right for you. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Premproconjugated estrogens and medroxyprogesterone | Menopause hormone therapy (estrogen plus progestin) | From $1.37 per tablet | See prices |
| Premarinconjugated estrogens | Estrogen hormone therapy for menopause symptoms (conjugated estrogens tablets) | From $0.64 per tablet | See prices |
| Activellaestradiol and norethindrone acetate | Menopause hormone therapy (estrogen plus progestin) | From $0.97 per tablet | See prices |
| Estringestradiol | Vaginal estrogen for menopause symptoms (estradiol vaginal ring) | From $129.00 per ring | See prices |
Lowest price per unit, before shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Estrace used for?
Estrace (estradiol) is an estrogen, the main female hormone the ovaries make before menopause. According to the FDA label for estradiol tablets (DailyMed), they are used:
- To treat moderate to severe hot flashes and night sweats from menopause.
- To treat moderate to severe vaginal dryness and irritation from menopause (the label says vaginal products should be considered when that's the only symptom).
- To treat low estrogen caused by underactive ovaries, removal of the ovaries or ovarian failure.
- To ease symptoms of some advanced breast cancers in women and men, and of advanced prostate cancer (palliation only).
- To help prevent osteoporosis after menopause, in women at significant risk who can't use non-estrogen medicines.
The label says to use the lowest dose that works for the shortest time needed, and that women who still have a uterus should also take a progestin to lower the risk of endometrial cancer. Boxed warning: the label carries the FDA's strongest warning. Estrogens raise the risk of endometrial cancer, and in a large study (the Women's Health Initiative) estrogen plus progestin raised the risk of heart attack, stroke, breast cancer, blood clots and, in women 65 and older, probable dementia. Estrogens should not be used to prevent heart disease. Your prescriber decides which medicine is right for you.
Is it safe to order Estrace from Canada?
Many Americans do, but U.S. law and customs rules apply, and for estradiol, compare the U.S. price of FDA-approved generic tablets before you order. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, brand Estrace tablets were cancelled in 1998 and 1999 (Health Canada).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Estrace without insurance?
Brand Estrace tablets are discontinued in the U.S., so there's no current U.S. list price for them. FDA-approved generic estradiol tablets are sold here: in 2026, 100 tablets of 1 mg list at $8.70 (Epic Pharma) and $30.74 (Teva) (makers' list prices before discounts). Pharmacies we compared charged from $0.55 per tablet for generic estradiol 1 mg in our latest check (Nov 11, 2026), before shipping.
Is there a generic Estrace?
Yes. The FDA has approved generic estradiol tablets in 0.5 mg, 1 mg and 2 mg from several companies, rated equivalent. Teva's has been on the U.S. market since 1997. The generic name is estradiol. Ask your pharmacist whether a generic can fill your prescription.
Was Estrace discontinued?
Brand Estrace tablets, yes. The FDA's Drugs@FDA database lists them as discontinued in the U.S., and the FDA has determined they weren't withdrawn for safety or effectiveness reasons. Estrace vaginal cream is still sold, and generic estradiol tablets are widely available.
Is Estrace cream the same as Estrace tablets?
No. Both contain estradiol, but the cream is used in the vagina and the tablets are swallowed. They're separate products with separate prices. AbbVie's Estrace cream has a 2026 U.S. list price of $344.78 a tube. This page covers only the tablets. Your prescriber decides which medicine is right for you.
Is there an Estrace coupon or savings card?
eDrugSearch doesn't offer coupons of its own. Brand Estrace tablets are discontinued in the U.S., and generic estradiol has low list prices; ask your pharmacist for the cash price. If you have Medicare and limited income, Extra Help can lower what you pay for prescriptions.
How much does estradiol cost with Medicare?
It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. Ask your plan how it covers generic estradiol tablets. People with limited income can apply for Extra Help.
What strengths do estradiol tablets come in?
Generic estradiol tablets come in 0.5 mg, 1 mg and 2 mg, usually in bottles of 100. Brand Estrace came in the same three strengths before it was discontinued in the U.S.
Sources
- Drugs@FDA: Estrace tablets (ANDA 084499, 084500, 081295) (1 mg, 2 mg and 0.5 mg tablets Discontinued, with a Federal Register determination that they were not discontinued or withdrawn for safety or effectiveness reasons)
- Estradiol tablets U.S. prescribing information (DailyMed) (Epic Pharma, label version 13, effective February 26, 2026 (generic estradiol tablets, ANDA 040275))
- Texas DSHS: 2026 annual WAC report (generic estradiol tablet list prices (Epic Pharma 42806008701/8801/8901; Teva 00555089902/088602/088702); Estrace cream 00430375414 $344.78)
- FDA Orange Book: estradiol tablets
- FDA NDC Directory: Teva estradiol 1 mg (NDC 0555-0886) (ANDA 040197, marketing start October 28, 1997)
- FDA NDC Directory: Epic Pharma estradiol 1 mg (NDC 42806-088) (ANDA 040275, marketing start April 10, 2017)
- Health Canada Drug Product Database: Estrace (Bristol-Myers Squibb; 1 mg (DIN 00464791) cancelled 1999-01-07; 2 mg (DIN 00464805) cancelled 1998-04-07)
- ESTRACE cream U.S. prescribing information (DailyMed) (Allergan (AbbVie), separate vaginal cream product)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.