Home › Drug Prices › Auvelity
Auvelity Price (dextromethorphan and bupropion)
Auvelity's U.S. list price is $3,744 for 90 days. In our latest check (Nov 5, 2026), none of the licensed pharmacies abroad we list sold brand Auvelity 45/105 mg with a named maker, so the U.S. options below are the ones we can confirm.
- U.S. list price
- $3,744 for 90 days (180 tablets)The maker's price for brand Auvelity before discounts · Source: Axsome Therapeutics
- Lowest international online pharmacy price
- Not available
Compare Auvelity prices from licensed pharmacies
In our latest check, we found no licensed online pharmacy abroad selling this medicine.
Jump to: Medicare · Maker savings · Generic Auvelity · Similar drugs · Uses · FAQ
Auvelity (dextromethorphan and bupropion) extended-release tablets, 45/105 mg and 30/105 mg. No U.S. generic; see list prices, savings card and Medicare costs.
Cheapest ways to get Auvelity 45/105 mg
The cheapest ways we found to get brand Auvelity 45/105 mg (prices checked Nov 5, 2026). The lowest 90-day cost is shaded green.
| Way to buy | Cost | Details |
|---|---|---|
| U.S. list price | $3,744 for 90 days | Brand Auvelity before insurance. Pharmacies may charge more. |
| Medicare Part D | Depends on your plan | Your plan’s drug list and coverage phase set your cost. Medicare costs |
Costs abroad and at U.S. pharmacies are for one order closest to 90 days, shipping included, from the price table above. Programs set their own rules, so check the terms before you count on one.
How much does Auvelity cost without insurance?
Without insurance, Auvelity costs $1,248 for a 30-day supply at the U.S. list price, or about $3,744 for 90 days. Maker programs: We found no Axsome cash price or free-medicine program for Auvelity in our latest check. Axsome's support site lists independent charities that may help with costs (Axsome Therapeutics).
Auvelity cost with Medicare
In 2026, a Medicare drug plan (Part D) can charge a deductible of up to $615, and once you've spent $2,100 out of pocket on covered drugs, you pay nothing more for covered drugs that year ($2,400 in 2027) (Medicare.gov). What you pay for Auvelity depends on your plan's drug list and your coverage phase. If your income is limited, Extra Help lowers drug costs: in 2026 you pay no more than $5.10 for a generic and $12.65 for a brand-name drug, with income under $23,940 ($32,460 for a married couple) and resources under $18,090 ($36,100 for a couple) (CMS). The free Medicare Prescription Payment Plan spreads costs into monthly payments, but it doesn't lower the total.
| Medicare Part D | What Auvelity costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026 ($2,400 in 2027), you pay nothing more for covered drugs that year. | Medicare.gov |
Auvelity cost with insurance
With private or employer insurance, what you pay for Auvelity depends on your plan's drug list, deductible and copay. As little as $10 for up to a 90-day prescription with the Auvelity OnMySide copay program. If your plan doesn't cover Auvelity yet, up to 2 fills (120 tablets total) for as little as $10 per fill (Axsome Therapeutics).
Medicaid: Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office (Medicaid.gov).
Auvelity patient assistance program
We haven't found a patient assistance program for Auvelity. In our checks of Axsome Therapeutics's own pages, we found no free-medicine program that lists Auvelity. If you have Medicare and a limited income, Medicare Extra Help can lower what you pay for covered drugs.
Is there a generic Auvelity?
No. There is no FDA-approved generic Auvelity. Under a 2025 patent settlement, Axsome says Teva may sell a generic version starting September 30, 2038, or March 31, 2039 if pediatric exclusivity is granted, subject to FDA approval.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 30/105 mg | No | — | |
| 45/105 mg | No | — |
Outside the U.S.: Online pharmacies abroad may list Auvelity. Any pack must be brand Auvelity by Axsome; separate bupropion or dextromethorphan products are not Auvelity.
Source: FDA Orange Book: Auvelity (NDA 215430). As of Oct 26, 2026.
Auvelity FAQ
How much does Auvelity cost without insurance?
The U.S. list price is $20.80 per tablet: $1,248 for 60 tablets of Auvelity 45/105 mg, a 30-day supply at one tablet twice a day, or about $3,744 for 90 days. In our October 2026 check, we found no licensed online pharmacy abroad selling brand Auvelity. We found no Axsome cash price for Auvelity.
How much does Auvelity cost with Medicare?
It depends on your Part D plan. In 2026, plans can have a deductible of up to $615, and out-of-pocket costs for covered drugs are capped at $2,100 a year ($2,400 in 2027). The Auvelity copay program can't be used with Medicare, but people with limited income can apply for Extra Help; Axsome says qualified patients may pay less than $13 a month.
Is there a generic Auvelity?
No. The FDA has not approved a generic Auvelity. Under a 2025 patent settlement, Axsome says Teva may sell a generic version starting September 30, 2038, or March 31, 2039 if pediatric exclusivity is granted, subject to FDA approval.
Is there a patient assistance program for Auvelity?
We haven't found a patient assistance program for Auvelity. In our checks of Axsome Therapeutics's own pages, we found no free-medicine program that lists Auvelity. If you have Medicare and a limited income, Medicare Extra Help can lower what you pay for covered drugs.
Is Auvelity the same as bupropion (Wellbutrin)?
No. Auvelity combines dextromethorphan and bupropion in fixed doses in one extended-release tablet, approved by the FDA as its own product. Bupropion-only medicines such as Wellbutrin XL and their generics are different products, and there is no FDA-approved generic equivalent of Auvelity. Your prescriber decides which medicine is right for you.
What strengths does Auvelity come in?
Auvelity comes as 45 mg/105 mg tablets (bottles of 30 and 60) and 30 mg/105 mg tablets. The 30/105 mg tablets come in a titration pack for agitation with Alzheimer's dementia. The label's maximum dose is one tablet twice a day, so a 30-day supply is usually 60 tablets.
Is Auvelity a controlled substance?
No. The FDA's drug listing for Auvelity shows no DEA schedule.
Savings programs from the maker
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Auvelity coupons. We found no Axsome cash price or free-medicine program for Auvelity in our latest check. Axsome's support site points to independent charities that may help with costs (Financial Support Finder). These are the programs we could verify:
- Auvelity OnMySide Savings Card: for people with commercial insurance (through a job or bought on your own). You may pay as little as $10 for up to a 90-day prescription; if your plan doesn't cover Auvelity yet, up to 2 fills (120 tablets total) for as little as $10 per fill while your doctor asks for coverage. Monthly, yearly or per-claim limits may apply. Not for Medicare, Medicaid, TRICARE or other government plans, and not for cash-paying patients. Enroll online or text SAVE to 61489; questions 1-800-805-8621. (savings card)
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. Axsome says qualified patients may pay less than $13 a month for Auvelity. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Compare Auvelity with similar drugs
Other prescription medicines for depression, including Rexulti, which is also approved for agitation with Alzheimer's dementia. Prices are for each drug's most common strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Trintellixvortioxetine | Antidepressant (serotonin modulator) | $82.55 for 90 days | See prices |
| Rexultibrexpiprazole | Mental health medicine (atypical antipsychotic) | $384.95 for 90 days | See prices |
| Caplytalumateperone | Mental health medicine (atypical antipsychotic) | Checking prices | See prices |
| Vraylarcariprazine | Mental health medicine (atypical antipsychotic) | $65.92 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Auvelity used for?
Auvelity combines dextromethorphan and bupropion in one extended-release tablet. According to its FDA label (DailyMed), it is used to treat:
- Major depressive disorder (MDD) in adults.
- Agitation associated with dementia due to Alzheimer's disease. The label says it is not for as-needed use.
Auvelity comes as 45/105 mg tablets in bottles of 30 and 60, and as 30/105 mg tablets, which come in a titration pack for Alzheimer's agitation together with 45/105 mg tablets. The label has a boxed warning: in short-term studies, antidepressants raised the risk of suicidal thoughts and behaviors in children, teens and young adults, and Auvelity is not approved for children. Your prescriber decides which medicine is right for you.
Is it safe to order Auvelity from Canada?
Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress declared in FD&C Act 804(j)(1), 21 U.S.C. 384(j)(1), that enforcement against individuals should focus on imports posing a significant threat to public health. You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027.
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Sources
- Axsome Therapeutics: Auvelity price disclosure (Colorado) (WAC $624 for 30 tablets ($1,248 for 60) of 45/105 mg, dated February 2026)
- Vermont Attorney General: Axsome new drug notice, Auvelity titration pack (WAC $1,060.80 for 51 tablets, introduced June 8, 2026)
- Auvelity OnMySide Savings Card (checked 2026-10-26)
- Auvelity savings card terms and conditions
- Auvelity: access, coverage and savings (checked 2026-10-26)
- AUVELITY prescribing information (DailyMed) (label effective August 2026)
- FDA: AUVELITY prescribing information (revised 4/2026)
- FDA Orange Book: Auvelity (NDA 215430) patents and exclusivity (EOBZIP_2026_09)
- Axsome: settlement with Teva on Auvelity patent litigation (SEC filing) (February 10, 2025)
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket cap in 2026; $2,400 in 2027)
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicaid.gov: cost sharing
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.