Additional Ways to Reduce Your Aciphex Costs

Lower Price Alternative

There may be other drugs in the same class (that function similarly) that can help you with your illness at a lower cost.

If you're on a pricey brand-name-only medication, it's worth asking your doctor if there are any less expensive, generic, or over-the-counter alternatives that could work for you.

Keep in mind, brand-name drugs found on eDrugSearch are often cheaper than their generic counterpart because they come from licensed Canadian pharmacies where they control high drug prices. Remember, the Canadian government, which covers the cost of prescription medicines, will not pay for medicine if their Patented Medicine Prices Review Board, determines that the drug price is excessive.

Fill a 90-Day Supply for More Savings

If you fill a 90-day prescription, you may discover that your total cost for the medicine is lower. As an additional benefit, you will have even more time to reorder your medications online, thus saving you more money and time.

A Non-Prescription Version Is Available

The manufacturer offers a similar, over-the-counter (OTC) version that is a less expensive product that may be purchased without a prescription.

If you're paying out of pocket (you don't have insurance or your insurance doesn't cover this drug), it may be a less expensive alternative. If you have insurance that covers the prescription version, your co-pay may yet be less.

It's worth noting that certain dosages and forms may only be obtained with a prescription.

Aciphex (rabeprazole) is a proton pump inhibitor (PPI) that is a reliable choice for decreasing stomach acid and is also used to treat ulcers, heartburn, and other stomach acid-related conditions like Zollinger-Ellison syndrome.

Common Brand Name

Aciphex and Aciphex Sprinkle

Drug Class

Proton pump inhibitors (PPIs)

Controlled Substance Classification

Non-controlled medication

Generic Status

The generic version is available


Prescription-only medication

Last Reviewed On:

January 17th, 2022

What is Aciphex?

How Does Aciphex work?

Aciphex (rabeprazole) is a PPI (proton pump inhibitor) that constrains the production of stomach acid in the stomach, making it less acidic. It's used to treat various disorders caused by excessive stomach acidity.

What is Aciphex used for?

  • It is used to treat gastroesophageal reflux disease (GERD) and acid reflux
  • Treatment of duodenal ulcers which are the first portion of the small intestine
  • The prevention of duodenal ulcers caused by H. pylori infection
  • To treat other uncommon health conditions that cause excessive stomach acid production, such as Zollinger-Ellison syndrome

Dosage forms


Typical dosages

  • GERD (gastroesophageal reflux disease) and duodenal ulcers - The usual dosage is 20 mg per day, taken by mouth once a day.
  • Ulcer prevention caused by H. Pylori infection - The typical daily dosage is 20 milligrams by mouth twice a day, taken with all meals (morning and evening). Rabeprazole (Aciphex) should be taken along with the antibiotics you'll need to complete the prescription.
  • For excess stomach acid, for example, Zollinger-Ellison syndrome - The initial dose is usually 60 mg by mouth once a day.

Safely Compare Aciphex Prices Online

Use the tips below to compare Aciphex prices online, so you can access the best Aciphex retail price for you and your family.

By using you can easily find an up-to-date list of Aciphex prices and coupons from licensed international and Canadian pharmacies online, so you can save up to 90%. 

Order Aciphex from Verified Online Pharmacies

Aciphex and its generic drug counterpart, rabeprazole is lawfully manufactured and distributed in other nations just like it is in the United States. allows you to search for Aciphex pricing from verified pharmacies that list their exact price. At your local U.S. pharmacy, 30 capsules of 20mg Abilify may cost more than $581.63 (unit price $19.38).

At a licensed international or Canadian pharmacy verified by, you may get the same amount of brand name Aciphex for as little as 100 tablets at $65 (unit price $0.77 cents) for significant prescription savings. That's a 96 percent discount vs. the retail price of Aciphex from U.S pharmacies.

The generic form of Abilify, rabeprazole, is also produced and sold lawfully in several countries, including Canada. Many licensed online mail-order pharmacies sell aripiprazole for as low as $21 (unit price $0.23 cents), which is also a significant saving on the unit price.

Use eDrugSearch to Get Free Abilify Coupons

Many free Aciphex coupons are available on our website, for additional savings when you use eDrugSearch to find the lowest prices.

Click the "Coupons" button in the search box to view all licensed international and Canadian online pharmacy names that provide an Aciphex coupon for even greater discounts.

eDrugSearch is an online shopping comparison portal for your Aciphex prescription prices that provides consumers with free price quotes from verified online pharmacies. Making it super easy to compare Abilify prices and order other prescription drugs at the lowest price possible.

Aciphex Patient Assistance Programs

The Aciphex® Patient Assistance Program is a program sponsored by Johnson & Johnson that offers financial assistance to individuals with chronic illnesses in the United States who lack access to prescription drug coverage and fulfill certain financial requirements. Medicare-eligible individuals who qualify for the Aciphex Patient Assistance Program do not qualify for assistance.

How You Can Apply:

Select one of the links below to download the application or go to the program's website for additional information on how to apply. Fill out your application and mail it to the address given on the form.

Free manufacturer coupons or savings cards can also be found at Patients who qualify could pay little as $20 on their next prescription. You can click the link above to go to the website to apply or call 1-877-274-3244.

You can also check out the Rx Outreach Medications on to get more information on their pharmaceutical companies' savings program to reduce your retail price significantly.

Aciphex FAQs

How long can you take Aciphex (rabeprazole)?

For most indications, Aciphex, rabeprazole is meant to be used for up to 8 weeks. While the risk for side effects becomes higher with long-term use, people who have Zollinger-Ellison syndrome or similar conditions will need to take rabeprazole (Aciphex) long-term because the benefits are greater than the risks. If you have concerns about the long-term effects of rabeprazole (Aciphex), you can talk to your healthcare professional about options for lowering your dose or stopping the medication.

Is Aciphex expensive?

The average U.S local pharmacy retail cost for Aciphex tablet 20 mg is around $583 for a supply of 30 tablets, depending on which pharmacy you go to. The prices are only for customers who pay cash and aren't valid with insurance plans.

The average mail-order Canadian pharmacy retail cost for Aciphex tablet 20 mg is around $65 for a supply of 100 tablets, which equals about a 96% discount. 

Can you buy Aciphex over-the-counter?

No, Aciphex (rabeprazole) is not available over-the-counter and must be obtained via prescription from your doctor. Proton pump inhibitors (PPIs) such as Prevacid (lansoprazole), Nexium (esomeprazole), and Prilosec (omeprazole) lower the amount of acid in your stomach, just like Aciphex.

Is Aciphex (rabeprazole) the same as Zantac?

No, rabeprazole (Aciphex) is not the same as Zantac (ranitidine), and they operate in different ways to reduce stomach acid. Zantac, however, is no longer available in the United States. If you're searching for a substitute, famotidine (Pepcid) is comparable. The H2 receptor antagonist Aciphex (rabeprazole) is generally more powerful than ranitidine (Zantac) and famotidine (Pepcid), which are known as histamine H2-receptor antagonists or H2RAs.

What is the best time of day to take Aciphex (rabeprazole)?

Aciphex, rabeprazole can be taken at any time of the day for many indications. After breakfast, it's advised to take rabeprazole (Aciphex) if you've got a duodenal ulcer. If you have H. Pylori and need to take antibiotics, Aciphex should be taken twice a day with breakfast and dinner in addition to the drugs.

Can I drink coffee with Aciphex (rabeprazole)?

Coffee does not interact with rabeprazole (Aciphex) in any way, so you may drink coffee if you choose to. However, coffee can irritate your stomach and cause problems even if you're not sensitive to it. When you're taking medications for your stomach, your provider may advise that you avoid coffee and other caffeine-containing beverages.

Pros and cons of Aciphex (rabeprazole)


  • Most patients simply take the drug once a day, using a tablet delayed release
  • It also comes as a sprinkle capsule for youngsters
  • It may be used for a variety of ailments
  • When used for a short time (4 to 8 weeks), there are practically no negative side effects.
  • Available as a less costly generic alternative


  • Long-term (more than a year) usage might cause undesired side effects
  • This medication might interact with other medicines; it may not be a good choice for those on warfarin
  • Unlike other proton pump inhibitors, it is not available over-the-counter (OTC).
  • It might take a few days to work effectively and doesn't provide fast relief for heartburn symptoms, as fast-acting antacids (TUMS, Rolaids, or Maalox) do

Pharmacist tips for Aciphex

  • Depending on the reason you're using Aciphex (rabeprazole, the generic version), the instructions will differ. Sometimes the medicine is taken with food, other times it's eaten 30 minutes after a meal. Keep a close eye on your prescription label, and ask your doctor or pharmacist if you're unsure how to take it.
  • Make sure the pills are completely consumed and swallowed entirely; do not chew, crush or break them. If they're difficult to swallow, inquire about sprinkle capsules from your doctor or pharmacist.
  • The 'sprinkle' capsules may be opened and sprinkled on a tiny quantity of liquid or soft food such as Pedialyte, apple sauce, yogurt, baby food, or infant formula. Within 15 minutes of combining the medicines with the liquid or food, they should be consumed.
  • Ensure that your dispensary has a complete list of all prescription and non-prescription drugs and supplements you take. Aciphex interacts with a wide range of prescription drugs.
  • If you require fast relief of your heartburn symptoms, you can use antacids (like TUMS or Maalox) with Aciphex (rabeprazole).

Aciphex (rabeprazole) side effects

There are dangers and benefits associated with all medicines. Even if the treatment is effective, you may still experience negative effects.

If you have any of the symptoms described below, contact your doctor right away:

  • C. Difficile Diarrhea - Bad stomach cramps and pain, watery or blood-tinged diarrhea

The following adverse effects are possible and may disappear with time as your body adjusts to the drug. If you continue to experience these symptoms or if they worsen over time, tell your doctor right away.

Common side effects

  • Pain
  • Sore throat
  • Gas
  • Infection
  • Constipation

Other side effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Headache
  • Dry mouth
  • Dizziness
  • Stomach-area (abdomen) pain

Source: FDA

What are the risks and warnings for Aciphex (rabeprazole)?

Aciphex (rabeprazole) has the potential to cause significant health risks. Certain groups may be more vulnerable to this danger. If you're worried about this, talk to your doctor or pharmacist about alternative drug treatments.


Heartburn, GERD, and other stomach discomfort symptoms might be indications of more significant stomach issues or cancer. However, your doctor may have to perform some additional tests to confirm this. If your stomach issues don't go away completely with rabeprazole (Aciphex), or if your symptoms return aggressively after stopping the treatment, talk to your doctor immediately. 


It's uncommon, but some people who take PPIs like Aciphex (rabeprazole) have developed lupus or had their existing lupus symptoms worsen. Lupus can affect people in different ways, but some typical symptoms include joint and muscular discomfort as well as a rash. If you experience any of these symptoms talk to your doctor right away. They may conduct tests to see whether the condition is due to the drug. After several weeks, when the medication is discontinued, your symptoms should generally improve.


Aciphex or rabeprazole might cause interactions with a variety of medicines, vitamins, and herbal treatments. HIV medications that include rilpivirine can't be combined with Aciphex (rabeprazole). Some drugs should be avoided, such as St. John's Wort, rifampin, and methotrexate. If you're taking Coumadin, notify your Coumadin doctor if you're planning to start rabeprazole (Aciphex). Because the condition only affects certain people, it may be more difficult to treat. It may also cause your INR to fluctuate, so they will want to monitor you more closely. Verify that all of your service providers have a complete list of the medications you're taking so they can check for drug interactions.


Proton pump inhibitors (PPIs) can cause sudden (acute) kidney damage, which might occur at any point during therapy. If you detect blood in your urine, changes in how much urine you produce, nausea, or a loss of appetite, contact your doctor right away.


  • Risk factors include taking large doses of PPIs and also taking PPIs for more than a year

Rabeprazole (Aciphex) can cause osteoporosis-related bone fractures in some people. The danger is greater for individuals who take PPIs in large doses for more than a year. The greatest approach to reduce your danger is to take the lowest dose of rabeprazole (Aciphex) for the shortest amount of time. If you have to take the drug for a long period of time, talk to your doctor about drugs or supplements that may help you decrease your risk.


  • Risk factors include being treated at a hospital

Although this medication is intended to decrease acidity, it may induce a bacterial infection that causes severe diarrhea, especially if you're admitted to the hospital. If you have symptoms like watery diarrhea, a fever, or stomach discomfort that doesn't go away, contact your doctor immediately. To reduce your danger, take Aciphex (rabeprazole) in the lowest dose and for the shortest period of time possible.


  • Risk factors include long-term therapy with stomach acid lowering drugs

It's unusual, but Aciphex (rabeprazole) can lower blood magnesium and vitamin B12 levels. This may occur after only a few months of therapy, but it is more common after a year. Make certain that you have your levels checked regularly so that your doctor can monitor them. If your levels drop too far, they can prescribe you supplements if needed. 

Interactions between Aciphex (rabeprazole) and other prescription drugs

Aciphex (rabeprazole) may cause problems when taken with certain medicines or supplements. If you're taking any other medicines or supplements, tell your doctor and pharmacist; this includes both prescription and over-the-counter medications, vitamins, and dietary and herbal supplements. The following list does not include all of Aciphex, rabeprazole's possible drug interactions. Only the generic name of each medication is included below, rather than the brand name.

If your face, mouth, or tongue begins to expand and you can't breathe, call your doctor immediately since this might be a serious allergic reaction to Aciphex.

This drug should not be used in combination with any of the following drugs. Your doctor may decide not to treat you with this medication or change one or more other medicines you are taking.

  • Rilpivirine

Using this medicine with any of the following medicines is usually not advised, however it may be required in certain circumstances. If you take both drugs at the same time, your doctor or pharmacist may alter the dosage or how often you use one or both of them.

Using this medicine with any of the following medicines may raise the likelihood of some side effects, but using them both may be the best course of treatment for you. If you take two medicines at the same time, your doctor may alter the dosage or how often you take one or both of them.

More Information

The 'Total Cost' above includes delivery costs, which are typically applied to the entire order, making it more cost-effective to buy numerous prescription drugs in one order.

Individuals who order non-controlled prescription medicines from Canada or other foreign sources (up to a three-month supply) for their own personal use are not being pursued or convicted by the government, according to U.S. officials. Although the practice is technically not legal for individuals to import prescription drugs.

The FDA, or Food and Drug Administration, is a government agency in the United States that regulates the safety and effectiveness of drugs sold in American pharmacies. Pharmaceutical/pharmacy regulatory authorities in other countries regulate the safety and efficacy of medicines dispensed from outside the United States.

Find out how regulations differ by each country.

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