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Activella Cost, Coupons and Generic
- U.S. list price
- $903.06 for 90 days (90 tablets)The maker's price for brand Activella before discounts · Source: Texas DSHS 2026 WAC report
- Lowest international online pharmacy price
- $0.48 per tablet$43.03 for 90 days (90 tablets), plus shipping (fee not published) · brand Activella 1 mg/0.5 mg, not FDA-approved · ships from United Kingdom
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Quick answerAs of Nov 11, 2026, brand Activella 1/0.5 mg costs from $89.98 for 90 days at licensed pharmacies abroad we compared, vs. about $903.05 at the U.S. list price ($280.95 per 28 tablets). FDA-approved generics are sold in the U.S.; Xiromed lists 84 tablets at $44.11.
Name check: Outside the U.S., Novo Nordisk sells this medicine as Activelle (and Activelle LD for the 0.5/0.1 mg strength). The price table labels those packs with the name they're sold under.
Compare Activella prices from licensed online pharmacies
For comparison U.S. pharmacy list price: $903.06 for 90 days ($10.03 per tablet), brand Activella 1 mg/0.5 mg before insurance. The prices below are from U.S. pharmacies that publish cash prices and from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per tabletOnline pharmacy A | Kliovance (UK/EU pack, ships from United Kingdom) (sold outside the U.S. as Kliovance, Novo Nordisk)1 mg/0.5 mg · brand · Filled in United KingdomProduct of UK/EU | $40.16for 84 tablets$0.48 per tablet | Fee not publishedDelivery time not stated | $40.16 for 84 days= $43.03 for 90 days+ shippingSave 95%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy B | Kliovance (UK/EU pack, ships from United Kingdom) (sold outside the U.S. as Kliovance, Novo Nordisk)1 mg/0.5 mg · brand · Filled in United KingdomProduct of UK/EU | $50.99for 84 tablets$0.61 per tablet | Fee not publishedDelivery time not stated | $50.99 for 84 days= $54.63 for 90 days+ shippingSave 94%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | Activelle (Estradiol, Norethindrone Acetate) (Turkey pack, ships from Mauritius) (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in MauritiusMaker listed by pharmacy: Novo NordiskMade for Turkey | $83.98for 84 tablets$1.00 per tablet | FreePharmacy's estimate: 2–3 weeks | $83.98 for 84 days= $89.98 for 90 daysSave 90%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy D | ACTIVELLA (EU pack, ships from Mauritius)1 mg/0.5 mg · brand · Filled in MauritiusProduct of EU | $85.72for 84 tablets$1.02 per tablet | FreeDelivery time not stated | $85.72 for 84 days= $91.84 for 90 daysSave 90%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy E | Kliovance (UK/EU pack, ships from United Kingdom) (sold outside the U.S. as Kliovance, Novo Nordisk)1 mg/0.5 mg · brand · Filled in United KingdomProduct of UK/EU | $81.13for 84 tablets$0.97 per tablet | $9.95Delivery time not stated | $91.08 for 84 days= $97.59 for 90 daysSave 89%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy D | ACTIVELLA1 mg/0.5 mg · brand · Filled in UKProduct of UK | $92.84for 84 tablets$1.11 per tablet | FreeDelivery time not stated | $92.84 for 84 days= $99.47 for 90 daysSave 89%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy F | ACTIVELLA1 mg/0.5 mg · brand · Filled in United KingdomProduct of United Kingdom | $95.23for 84 tablets$1.13 per tablet | FreeDelivery time not stated | $95.23 for 84 days= $102.03 for 90 daysSave 89%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy G | Estradiol/Norethindrone Acetate 1-0.5mg Tablets - 28 Tablet Pack1 mg/0.5 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $99for 84 tablets$1.18 per tablet | $5Pharmacy's estimate: 2–8 business days | $104 for 84 days= $111.43 for 90 daysSave 88%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy H | ACTIVELLA 1MG/0.5MG TABLET 84 (ACTIVELLE BRAND FROM TURKEY) (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in TurkeyMade for sale in Turkey.Product of Turkey | $90for 84 tablets$1.07 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $104.95 for 84 days= $112.45 for 90 daysSave 88%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy H | ACTIVELLA 1MG/0.5MG TABLET 84 (KLIOVANCE BRAND FROM UK) (sold outside the U.S. as Kliovance, Novo Nordisk)1 mg/0.5 mg · brand · Filled in UKProduct of UK | $100for 84 tablets$1.19 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $114.95 for 84 days= $123.16 for 90 daysSave 86%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed online pharmacy I | Activella 1/0.5mg1 mg/0.5 mg · brand · Filled in United KingdomProduct of United Kingdom | $117for 84 tablets$1.39 per tablet | FreeDelivery time not stated | $117 for 84 days= $125.36 for 90 daysSave 86%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy J | Activelle (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in New ZealandMaker listed by pharmacy: Novo Nordisk | $108for 84 tablets$1.29 per tablet | $9.95Pharmacy's estimate: 4–6 weeks | $117.95 for 84 days= $126.38 for 90 daysSave 86%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy D | ACTIVELLA (EU pack, ships from New Zealand)1 mg/0.5 mg · brand · Filled in New ZealandProduct of EU | $124.47for 84 tablets$1.48 per tablet | FreeDelivery time not stated | $124.47 for 84 days= $133.36 for 90 daysSave 85%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy F | ACTIVELLA1 mg/0.5 mg · brand · Filled in New ZealandProduct of New Zealand | $126.86for 84 tablets$1.51 per tablet | FreeDelivery time not stated | $126.86 for 84 days= $135.92 for 90 daysSave 85%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | Kliovance (Estradiol, Norethindrone Acetate) (sold outside the U.S. as Kliovance, Novo Nordisk)1 mg/0.5 mg · brand · Filled in New ZealandMaker listed by pharmacy: Novo Nordisk | $130.74for 84 tablets$1.56 per tablet | FreePharmacy's estimate: 2–3 weeks | $130.74 for 84 days= $140.08 for 90 daysSave 84%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy K | Norethindrone Acet/Estradiol (Activella • [Generic])0.5 mg/0.1 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $132for 84 tablets$1.57 per tablet | FreePharmacy's estimate: 7–10 business days | $132 for 84 days= $141.43 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy H | ACTIVELLA 1MG/0.5MG TABLET 84 (KLIOVANCE BRAND FROM NEW ZEALAND) (sold outside the U.S. as Kliovance, Novo Nordisk)1 mg/0.5 mg · brand · Filled in New ZealandProduct of New Zealand | $146.25for 84 tablets$1.74 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $161.20 for 84 days= $172.71 for 90 daysSave 81%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy L | Activella (Turkey pack, ships from Mauritius)1 mg/0.5 mg · brand · Filled in MauritiusMaker listed by pharmacy: Novo NordiskMade for Turkey | $146.83for 84 tablets$1.75 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $161.78 for 84 days= $173.34 for 90 daysSave 81%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy L | Kliovance (sold outside the U.S. as Kliovance, Novo Nordisk)1 mg/0.5 mg · brand · Filled in New ZealandMaker listed by pharmacy: Novo Nordisk | $170.28for 84 tablets$2.03 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $185.23 for 84 days= $198.46 for 90 daysSave 78%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy J | Activelle (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in CanadaMaker listed by pharmacy: Novo Nordisk | $264for 84 tablets$3.14 per tablet | $9.95Pharmacy's estimate: 4–6 weeks | $273.95 for 84 days= $293.52 for 90 daysSave 67%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy J | Activelle LD (sold outside the U.S. as Activelle, Novo Nordisk)0.5 mg/0.1 mg · brand · Filled in CanadaMaker listed by pharmacy: Novo Nordisk | $267for 84 tablets$3.18 per tablet | $9.95Pharmacy's estimate: 4–6 weeks | $276.95 for 84 days= $296.73 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | Activelle (Estradiol, Norethindrone Acetate) (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in CanadaMaker listed by pharmacy: Novo Nordisk | $310.73for 84 tablets$3.70 per tablet | FreePharmacy's estimate: 2–3 weeks | $310.73 for 84 days= $332.93 for 90 daysSave 63%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | Activelle LD (Estradiol, Norethindrone Acetate) (sold outside the U.S. as Activelle, Novo Nordisk)0.5 mg/0.1 mg · brand · Filled in CanadaMaker listed by pharmacy: Novo Nordisk | $326.48for 84 tablets$3.89 per tablet | FreePharmacy's estimate: 2–3 weeks | $326.48 for 84 days= $349.80 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed Canadian pharmacy M | Activelle (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in CanadaMaker listed by pharmacy: Novo Nordisk Canada Inc. | $321.27for 84 tablets$3.82 per tablet | $9.95Pharmacy's estimate: 3–6 weeks | $331.22 for 84 days= $354.88 for 90 daysSave 61%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed Canadian pharmacy M | Activelle LD (sold outside the U.S. as Activelle, Novo Nordisk)0.5 mg/0.1 mg · brand · Filled in CanadaMaker listed by pharmacy: Novo Nordisk Canada Inc. | $337.81for 84 tablets$4.02 per tablet | $9.95Pharmacy's estimate: 3–6 weeks | $347.76 for 84 days= $372.60 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed Canadian pharmacy I | Activella 0.5/0.1mg0.5 mg/0.1 mg · brand · Filled in CanadaProduct of Canada | $376for 84 tablets$4.48 per tablet | FreeDelivery time not stated | $376 for 84 days= $402.86 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy D | ACTIVELLA (EU pack, ships from Canada)0.5 mg/0.1 mg · brand · Filled in CanadaProduct of EU | $425.42for 84 tablets$5.06 per tablet | FreeDelivery time not stated | $425.42 for 84 days= $455.81 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy F | ACTIVELLA0.5 mg/0.1 mg · brand · Filled in CanadaProduct of Canada | $427.81for 84 tablets$5.09 per tablet | FreeDelivery time not stated | $427.81 for 84 days= $458.37 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy L | Activelle (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in CanadaMaker listed by pharmacy: Novo Nordisk | $448.88for 84 tablets$5.34 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $463.83 for 84 days= $496.96 for 90 daysSave 45%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy D | ACTIVELLE (EU pack, ships from Canada) (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in CanadaProduct of EU | $167.48per 28 tablets · 3 packs = $502.44$5.98 per tablet | FreeDelivery time not stated | $502.44 for 84 days= $538.33 for 90 daysSave 40%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy H | ACTIVELLA 0.5/0.1MG TABLET 84 (ACTIVELLE BRAND FROM CANADA) (sold outside the U.S. as Activelle, Novo Nordisk)0.5 mg/0.1 mg · brand · Filled in CanadaProduct of Canada | $505for 84 tablets$6.01 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $519.95 for 84 days= $557.09 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy NU.S. shipping limited | Activella (Estradiol & Norethindrone) - Known as Activelle Internationally (sold outside the U.S. as Activelle, Novo Nordisk)1 mg/0.5 mg · brand · Filled in TurkeyMade for sale in Turkey.Product of Turkey | $118for 84 tablets$1.40 per tablet | $14.95Pharmacy's estimate: 8–14 business days | $132.95 for 84 days= $142.45 for 90 daysSave 84%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy NU.S. shipping limited | Activella (Estradiol & Norethindrone) - Known as Activelle LD Internationally (sold outside the U.S. as Activelle, Novo Nordisk)0.5 mg/0.1 mg · brand · Filled in CanadaProduct of Canada | $323for 84 tablets$3.85 per tablet | $14.95Pharmacy's estimate: 8–14 business days | $337.95 for 84 days= $362.09 for 90 daysWorked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Activella from Canada?
90-day cost = 90 tablets at the usual dose of 1 a day, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price of the same strength (1 mg/0.5 mg); rows for other strengths show no saving. The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, for whole fills, plus its standard shipping; no insurance or discount cards. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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Join to See PharmaciesAlready a member? Sign inActivella price by strength
| Strength | Lowest brand90 days | Price per tablet |
|---|---|---|
| Activella 0.5 mg/0.1 mg | $296.73 | $3.18 |
| Activella 1 mg/0.5 mg | $89.98 | $1.00 |
Lowest 90-day cost with shipping at licensed pharmacies shipping to the U.S. now, counting only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price per tablet is for that lowest pack, before shipping. Prices checked Nov 11, 2026.
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90-day prices from 9 licensed pharmacies abroad shipping to the U.S.: $89.98 to $557.09, any strength, shipping included.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Activella · Similar drugs · Uses · FAQ
Activella (estradiol and norethindrone acetate) is a once-a-day menopause hormone tablet for women with a uterus. FDA-approved generics are sold in the U.S.
Activella cost at a glance
- Generic Activella is sold in the U.S. The FDA has approved generic estradiol and norethindrone acetate tablets from several companies, rated equivalent to Activella (FDA Orange Book). U.S. list prices for 28 tablets of 1/0.5 mg include $40.90 (Ingenus) and $114.03 (Breckenridge), and Xiromed lists three packs of 28 at $44.11 (Texas DSHS).
- U.S. list price: $280.95 for a 28-tablet pack of brand Activella 1/0.5 mg (the maker's wholesale price before discounts). That is about $301.02 for 30 days or $903.05 for 90 days (Texas DSHS).
- How we count: 1 tablet a day. The label's dose is one tablet once a day, every day, so 90 days is 90 tablets (just over three 28-tablet packs).
- From online pharmacies abroad: $89.98 to $538.33 for 90 days of brand Activella 1/0.5 mg, shipping included (checked Nov 11, 2026). The U.S. list price for 90 days is about $903.05.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Activella cost in the U.S.?
| If you have | What Activella costs | Source |
|---|---|---|
| No insurance (list price) | $280.95 for 28 tablets of brand Activella 1/0.5 mg, about $10.03 a tablet (about $903.05 for 90 days). Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| No insurance (generic estradiol/norethindrone acetate) | FDA-approved generics are sold in the U.S. List prices for 28 tablets of 1/0.5 mg include $40.90 (Ingenus) and $114.03 (Breckenridge); for 0.5/0.1 mg, $45.25 (Ingenus) and $103.74 (Breckenridge). Ask your pharmacist for the cash price. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan's drug list. Ask your plan or pharmacist what you'd pay for brand Activella and for the generic. | FDA Orange Book |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Activella 1/0.5 mg lists at $280.95 for a 28-tablet pack, about $10.03 a tablet (Texas DSHS). This is the maker's wholesale price before discounts. FDA-approved generics have been sold in the U.S. since 2008, and Ingenus lists 28 tablets of 1/0.5 mg at $40.90 in the same filing. Brand Activella 0.5/0.1 mg has no list price there, and Drugs@FDA lists it as discontinued.
Activella cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for brand Activella or generic estradiol/norethindrone acetate depends on your plan's drug list.
| Medicare Part D | What Activella costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Activella coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Activella coupons. These programs can help with the cost of brand Activella or its generic:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Activella?
Yes. The FDA has approved generic estradiol and norethindrone acetate tablets in 1/0.5 mg and 0.5/0.1 mg from several companies, including Breckenridge, Xiromed, Novast (Ingenus) and Naari, rated equivalent to Activella. Breckenridge's 1/0.5 mg generic has been listed as on the U.S. market since April 17, 2008.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 1/0.5 mg | Yes | Breckenridge, Teva (Mimvey), Xiromed, Novast (Ingenus), Naari | Apr 17, 2008 |
| 0.5/0.1 mg | Yes | Breckenridge, Xiromed, Novast (Ingenus) | Jun 9, 2011 |
Outside the U.S.: Online pharmacies abroad may also sell generic estradiol and norethindrone acetate made for other markets. Those packs are not FDA-approved, and the price table labels them that way.
Source: FDA Orange Book: estradiol and norethindrone acetate tablets. As of Nov 11, 2026.
Compare Activella with similar drugs
Other menopause hormone medicines people often compare with Activella, such as Prempro, Angeliq and Bijuva (other estrogen-plus-progestin products) and Estrace (estrogen alone). Your prescriber decides which medicine is right for you. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Premproconjugated estrogens and medroxyprogesterone | Menopause hormone therapy (estrogen plus progestin) | $133.88 for 90 days | See prices |
| Angeliqdrospirenone and estradiol | Menopause hormone therapy (estrogen plus progestin) | Checking prices | See prices |
| Bijuvaestradiol and progesterone | Menopause hormone therapy (estrogen plus progesterone) | $123.16 for 90 days | See prices |
| Estraceestradiol | Estrogen hormone (menopause hormone therapy) | From $0.35 per tablet | See prices |
Lowest price from licensed pharmacies shipping to the U.S., any strength: 90-day prices include shipping; prices per unit are before shipping. Only your doctor can decide whether another drug is right for you.
What is Activella used for?
Activella combines an estrogen (estradiol) with a progestin (norethindrone acetate). The progestin is there to protect the lining of the uterus. According to its FDA label (DailyMed), it is used in women who have a uterus:
- To treat moderate to severe hot flashes and night sweats from menopause.
- To treat moderate to severe vaginal dryness and irritation from menopause (1/0.5 mg only; the label says vaginal products should be considered first when that's the only symptom).
- To help prevent osteoporosis after menopause (the label says non-estrogen medicines should be considered first).
Activella is one tablet taken once a day, every day, from a 28-tablet blister pack. The label says to use the lowest dose that works for the shortest time needed. The label says it must not be used by women with breast cancer, blood clots, stroke or heart attack, liver disease or unexplained vaginal bleeding. Boxed warning: the label carries the FDA's strongest warning. In the Women's Health Initiative study, estrogen plus progestin raised the risk of blood clots, stroke, heart attack and invasive breast cancer, and in women 65 and older the risk of probable dementia. Your prescriber decides which medicine is right for you.
Is it safe to order Activella from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Activella, compare the U.S. price of FDA-approved generics before you order. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Novo Nordisk sells the same combination as Activelle (1/0.5 mg) and Activelle LD (0.5/0.1 mg) (Health Canada).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Activella without insurance?
The U.S. list price of brand Activella 1/0.5 mg is $280.95 for 28 tablets, about $903.05 for 90 days (the maker's wholesale price before discounts). Licensed pharmacies abroad charged from $89.98 for 90 days in our latest check (Nov 11, 2026). FDA-approved generics are also sold in the U.S.; ask your pharmacist for the cash price.
Is there a generic Activella?
Yes. The FDA has approved generic estradiol and norethindrone acetate tablets in both strengths from several companies, rated equivalent to Activella. Some are sold under their own names, such as Mimvey and Abigale. Ask your pharmacist whether a generic can fill your prescription.
Is Activella more expensive than the generic?
At list prices, yes. A 28-tablet pack of brand Activella 1/0.5 mg lists at $280.95, while Ingenus's generic lists at $40.90 for 28 tablets. These are list prices; ask your pharmacist what you would pay. Your prescriber decides which medicine is right for you.
Is Activelle the same as Activella?
Activelle is the name Novo Nordisk uses outside the U.S., including in Canada, for the same combination of estradiol 1 mg and norethindrone acetate 0.5 mg. Activelle LD is the 0.5/0.1 mg strength. In the U.S., Amneal sells it as Activella.
Is there an Activella coupon or savings card?
eDrugSearch doesn't offer coupons of its own. Generics are sold in the U.S.; ask your pharmacist for the cash price. If you have Medicare and limited income, Extra Help can lower what you pay for prescriptions.
How much does Activella cost with Medicare?
It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. Ask your plan how it covers brand Activella and its generics. People with limited income can apply for Extra Help.
What strengths does Activella come in?
Activella comes as 1 mg estradiol with 0.5 mg norethindrone acetate, and a lower 0.5/0.1 mg strength, each in packs of 28 tablets. Drugs@FDA lists brand Activella 0.5/0.1 mg as discontinued, but generic 0.5/0.1 mg tablets are sold.
Sources
- Texas DSHS: 2026 annual WAC report (Activella 1/0.5 mg, 28 tablets (NDC 60846023201), $280.95; generic list prices (Ingenus, Breckenridge, Xiromed))
- ACTIVELLA U.S. prescribing information (DailyMed) (Amneal Pharmaceuticals, label version 18, effective November 30, 2023)
- Drugs@FDA: Activella (NDA 020907) (Amneal; 1/0.5 mg Prescription, TE code AB; 0.5/0.1 mg Discontinued (Federal Register: not for safety or effectiveness reasons))
- FDA Orange Book: estradiol and norethindrone acetate tablets
- FDA NDC Directory: Breckenridge estradiol/norethindrone acetate (NDC 51991-474) (ANDA 078324, marketing start April 17, 2008; 0.5/0.1 mg (51991-623) since June 9, 2011)
- Health Canada Drug Product Database: Activelle (Novo Nordisk Canada; Activelle 1/0.5 mg (DIN 02249405) and Activelle LD 0.5/0.1 mg (DIN 02309009) Marketed)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- FDA: personal importation
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