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Hydrea Cost, Coupons and Generic
- U.S. list price
- $1.50 per capsuleThe maker's price for brand Hydrea before discounts · Source: Texas DSHS 2026 WAC report
- Lowest price per capsule at online pharmacies abroad
- $0.68 per capsuleIn a pack of 300 capsules for $203.47 (before shipping) · brand Hydrea 500 mg, not FDA-approved · ships from Mauritius
FDA-approved generic hydroxyurea 500 mg from $0.38 per capsule at U.S. pharmacies
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Quick answerAs of Nov 11, 2026, brand Hydrea 500 mg costs from $0.68 per capsule abroad, before shipping, vs. about $1.50 a capsule at the U.S. list price ($150.02 per 100). FDA-approved generic hydroxyurea is sold in the U.S., with list prices from $37.93 for 100 capsules.
Name check: Droxia, also hydroxyurea, comes in 200, 300 and 400 mg capsules for sickle cell anemia. It's a separate product, so its prices aren't mixed in here.
Compare Hydrea prices from licensed online pharmacies
For comparison U.S. pharmacy list price: $1.50 per capsule, brand Hydrea before insurance. The prices below are from U.S. pharmacies that publish cash prices and from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Pack | Price per unit | Pack price | Shipping & delivery | Total with shipping | Buy |
|---|---|---|---|---|---|---|---|
| Lowest price per unitOnline pharmacy A | HydroxyureaNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Zydus Cadilla | 100 capsules | $0.38 per capsule | $37.75 | $9.95Pharmacy's estimate: 4–6 weeks | $47.70Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy B | Hydroxyurea (Hydrea)500 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 90 capsules1 other pack size
| $0.38 per capsule | $34 | $5Pharmacy's estimate: 7–10 business days | $39Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy C | Generic Equivalent to Hydrea 500mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Zydus Cadila | 90 capsules2 other pack sizes
| $0.39 per capsule | $34.68 | $14.95Pharmacy's estimate: 4–6 weeks | $49.63Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | Generic Equivalent To Hydrea 500mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Zydus Cadila | 90 capsules2 other pack sizes
| $0.39 per capsule | $34.68 | $14.95Pharmacy's estimate: 4–6 weeks | $49.63Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | Hydroxyurea (Hydroxycarbamide) (UK/EU pack, ships from United Kingdom)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in United KingdomProduct of UK/EU | 100 capsules | $0.45 per capsule | $45.17 | Fee not publishedDelivery time not stated | $45.17+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | Generic Hydrea 500mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in IndiaMade for sale in India.Product of India | 90 capsules2 other pack sizes
| $0.50 per capsule | $45.08 | Fee not publishedDelivery time not stated | $45.08+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | Hydrea500 mg · brand · Filled in AustraliaProduct of Australia | 100 capsules | $0.55 per capsule | $54.97 | Fee not publishedDelivery time not stated | $54.97+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy G | Hydroxyurea (Hydroxycarbamide) (UK/EU pack, ships from United Kingdom)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in United KingdomProduct of UK/EU | 100 capsules | $0.56 per capsule | $55.99 | Fee not publishedDelivery time not stated | $55.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy H | Hydroxyurea 500mg Capsules500 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 180 capsules4 other pack sizes
| $0.56 per capsule | $100.80 | $5Pharmacy's estimate: 2–8 business days | $105.80Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy G | Hydrea500 mg · brand · Filled in AustraliaProduct of Australia | 100 capsules | $0.64 per capsule | $63.99 | Fee not publishedDelivery time not stated | $63.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy I | Hydroxyurea (Hydroxycarbamide) (UK/EU pack, ships from United Kingdom)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in United KingdomProduct of UK/EU | 100 capsules | $0.68 per capsule | $67.58 | $9.95Delivery time not stated | $77.53Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy J | HYDREA (Turkey pack, ships from Mauritius)500 mg · brand · Filled in MauritiusProduct of Turkey | 300 capsules1 other pack size
| $0.68 per capsule | $203.47 | FreeDelivery time not stated | $203.47Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy K | Hydrea (Hydroxyurea)500 mg · brand · Filled in TurkeyMade for sale in Turkey.Maker listed by pharmacy: Bristol Myers Squibb | 100 capsules | $0.74 per capsule | $73.93 | FreePharmacy's estimate: 2–3 weeks | $73.93Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy A | Hydrea500 mg · brand · Filled in United KingdomMaker listed by pharmacy: Bristol-Myers Squibb | 100 capsules | $0.82 per capsule | $82 | $9.95Pharmacy's estimate: 4–6 weeks | $91.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy C | Generic Equivalent to Hydrea 500mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in United StatesProduct of United States | 100 capsules | $0.82 per capsule | $82.34 | $14.95Pharmacy's estimate: 4–6 weeks | $97.29Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy I | Hydrea500 mg · brand · Filled in AustraliaProduct of Australia | 100 capsules | $0.84 per capsule | $84.40 | $9.95Delivery time not stated | $94.35Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy J | HYDROXYUREANot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in IndiaMade for sale in India.Product of India | 30 capsules | $0.86 per capsule | $25.65 | FreeDelivery time not stated | $25.65Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | Brand Hydrea 500mg500 mg · brand · Filled in IndiaMade for sale in India.Product of India | 90 capsules2 other pack sizes
| $0.89 per capsule | $80.18 | Fee not publishedDelivery time not stated | $80.18+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy A | Hydrea (Turkey pack, ships from Singapore)500 mg · brand · Filled in SingaporeMaker listed by pharmacy: Bristol-Myers SquibbMade for Turkey | 100 capsules | $0.90 per capsule | $90 | $9.95Pharmacy's estimate: 4–6 weeks | $99.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | Generic Equivalent to Hydrea 500mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in United StatesProduct of United States | 100 capsules | $0.91 per capsule | $90.57 | $14.95Pharmacy's estimate: 4–6 weeks | $105.52Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy J | HYDREA500 mg · brand · Filled in IndiaMade for sale in India.Product of India | 30 capsules | $0.95 per capsule | $28.48 | FreeDelivery time not stated | $28.48Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy L | Generic Equivalent to Hydrea 500mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in United StatesProduct of United States | 100 capsules | $0.95 per capsule | $95.10 | $14.95Pharmacy's estimate: 4–6 weeks | $110.05Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | Hydroxyurea (Hydroxycarbamide)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in CanadaProduct of Canada | 100 capsules | $0.99 per capsule | $98.93 | Fee not publishedDelivery time not stated | $98.93+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy G | Hydroxyurea (Hydroxycarbamide)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in CanadaProduct of Canada | 100 capsules | $1.09 per capsule | $108.99 | Fee not publishedDelivery time not stated | $108.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy K | Hydrea (Hydroxyurea)500 mg · brand · Filled in New ZealandMaker listed by pharmacy: Bristol Myers Squibb | 100 capsules | $1.11 per capsule | $110.79 | FreePharmacy's estimate: 2–3 weeks | $110.79Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy A | HydroxyureaNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in CanadaMaker listed by pharmacy: Mylan | 100 capsules2 other pack sizes
| $1.28 per capsule | $128 | $9.95Pharmacy's estimate: 4–6 weeks | $137.95Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed Canadian pharmacy M | HydroxyureaNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in CanadaMaker listed by pharmacy: Apotex | 100 capsules | $1.66 per capsule | $166.45 | $9.95Pharmacy's estimate: 3–6 weeks | $176.40Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy K | Hydroxyurea (Hydroxyurea)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.500 mg · generic · Filled in CanadaMaker listed by pharmacy: Apotex Inc | 100 capsules | $1.80 per capsule | $179.79 | FreePharmacy's estimate: 2–3 weeks | $179.79Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Hydrea from Canada?
Each row is one product from one pharmacy, shown in the pack size with the lowest price per unit; its other pack sizes are listed under “other pack sizes”. Price per unit = the pack price divided by the units in the pack, before shipping; we sort by it and don't assume how long a pack lasts. Total with shipping = the pack price plus the pharmacy's shipping fee for one order. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars (converted when a pharmacy prices in Canadian dollars). The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, plus its standard shipping; no insurance or discount cards. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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Prices per capsule from 8 licensed pharmacies abroad shipping to the U.S.: $0.38 to $1.80, any strength, before shipping.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Hydrea · Similar drugs · Uses · FAQ
Hydrea (hydroxyurea) 500 mg capsules treat resistant chronic myeloid leukemia and some head and neck cancers. FDA-approved generics are sold in the U.S.
Hydrea cost at a glance
- Generic Hydrea is sold in the U.S. The FDA has approved generic hydroxyurea 500 mg capsules from several companies, rated equivalent to Hydrea (FDA Orange Book). U.S. list prices for 100 generic capsules include $37.93 (AvKare), $39.97 (Par, Somerset) and $56.00 (Teva) (Texas DSHS).
- U.S. list price: $150.02 for a bottle of 100 capsules of brand Hydrea 500 mg (the maker's wholesale price before discounts), about $1.50 a capsule (Texas DSHS).
- How we count: prices are per capsule, with each pharmacy's packs listed as sold. The label sets the Hydrea dose by body weight (it starts at 15 mg per kg once a day when kidney function is normal), so the number of capsules differs from person to person.
- From online pharmacies abroad: $0.68 to $1.11 per capsule for brand Hydrea 500 mg, before shipping (checked Nov 11, 2026). The U.S. list price is about $1.50 a capsule.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Hydrea cost in the U.S.?
| If you have | What Hydrea costs | Source |
|---|---|---|
| No insurance (list price) | $150.02 for 100 capsules of brand Hydrea 500 mg, about $1.50 a capsule. Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| No insurance (generic hydroxyurea) | FDA-approved generic hydroxyurea is sold in the U.S. List prices for 100 capsules of 500 mg include $37.93 (AvKare), $39.97 (Par, Somerset) and $56.00 (Teva). Ask your pharmacist for the cash price. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan's drug list. Ask your plan or pharmacist what you'd pay for brand Hydrea and for the generic. | FDA Orange Book |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Hydrea 500 mg has a U.S. list price of $150.02 for 100 capsules, about $1.50 a capsule (Texas DSHS). This is the maker's wholesale price before discounts. FDA-approved generic hydroxyurea has been sold in the U.S. since 1998, and its list prices in the same filing start at $37.93 for 100 capsules. What a pharmacy charges you can differ.
Hydrea cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for brand Hydrea or generic hydroxyurea depends on your plan's drug list.
| Medicare Part D | What Hydrea costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Hydrea coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
eDrugSearch does not offer its own Hydrea coupons. These programs can help with the cost of brand Hydrea or generic hydroxyurea:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Hydrea?
Yes. The FDA has approved generic hydroxyurea 500 mg capsules from several companies, including Teva (Barr), Par, Leading and Qilu, all rated equivalent to Hydrea. Teva's has been listed as on the U.S. market since October 19, 1998.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 500 mg | Yes | Teva (Barr), Par, Leading, Qilu (Somerset) | Oct 19, 1998 |
Outside the U.S.: Online pharmacies abroad may also sell generic hydroxyurea made for other markets. Those packs are not FDA-approved, and the price table labels them that way.
Source: FDA Orange Book: hydroxyurea products. As of Nov 11, 2026.
Compare Hydrea with similar drugs
Other medicines for chronic myeloid leukemia (CML) on eDrugSearch, such as Gleevec (imatinib) and Tasigna (nilotinib). They work in different ways, and your prescriber decides which medicine is right for you. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Gleevecimatinib | Cancer medicine (kinase inhibitor) | From $0.38 per tablet | See prices |
| Tasignanilotinib | Cancer medicine (kinase inhibitor) | From $4.50 per capsule | See prices |
Lowest price per unit, before shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Hydrea used for?
Hydrea (hydroxyurea) is an antimetabolite, a cancer medicine that slows the growth of cells. According to its FDA label (DailyMed), it is used:
- To treat chronic myeloid leukemia (CML) that hasn't responded to other treatment.
- With chemotherapy and radiation, to treat locally advanced squamous cell cancers of the head and neck (not the lip).
The label bases the Hydrea dose on body weight, usually starting at 15 mg per kg once a day, with half that dose for people with reduced kidney function. The label says to swallow the capsules whole, never opened, and that caregivers should wear disposable gloves when handling them. The label also calls for weekly blood counts and recommends folic acid. Hydrea has no boxed warning, but the label warns that it can seriously lower blood counts and may cause other cancers. Your prescriber decides which medicine is right for you.
Is it safe to order Hydrea from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Hydrea, compare the U.S. price of FDA-approved generic hydroxyurea before you order. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Hydrea 500 mg capsules are sold under the same name by Cheplapharm (Health Canada).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Hydrea without insurance?
The U.S. list price of brand Hydrea 500 mg is $150.02 for 100 capsules, about $1.50 a capsule (the maker's wholesale price before discounts). Licensed pharmacies abroad charged from $0.68 per capsule in our latest check (Nov 11, 2026), before shipping. FDA-approved generic hydroxyurea is also sold in the U.S.; ask your pharmacist for its cash price.
Is there a generic Hydrea?
Yes. The FDA has approved generic hydroxyurea 500 mg capsules from several companies, rated equivalent to Hydrea. Generics have been sold in the U.S. since 1998. Ask your pharmacist whether a generic can fill your prescription.
Is Hydrea more expensive than hydroxyurea?
At list prices, yes. A bottle of 100 brand Hydrea capsules lists at $150.02, while 100 generic hydroxyurea capsules list at $37.93 to $56.00, depending on the maker. These are list prices; ask your pharmacist what you would pay. Your prescriber decides which medicine is right for you.
Is Hydrea the same as Droxia?
No. Both contain hydroxyurea, but Droxia comes in 200, 300 and 400 mg capsules and is approved for sickle cell anemia, while Hydrea comes in 500 mg capsules for certain cancers. They're separate products with separate prices. Your prescriber decides which medicine is right for you.
Is there a Hydrea coupon or savings card?
eDrugSearch doesn't offer coupons of its own. FDA-approved generic hydroxyurea is sold in the U.S.; ask your pharmacist for its cash price. If you have Medicare and limited income, Extra Help can lower what you pay.
How much does Hydrea cost with Medicare?
It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. Ask your plan how it covers brand Hydrea and generic hydroxyurea.
Sources
- Texas DSHS: 2026 annual WAC report (Hydrea 500 mg, 100 capsules (NDC 61269083510), $150.02 (older NDC 00003083050 $136.51); generic hydroxyurea list prices (AvKare, Par, Somerset, Teva))
- HYDREA U.S. prescribing information (DailyMed) (H2-Pharma, label version 21, effective January 26, 2026)
- Drugs@FDA: Hydrea and Droxia (NDA 016295) (Waylis Therapeutics; Hydrea 500 mg Prescription, TE code AB; Droxia 200/300/400 mg separate; approved December 7, 1967)
- FDA Orange Book: hydroxyurea products
- Drugs@FDA: Teva (Barr) hydroxyurea (ANDA 075143) (approved October 16, 1998)
- FDA NDC Directory: Teva hydroxyurea 500 mg (NDC 0555-0882) (ANDA 075143, marketing start October 19, 1998)
- Health Canada Drug Product Database: Hydrea (Cheplapharm; 500 mg (DIN 00465283) Marketed)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.