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Astagraf XL Cost, Generic and Savings

U.S. list price
$5.95 per capsuleThe maker's price for brand Astagraf XL before discounts · Source: Texas DSHS 2026 WAC report
Lowest price per capsule at online pharmacies abroad
$3.38 per capsuleIn a pack of 100 capsules for $338 (before shipping) · brand Astagraf XL 1 mg, not FDA-approved · ships from Canada
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Prices checked Nov 11, 2026 · Page updated November 12, 2026 · By the eDrugSearch team · How we check pharmacies and prices

Quick answerAs of Nov 11, 2026, brand Astagraf XL 1 mg costs from $3.38 per capsule abroad, before shipping, vs. about $5.95 a capsule at the U.S. list price ($178.51 per 30). An FDA-approved generic of Astagraf XL is also sold in the U.S.

Name check: Astagraf XL is a once-a-day capsule. It is not the same as twice-daily Prograf or Envarsus XR tablets, and the label says they aren't interchangeable.

Compare Astagraf XL prices from licensed online pharmacies

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For comparison U.S. pharmacy list price: $5.95 per capsule, brand Astagraf XL 1 mg before insurance. The prices below are from licensed online pharmacies outside the U.S.

PharmacyMedicationPackPrice per unitPack priceShipping & deliveryTotal with shippingBuy
Online pharmacy ABrand Advagraf ER 0.5mg (sold outside the U.S. as Advagraf, Astellas)0.5 mg · brand · Filled in TurkeyMade for sale in Turkey.Maker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $75.07 ($1.50 per capsule), $90.02 with shipping
$1.47 per capsule$147.14$14.95Pharmacy's estimate: 4–6 weeks$162.09Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy BBrand Advagraf ER 0.5mg (sold outside the U.S. as Advagraf, Astellas)0.5 mg · brand · Filled in TurkeyMade for sale in Turkey.Maker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $82.58 ($1.65 per capsule), $97.53 with shipping
$1.62 per capsule$161.85$14.95Pharmacy's estimate: 4–6 weeks$176.80Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy CAdvagraf PR (Tacrolimus) (sold outside the U.S. as Advagraf, Astellas)0.5 mg · brand · Filled in United KingdomMaker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $142.29 ($2.85 per capsule), $142.29 with shipping
$2.46 per capsule$246.25FreePharmacy's estimate: 2–3 weeks$246.25Checked Nov 11See pharmacy (members) Members see the pharmacy
Licensed Canadian pharmacy DAdvagraf ER (sold outside the U.S. as Advagraf, Astellas)0.5 mg · brand · Filled in CanadaMaker listed by pharmacy: Astellas Pharma Canada100 capsules
1 other pack size
  • 50 capsules: $165.35 ($3.31 per capsule), $175.30 with shipping
$2.99 per capsule$298.75$9.95Pharmacy's estimate: 3–6 weeks$308.70Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy CAdvagraf ER (Tacrolimus) (sold outside the U.S. as Advagraf, Astellas)0.5 mg · brand · Filled in CanadaMaker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $172.74 ($3.45 per capsule), $172.74 with shipping
$3.00 per capsule$299.80FreePharmacy's estimate: 2–3 weeks$299.80Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy EAstagraf XL (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in CanadaMaker listed by pharmacy: Astellas Pharma Ltd100 capsules
1 other pack size
  • 50 capsules: $179 ($3.58 per capsule), $188.95 with shipping
$3.38 per capsule$338$9.95Pharmacy's estimate: 4–6 weeks$347.95Checked Nov 11See pharmacy (members) Members see the pharmacy
Licensed Canadian pharmacy DTacrolimus XRNot FDA-approved1 mg · generic · Filled in CanadaMaker listed by pharmacy: Sandoz90 capsules
2 other pack sizes
  • 60 capsules: $230.50 ($3.84 per capsule), $240.45 with shipping
  • 30 capsules: $136 ($4.53 per capsule), $145.95 with shipping
$3.47 per capsule$312.40$9.95Pharmacy's estimate: 3–6 weeks$322.35Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy CAdvagraf ER (Tacrolimus) (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in CanadaMaker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $205.29 ($4.11 per capsule), $205.29 with shipping
$3.71 per capsule$371.20FreePharmacy's estimate: 2–3 weeks$371.20Checked Nov 11See pharmacy (members) Members see the pharmacy
Licensed Canadian pharmacy DAdvagraf ER (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in CanadaMaker listed by pharmacy: Astellas Pharma Canada100 capsules
1 other pack size
  • 50 capsules: $205.04 ($4.10 per capsule), $214.99 with shipping
$3.74 per capsule$373.72$9.95Pharmacy's estimate: 3–6 weeks$383.67Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy CTacrolimus XR (Tacrolimus)Not FDA-approved1 mg · generic · Filled in CanadaMaker listed by pharmacy: Sandoz USA90 capsules
2 other pack sizes
  • 60 capsules: $259.99 ($4.33 per capsule), $259.99 with shipping
  • 30 capsules: $149.99 ($5.00 per capsule), $149.99 with shipping
$3.76 per capsule$337.99FreePharmacy's estimate: 2–3 weeks$337.99Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy CAdvagraf PR (Tacrolimus) (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in United KingdomMaker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $226.29 ($4.53 per capsule), $226.29 with shipping
$4.15 per capsule$415.30FreePharmacy's estimate: 2–3 weeks$415.30Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy ABrand Advagraf ER 1mg (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in TurkeyMade for sale in Turkey.Maker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $222.55 ($4.45 per capsule), $237.50 with shipping
$4.36 per capsule$436.20$14.95Pharmacy's estimate: 4–6 weeks$451.15Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy FASTAGRAF XL (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in CanadaProduct of Canada100 capsules$4.37 per capsule$436.89FreeDelivery time not stated$436.89Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy GASTAGRAF XL (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in CanadaProduct of Canada100 capsules$4.39 per capsule$439.28FreeDelivery time not stated$439.28Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy BBrand Advagraf ER 1mg (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in TurkeyMade for sale in Turkey.Maker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $244.81 ($4.90 per capsule), $259.76 with shipping
$4.80 per capsule$479.82$14.95Pharmacy's estimate: 4–6 weeks$494.77Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy HASTAGRAF XL 1MG CAPSULE 100 (ADVAGRAF BRAND FROM CANADA) (sold outside the U.S. as Advagraf, Astellas)1 mg · brand · Filled in CanadaProduct of Canada100 capsules$5.19 per capsule$518.50$14.95Pharmacy's estimate: 4–6 weeks$533.45Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy BBrand Advagraf 5mg (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Astellas Pharma90 capsules
2 other pack sizes
  • 60 capsules: $419.74 ($7.00 per capsule), $434.69 with shipping
  • 30 capsules: $251.84 ($8.39 per capsule), $266.79 with shipping
$5.83 per capsule$524.67$14.95Pharmacy's estimate: 4–6 weeks$539.62Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy ABrand Advagraf ER 5mg (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in TurkeyMade for sale in Turkey.Maker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $667.85 ($13.36 per capsule), $682.80 with shipping
$13.09 per capsule$1,308.99$14.95Pharmacy's estimate: 4–6 weeks$1,323.94Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy CTacrolimus XR (Tacrolimus)Not FDA-approved5 mg · generic · Filled in CanadaMaker listed by pharmacy: Sandoz USA90 capsules
2 other pack sizes
  • 60 capsules: $869.99 ($14.50 per capsule), $869.99 with shipping
  • 30 capsules: $459.99 ($15.33 per capsule), $459.99 with shipping
$14.09 per capsule$1,267.99FreePharmacy's estimate: 2–3 weeks$1,267.99Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy BBrand Advagraf ER 5mg (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in TurkeyMade for sale in Turkey.Maker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $734.64 ($14.69 per capsule), $749.59 with shipping
$14.40 per capsule$1,439.89$14.95Pharmacy's estimate: 4–6 weeks$1,454.84Checked Nov 11See pharmacy (members) Members see the pharmacy
Licensed Canadian pharmacy DTacrolimus XRNot FDA-approved5 mg · generic · Filled in CanadaMaker listed by pharmacy: Sandoz90 capsules
2 other pack sizes
  • 60 capsules: $892 ($14.87 per capsule), $901.95 with shipping
  • 30 capsules: $461.50 ($15.38 per capsule), $471.45 with shipping
$14.46 per capsule$1,301.50$9.95Pharmacy's estimate: 3–6 weeks$1,311.45Checked Nov 11See pharmacy (members) Members see the pharmacy
Licensed Canadian pharmacy DAdvagraf ER (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in CanadaMaker listed by pharmacy: Astellas Pharma Canada100 capsules
1 other pack size
  • 50 capsules: $772.83 ($15.46 per capsule), $782.78 with shipping
$15.23 per capsule$1,522.53$9.95Pharmacy's estimate: 3–6 weeks$1,532.48Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy CAdvagraf PR (Tacrolimus) (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in United KingdomMaker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $823.36 ($16.47 per capsule), $823.36 with shipping
$15.67 per capsule$1,567.43FreePharmacy's estimate: 2–3 weeks$1,567.43Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy HASTAGRAF XL 5MG CAPSULE 100 (ADVAGRAF BRAND FROM CANADA) (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in CanadaProduct of Canada100 capsules$16.75 per capsule$1,675$14.95Pharmacy's estimate: 4–6 weeks$1,689.95Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy CAdvagraf ER (Tacrolimus) (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in CanadaMaker listed by pharmacy: Astellas Pharma100 capsules
1 other pack size
  • 50 capsules: $856.29 ($17.13 per capsule), $856.29 with shipping
$16.75 per capsule$1,675.30FreePharmacy's estimate: 2–3 weeks$1,675.30Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy FASTAGRAF XL (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in CanadaProduct of Canada100 capsules$20.16 per capsule$2,015.64FreeDelivery time not stated$2,015.64Checked Nov 11See pharmacy (members) Members see the pharmacy
Online pharmacy GASTAGRAF XL (sold outside the U.S. as Advagraf, Astellas)5 mg · brand · Filled in CanadaProduct of Canada100 capsules$20.18 per capsule$2,018.03FreeDelivery time not stated$2,018.03Checked Nov 11See pharmacy (members) Members see the pharmacy

Buying from a pharmacy outside the U.S.? Read Is it safe to order Astagraf XL from Canada?

StrengthLowest brandper unit, before shippingLowest generic abroadper unit, not FDA-approved
Astagraf XL 0.5 mg$1.47 per capsule—
Astagraf XL 1 mg$3.38 per capsule$3.47 per capsule
Astagraf XL 5 mg$5.83 per capsule$14.09 per capsule

Each row is one product from one pharmacy, shown in the pack size with the lowest price per unit; its other pack sizes are listed under “other pack sizes”. Price per unit = the pack price divided by the units in the pack, before shipping; we sort by it and don't assume how long a pack lasts. Total with shipping = the pack price plus the pharmacy's shipping fee for one order. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars (converted when a pharmacy prices in Canadian dollars). The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Prices change often; confirm at checkout.

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Prices per capsule from 8 licensed pharmacies shipping to the U.S.: $1.47 to $20.18, any strength, before shipping.

Jump to: U.S. cost · Medicare · Coupons & savings · Generic Astagraf XL · Similar drugs · Uses · FAQ

Astagraf XL (once-daily tacrolimus) helps prevent kidney transplant rejection, in 0.5, 1 and 5 mg capsules. An FDA-approved generic is sold in the U.S.

Astagraf XL cost at a glance

  • U.S. list price: a bottle of 30 Astagraf XL capsules lists at $89.25 for 0.5 mg, $178.51 for 1 mg and $892.54 for 5 mg (the maker's wholesale price before discounts), about $2.98, $5.95 and $29.75 a capsule (Texas DSHS).
  • Generic Astagraf XL 1 mg is sold in the U.S. The FDA approved Chengdu Suncadia's generic tacrolimus extended-release capsules (0.5, 1 and 5 mg) on January 25, 2024, rated equivalent to Astagraf XL; the FDA's drug listing shows the 1 mg capsule on the market (Drugs@FDA).
  • How we compare: the label sets each person's dose by body weight and blood tests, so the number of capsules a day varies. We list each pharmacy's packs as sold and compare the price per capsule.
  • With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
  • From online pharmacies abroad: $3.38 to $5.19 per capsule of brand Astagraf XL 1 mg, before shipping (checked Nov 11, 2026). The U.S. list price is about $5.95 a capsule.

How much does Astagraf XL cost in the U.S.?

If you haveWhat Astagraf XL costsSource
No insurance (list price)Brand Astagraf XL, 30 capsules: $89.25 (0.5 mg), $178.51 (1 mg) or $892.54 (5 mg). Pharmacies may charge more.Texas DSHS 2026 WAC report
No insurance (generic)An FDA-approved generic of Astagraf XL (Chengdu Suncadia) is sold in the U.S. Ask your pharmacist for the cash price.Drugs@FDA
Private or employer insuranceYour copay depends on your plan's drug list and whether it covers brand Astagraf XL or the generic.Drugs@FDA
Medicare Part DYour cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100.Medicare.gov
MedicaidYour state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office.Medicaid.gov

Brand Astagraf XL 1 mg lists at $178.51 for 30 capsules, about $5.95 a capsule (Texas DSHS). How many capsules you need depends on your dose, which your transplant team adjusts with blood tests. List prices are what makers charge wholesalers; what a pharmacy charges you can differ.

Astagraf XL cost with Medicare in 2026

In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for Astagraf XL or its generic depends on your plan's drug list.

Medicare Part DWhat Astagraf XL costsSource
Part D deductibleNo Medicare drug plan may have a deductible above $615 in 2026. Some plans have none.Medicare.gov
Yearly out-of-pocket capOnce your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year.Medicare.gov

Astagraf XL coupons and savings programs

How do you pay?

We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.

eDrugSearch does not offer its own Astagraf XL coupons. eDrugSearch has no coupons of its own. If you have Medicare, these two programs can help with the cost of Astagraf XL or its generic:

  • Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
  • Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)

Is there a generic Astagraf XL?

Yes, for 1 mg. The FDA approved Chengdu Suncadia's generic tacrolimus extended-release capsules (0.5, 1 and 5 mg) on January 25, 2024, rated equivalent to Astagraf XL. The FDA's drug listing shows the 1 mg capsule on the market since that date.

StrengthU.S. genericMakersSince
0.5 mgNo—
1 mgYesChengdu SuncadiaJan 25, 2024
5 mgNo—

Outside the U.S.: Online pharmacies abroad may also sell once-daily tacrolimus made for other markets. Those packs are not FDA-approved, and the price table labels them that way.

Source: Drugs@FDA: tacrolimus extended-release capsules (ANDA 215012). As of Nov 11, 2026.

Compare Astagraf XL with similar drugs

Other anti-rejection medicines. They aren't interchangeable, and your transplant team decides which medicine is right for you. Prices are for each drug's lowest-priced strength.

DrugTypeLowest price we foundLink
PrograftacrolimusTransplant medicine (immunosuppressant)From $0.72 per capsuleSee prices
Envarsus XRtacrolimus extended-releaseTransplant medicine (immunosuppressant)From $2.92 per tabletSee prices
RapamunesirolimusTransplant medicine (immunosuppressant)From $2.59 per tabletSee prices
ImuranazathioprineImmunosuppressantFrom $0.30 per tabletSee prices

Lowest price per unit, before shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.

What is Astagraf XL used for?

Astagraf XL (tacrolimus) is an immunosuppressant. It lowers the immune system's attack on a new organ. According to its FDA label (DailyMed), it is used:

  • With other anti-rejection medicines, to help prevent organ rejection in adults and children with a kidney transplant who can swallow capsules whole.

Astagraf XL is taken once a day, every morning, on an empty stomach, and swallowed whole. The dose is set by body weight and adjusted with regular blood tests of tacrolimus levels. Boxed warning: the label carries the FDA's strongest warning. Like other immunosuppressants, Astagraf XL raises the risk of serious infections and cancers, and it showed higher death rates in women after liver transplant, so it isn't approved for liver transplants. Your prescriber decides which medicine is right for you.

Is it safe to order Astagraf XL from Canada?

Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Astellas sells once-daily tacrolimus capsules as Advagraf, in 0.5, 1, 3 and 5 mg (Health Canada). The 3 mg strength isn't sold in the U.S.

Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.

Frequently asked questions

How much is Astagraf XL without insurance?

The U.S. list price of Astagraf XL is $89.25 (0.5 mg), $178.51 (1 mg) or $892.54 (5 mg) for 30 capsules, in the Texas 2026 drug price filing. Licensed pharmacies abroad charged from $3.38 per capsule of Astagraf XL 1 mg in our latest check (Nov 11, 2026), before shipping.

Is there a generic for Astagraf XL?

Yes. The FDA approved Chengdu Suncadia's generic tacrolimus extended-release capsules on January 25, 2024, rated equivalent to Astagraf XL. The FDA's drug listing shows the 1 mg capsule on the market. Ask your transplant team and pharmacist about it.

Is there an Astagraf XL coupon or savings card?

eDrugSearch doesn't offer coupons of its own. If you have Medicare and limited income, Extra Help can lower what you pay, and the Medicare Prescription Payment Plan can spread costs over the year.

How much does Astagraf XL cost with Medicare?

It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. People with limited income can apply for Extra Help.

Is Astagraf XL the same as Advagraf?

Both are Astellas's once-daily tacrolimus capsules. Astagraf XL is the U.S. name, and Advagraf is the name in Canada and many other countries. The price table shows each pack's name and country.

Is Astagraf XL the same as Prograf?

No. Both contain tacrolimus, but Prograf is taken twice a day and Astagraf XL once a day. The label says Astagraf XL isn't interchangeable or substitutable for immediate-release tacrolimus capsules like Prograf.

Does Astagraf XL have a boxed warning?

Yes. The label warns of a higher risk of serious infections and cancers, as with other immunosuppressants, and of higher death rates in women after liver transplant. It isn't approved for liver transplants.

Sources

eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.