Home › Drug Prices › Lysodren
Lysodren Cost and Savings
- U.S. list price
- $19.46 per tabletThe maker's price for brand Lysodren before discounts · Source: Texas DSHS 2026 WAC report
- Lowest price per tablet at online pharmacies abroad
- $10.99 per tabletIn a pack of 100 tablets for $1,099 (before shipping) · brand Lysodren 500 mg, not FDA-approved · ships from United Kingdom
Sign in or get a free account, and we'll bring you back here. Free accounts: 2 alerts · Members: unlimited
Quick answerAs of Nov 11, 2026, brand Lysodren 500 mg costs from $10.99 per tablet abroad, before shipping, vs. about $19.46 a tablet at the U.S. list price ($1,945.62 per 100). No generic mitotane is sold in the U.S.
Compare Lysodren prices from licensed online pharmacies
For comparison U.S. pharmacy list price: $19.46 per tablet, brand Lysodren before insurance. The prices below are from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Pack | Price per unit | Pack price | Shipping & delivery | Total with shipping | Buy |
|---|---|---|---|---|---|---|---|
| Lowest price per unitOnline pharmacy A | Lysodren500 mg · brand · Filled in United KingdomMaker listed by pharmacy: HRA Pharma | 100 tablets | $10.99 per tablet | $1,099 | $9.95Pharmacy's estimate: 4–6 weeks | $1,108.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy B | Lysodren500 mg · brand · Filled in CanadaMaker listed by pharmacy: Bristol-Myers Squibb | 100 tablets | $11.97 per tablet | $1,197.21 | $14.95Pharmacy's estimate: 4–6 weeks | $1,212.16Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy C | Lysodren (Mitotane)500 mg · brand · Filled in CanadaMaker listed by pharmacy: Bristol-Myers Squibb | 300 tablets2 other pack sizes
| $12.23 per tablet | $3,668.19 | FreePharmacy's estimate: 2–3 weeks | $3,668.19Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed Canadian pharmacy D | Lysodren500 mg · brand · Filled in CanadaMaker listed by pharmacy: ESTEVE PHARMACEUTICALS S.A. | 300 tablets2 other pack sizes
| $12.79 per tablet | $3,835.57 | $9.95Pharmacy's estimate: 3–6 weeks | $3,845.52Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy A | Lysodren500 mg · brand · Filled in CanadaMaker listed by pharmacy: Bristol-Myers Squibb | 100 tablets | $12.86 per tablet | $1,286 | $9.95Pharmacy's estimate: 4–6 weeks | $1,295.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy C | Lysodren (Mitotane)500 mg · brand · Filled in United KingdomMaker listed by pharmacy: HRA Pharma | 100 tablets | $12.95 per tablet | $1,294.53 | FreePharmacy's estimate: 2–3 weeks | $1,294.53Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy EU.S. shipping limited | Lysodren (Mitotane)500 mg · brand · Filled in United KingdomProduct of United Kingdom | 100 tablets | $10.04 per tablet | $1,004 | $14.95Pharmacy's estimate: 8–14 business days | $1,018.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Lysodren from Canada?
Each row is one product from one pharmacy, shown in the pack size with the lowest price per unit; its other pack sizes are listed under “other pack sizes”. Price per unit = the pack price divided by the units in the pack, before shipping; we sort by it and don't assume how long a pack lasts. Total with shipping = the pack price plus the pharmacy's shipping fee for one order. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars (converted when a pharmacy prices in Canadian dollars). The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Prices change often; confirm at checkout.
Members see pharmacy names, ratings, visit links and price-drop alerts.
Join to See PharmaciesAlready a member? Sign inGet an email if the price drops. Free accounts can watch 2 medications. Sign in to watch this price
Prices per tablet from 4 licensed pharmacies shipping to the U.S.: $10.99 to $12.95, any strength, before shipping.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Lysodren · Similar drugs · Uses · FAQ
Lysodren (mitotane) 500 mg tablets treat adrenal gland cancer (adrenocortical carcinoma) that can't be removed by surgery. No U.S. generic is sold.
Lysodren cost at a glance
- U.S. list price: $1,945.62 for a bottle of 100 tablets of brand Lysodren 500 mg (the maker's wholesale price before discounts), about $19.46 a tablet. The maker reported a 15% price increase in the last calendar year and 40% over the last three (Texas DSHS).
- No generic in the U.S. The FDA has approved no generic mitotane. Lysodren is the only mitotane product in the FDA Orange Book (FDA Orange Book).
- How we count: prices are per tablet, with each pharmacy's packs listed as sold. The dose is set for each person: the label starts at 2,000 to 6,000 mg a day (4 to 12 tablets) in 3 or 4 doses, then adjusts it using blood levels.
- From online pharmacies abroad: $10.99 to $12.95 per tablet for brand Lysodren 500 mg, before shipping (checked Nov 11, 2026). The U.S. list price is about $19.46 a tablet.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Lysodren cost in the U.S.?
| If you have | What Lysodren costs | Source |
|---|---|---|
| No insurance (list price) | $1,945.62 for 100 tablets of brand Lysodren 500 mg, about $19.46 a tablet. Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan's drug list. In the U.S., Lysodren is filled through Walgreens Specialty Pharmacy, which can check your coverage and out-of-pocket cost. | Lysodren.com |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Lysodren 500 mg has a U.S. list price of $1,945.62 for 100 tablets, about $19.46 a tablet (Texas DSHS). This is the maker's wholesale price before discounts. No generic mitotane is sold in the U.S. The maker's website says Walgreens Specialty Pharmacy fills U.S. prescriptions and that financial help may be available; call 1-844-597-6373 to see if you qualify (Lysodren.com).
Lysodren cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for Lysodren depends on your plan's drug list.
| Medicare Part D | What Lysodren costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Lysodren coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
eDrugSearch does not offer its own Lysodren coupons. These programs can help with the cost of Lysodren:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Lysodren?
No. The FDA has not approved a generic version of Lysodren. Esteve's Lysodren 500 mg tablet is the only mitotane product in the FDA Orange Book, and FDA drug listings show no other mitotane tablets on the U.S. market.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 500 mg | No | — |
Outside the U.S.: Online pharmacies abroad may sell mitotane made for other markets. Those packs are not FDA-approved, and the price table labels them that way.
Source: FDA Orange Book: mitotane products. As of Nov 11, 2026.
Compare Lysodren with similar drugs
Other oral cancer medicines on eDrugSearch. They treat different cancers and aren't substitutes for Lysodren; your prescriber decides which medicine is right for you. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Temodartemozolomide | Cancer medicine (alkylating drug) | From $5.44 per capsule | See prices |
| Gleostinelomustine | Cancer medicine (alkylating chemotherapy) | From $8.41 per capsule | See prices |
| Hydreahydroxyurea | Cancer medicine (antimetabolite) | From $0.38 per capsule | See prices |
Lowest price per unit, before shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Lysodren used for?
Lysodren (mitotane) is an adrenal cytotoxic agent: a medicine that damages cells of the adrenal glands. According to its FDA label (DailyMed), it is used:
- To treat adrenocortical carcinoma (ACC), a cancer of the adrenal glands, when it can't be removed by surgery. It's used whether or not the tumor makes extra hormones.
Lysodren comes as a 500 mg scored tablet taken with food in 3 or 4 doses a day. The label says to raise the dose step by step while checking mitotane blood levels, and reaching the target level usually takes 3 to 5 months. It's a hazardous drug, so caregivers should wear disposable gloves when handling the tablets. Boxed warning: the label carries the FDA's strongest warning. People taking Lysodren are at higher risk of adrenal crisis, which can be fatal, during shock, severe injury or infection. Your prescriber decides which medicine is right for you.
Is it safe to order Lysodren from Canada?
Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Esteve sells Lysodren 500 mg tablets under the same name (Health Canada).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Lysodren without insurance?
The U.S. list price of brand Lysodren 500 mg is $1,945.62 for 100 tablets, about $19.46 a tablet (the maker's wholesale price before discounts). Licensed pharmacies abroad charged from $10.99 per tablet in our latest check (Nov 11, 2026), before shipping. Doses differ from person to person, so your monthly cost depends on your prescription.
Is there a generic Lysodren?
No. The FDA has not approved a generic mitotane. Esteve's Lysodren is the only mitotane tablet sold in the U.S.
How much does one Lysodren tablet cost?
At the U.S. list price, each Lysodren 500 mg tablet costs about $19.46 ($1,945.62 for 100). The label's starting dose is 4 to 12 tablets a day, adjusted by blood tests, so your cost depends on your dose. Insurance can change what you pay.
Is there financial help for Lysodren?
eDrugSearch doesn't offer coupons of its own. The maker's website says financial assistance may be available and asks patients to call 1-844-LYSODREN (1-844-597-6373) to see if they qualify. If you have Medicare and limited income, Extra Help can lower what you pay for prescriptions.
Where can I fill a Lysodren prescription in the U.S.?
The maker's website says Walgreens Specialty Pharmacy is the pharmacy for Lysodren prescriptions in the U.S. It can check your coverage and costs; its number is 1-800-320-2112.
How much does Lysodren cost with Medicare?
It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. People with limited income can apply for Extra Help, and the Medicare Prescription Payment Plan can spread costs over the year.
Sources
- Texas DSHS: 2026 annual WAC report (Lysodren 500 mg, 100 tablets (NDC 76336008060), $1,945.62; price increase 15% last calendar year, 40% over three years)
- LYSODREN U.S. prescribing information (DailyMed) (Esteve Pharmaceuticals, label version 18, effective March 3, 2026)
- Drugs@FDA: Lysodren (NDA 016885) (Esteve; 500 mg tablet, Prescription; no therapeutic equivalents)
- FDA Orange Book: mitotane products
- FDA NDC Directory: mitotane (only Lysodren listed (NDC 68118-080 Esteve; 76336-080 HRA Pharma Rare Diseases), checked November 11, 2026)
- Lysodren.com: Support and Resources (Walgreens Specialty Pharmacy fills U.S. prescriptions (1-800-320-2112); financial assistance may be available (1-844-597-6373); checked 2026-11-11)
- Health Canada Drug Product Database: Lysodren (Esteve Pharmaceuticals; 500 mg (DIN 00463221) Marketed)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.