Prempro Cost, Coupons and Savings

Prempro cost with Medicare in 2026

In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for Prempro depends on your plan's drug list. The Pfizer co-pay card and the TrumpRx.gov coupon can't be used with Medicare.

Prempro coupons and savings programs

eDrugSearch does not offer its own Prempro coupons. These are the programs we could verify on Pfizer's and the government's own sites:

• TrumpRx.gov coupon: brand Prempro from $98.84 for 28 tablets (original price $254.30), with a coupon you show at a retail pharmacy that dispenses Prempro. Not for use with Medicare or Medicaid coverage; a cash purchase won't count toward your Medicare or Medicaid plan or the $2,100 Medicare out-of-pocket cap. With private insurance, ask your plan whether a cash purchase counts toward your deductible. (TrumpRx.gov)
• Pfizer MHT co-pay savings card: for people with private (commercial) insurance, age 18 or older. You may pay as little as $25 per prescription, with up to $110 off each Prempro fill and up to $1,440 a year. Not for Medicare, Medicaid, TRICARE, VA or other government programs, and not for cash-paying patients. Offer expires December 31, 2026. Call 1-888-966-4584 (1-888-WMN-HLTH). (Pfizer menopause savings)
• Pfizer Patient Assistance Program: Pfizer RxPathways lists Prempro among the medicines provided through the Pfizer Patient Assistance Program. You must be uninsured or have government insurance and be unable to afford your copay, live in the U.S., and meet household income limits, which vary by product. People with commercial insurance can't apply. Call 1-844-989-7284. (Pfizer RxPathways)
• Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
• Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)

Compare Prempro with similar drugs

Other menopause medicines people often compare with Prempro. Premarin is conjugated estrogens alone, Estring is a vaginal estrogen ring, and Osphena and Veozah are non-estrogen tablets. Prices are for each drug's lowest-priced strength.

Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.

What is Prempro used for?

Prempro combines conjugated estrogens with medroxyprogesterone, a progestin, in one daily tablet. According to its FDA label (DailyMed), it is used in women who have a uterus for:

• Moderate to severe hot flashes and night sweats (vasomotor symptoms) due to menopause.
• Moderate to severe vaginal dryness and irritation (vulvar and vaginal atrophy) due to menopause.
• Prevention of bone loss (osteoporosis) after menopause.

Prempro comes in four strengths, written as conjugated estrogens/medroxyprogesterone: 0.3/1.5, 0.45/1.5, 0.625/2.5 and 0.625/5 mg. One tablet is taken once a day. Boxed warning: the Prempro label on DailyMed (effective April 2026) carries the FDA's strongest warning. It says estrogen plus progestin should not be used to prevent heart disease or dementia. In the Women's Health Initiative study, estrogen plus progestin was linked to higher risks of blood clots, stroke, heart attack and invasive breast cancer, and to a higher risk of probable dementia in women 65 and older. The label says to use the lowest effective dose for the shortest time that fits a woman's treatment goals. Talk with your prescriber about these risks. Your prescriber decides which medicine is right for you.

Frequently asked questions