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Zepbound Cost Without Insurance and With Medicare
- Lowest U.S. online pharmacy price
- $349.75 per weekly dose$4,496.79 for 90 days, shipping included · FDA-approved brand Zepbound 5 mg · ships within the U.S.
- Lowest international online pharmacy price
- $122.50 per weekly dose$1,607.07 for 90 days, shipping included · brand Zepbound 5 mg, not FDA-approved · ships from Canada
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Quick answerAs of Nov 12, 2026, Lilly's U.S. self-pay price for Zepbound is $299 to $449 a month by dose if you refill within 45 days, less than brand Zepbound 5 mg from licensed pharmacies abroad, from $1,607.07 for 90 days. The U.S. list price is $1,086.37 for 4 pens.
Name check: Mounjaro is the same medicine (tirzepatide) approved for type 2 diabetes, and it has its own page. Compounded tirzepatide is not FDA-approved.
Zepbound may cost less in the U.S.
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
The lowest price in our table is $1,607.07 (ships from Canada), shipping included. These programs can cost less:
- LillyDirect self-pay (Eli Lilly), also listed on TrumpRx: Zepbound KwikPen or single-dose vials: $299 for 2.5 mg, $399 for 5 mg and $449 for 7.5 mg, 10 mg, 12.5 mg or 15 mg for each 28-day supply (1 KwikPen or 4 vials), when you refill within 45 days. Late refills: $499 for 7.5 mg and $699 for 10 mg to 15 mg. 90 days of 5 mg works out to about $1,283. Insurance is not billed. With Medicare or Medicaid, you can pay this cash price, but it won't count toward your plan. $1,283 for 90 days (LillyDirect) (TrumpRx.gov)
We list these because they may save you money. No one pays us to include them. Prices and eligibility rules change, so confirm before you buy. Checked Nov 12, 2026.
Compare Zepbound prices from licensed online pharmacies
Ships cold: Zepbound needs refrigerated shipping (36°F to 46°F, 2°C to 8°C) before first use, per its U.S. label. Check that the pharmacy ships it cold.
Source: U.S. prescribing information on DailyMed, checked Nov 14, 2026. Each price below says whether we confirmed cold shipping on the pharmacy's own shipping or FAQ page.
For comparison U.S. pharmacy list price: $3,491.91 for 90 days ($271.59 per weekly dose), brand Zepbound 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg or 15 mg before insurance. The prices below are from U.S. pharmacies that publish cash prices and from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per weekly doseLicensed Canadian pharmacy A | Zepbound KwikPen (4 weekly doses per pen)2.5 mg · brand · Filled in CanadaProduct of CanadaCold shipping: not confirmed | $1,469.94for 12 weekly doses$122.50 per weekly dose | $29.99Delivery time not stated | $1,499.93 for 84 days= $1,607.07 for 90 daysSave 54%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed Canadian pharmacy A | Zepbound KwikPen (4 weekly doses per pen)5 mg · brand · Filled in CanadaProduct of CanadaCold shipping: not confirmed | $1,469.94for 12 weekly doses$122.50 per weekly dose | $29.99Delivery time not stated | $1,499.93 for 84 days= $1,607.07 for 90 daysSave 54%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed Canadian pharmacy A | Zepbound KwikPen (4 weekly doses per pen)7.5 mg · brand · Filled in CanadaProduct of CanadaCold shipping: not confirmed | $1,769.94for 12 weekly doses$147.50 per weekly dose | $29.99Delivery time not stated | $1,799.93 for 84 days= $1,928.50 for 90 daysSave 45%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed Canadian pharmacy A | Zepbound KwikPen (4 weekly doses per pen)10 mg · brand · Filled in CanadaProduct of CanadaCold shipping: not confirmed | $1,769.94for 12 weekly doses$147.50 per weekly dose | $29.99Delivery time not stated | $1,799.93 for 84 days= $1,928.50 for 90 daysSave 45%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed Canadian pharmacy A | Zepbound KwikPen (4 weekly doses per pen)12.5 mg · brand · Filled in CanadaProduct of CanadaCold shipping: not confirmed | $2,069.94for 12 weekly doses$172.50 per weekly dose | $29.99Delivery time not stated | $2,099.93 for 84 days= $2,249.93 for 90 daysSave 36%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed Canadian pharmacy A | Zepbound KwikPen (4 weekly doses per pen)15 mg · brand · Filled in CanadaProduct of CanadaCold shipping: not confirmed | $2,069.94for 12 weekly doses$172.50 per weekly dose | $29.99Delivery time not stated | $2,099.93 for 84 days= $2,249.93 for 90 daysSave 36%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed U.S. pharmacy B | Zepbound single-dose pens (1 weekly dose each)15 mg · brandMaker listed by pharmacy: Eli LillyShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026Cold shipping: not confirmed | $1,399per 4 weekly doses · 3 packs = $4,197$349.75 per weekly dose | FreePharmacy's estimate: 7–10 business days | $4,197 for 84 days= $4,496.79 for 90 daysWorked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed U.S. pharmacy B | Zepbound single-dose pens (1 weekly dose each)2.5 mg · brandMaker listed by pharmacy: Eli LillyShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026Cold shipping: not confirmed | $1,399per 4 weekly doses · 3 packs = $4,197$349.75 per weekly dose | FreePharmacy's estimate: 7–10 business days | $4,197 for 84 days= $4,496.79 for 90 daysWorked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed U.S. pharmacy B | Zepbound single-dose pens (1 weekly dose each)10 mg · brandMaker listed by pharmacy: Eli LillyShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026Cold shipping: not confirmed | $1,399per 4 weekly doses · 3 packs = $4,197$349.75 per weekly dose | FreePharmacy's estimate: 7–10 business days | $4,197 for 84 days= $4,496.79 for 90 daysWorked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed U.S. pharmacy B | Zepbound single-dose pens (1 weekly dose each)5 mg · brandMaker listed by pharmacy: Eli LillyShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026Cold shipping: not confirmed | $1,399per 4 weekly doses · 3 packs = $4,197$349.75 per weekly dose | FreePharmacy's estimate: 7–10 business days | $4,197 for 84 days= $4,496.79 for 90 daysWorked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed U.S. pharmacy B | Zepbound single-dose pens (1 weekly dose each)7.5 mg · brandMaker listed by pharmacy: Eli LillyShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026Cold shipping: not confirmed | $1,399per 4 weekly doses · 3 packs = $4,197$349.75 per weekly dose | FreePharmacy's estimate: 7–10 business days | $4,197 for 84 days= $4,496.79 for 90 daysWorked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per weekly doseLicensed U.S. pharmacy B | Zepbound single-dose pens (1 weekly dose each)12.5 mg · brandMaker listed by pharmacy: Eli LillyShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026Cold shipping: not confirmed | $1,399per 4 weekly doses · 3 packs = $4,197$349.75 per weekly dose | FreePharmacy's estimate: 7–10 business days | $4,197 for 84 days= $4,496.79 for 90 daysWorked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Zepbound from Canada?
90-day cost = 12.9 weekly doses at the usual dose of 1 a week, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 12, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price of the same strength (2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg or 15 mg). The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, for whole fills, plus its standard shipping; no insurance or discount cards.
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Join to See PharmaciesAlready a member? Sign inZepbound price by strength
| Strength | Lowest brand90 days | Price per weekly dose |
|---|---|---|
| Zepbound 2.5 mg | $1,607.07 | $122.50 |
| Zepbound 5 mg | $1,607.07 | $122.50 |
| Zepbound 7.5 mg | $1,928.50 | $147.50 |
| Zepbound 10 mg | $1,928.50 | $147.50 |
| Zepbound 12.5 mg | $2,249.93 | $172.50 |
| Zepbound 15 mg | $2,249.93 | $172.50 |
Lowest 90-day cost with shipping at licensed pharmacies shipping to the U.S. now, counting only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price per weekly dose is for that lowest pack, before shipping. Prices checked Nov 12, 2026.
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90-day prices from 1 licensed pharmacy abroad shipping to the U.S.: $1,607.07 to $2,249.93, any strength, shipping included.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Zepbound · Similar drugs · Uses · FAQ
Zepbound (tirzepatide) weekly injection: Lilly's self-pay prices by dose, the U.S. list price, the $25 savings card, Medicare's GLP-1 Bridge and prices from licensed pharmacies abroad.
Zepbound cost at a glance
- Self-pay from Lilly (KwikPen or vials): $299 for 2.5 mg, $399 for 5 mg and $449 for 7.5 mg, 10 mg, 12.5 mg or 15 mg a month (28 days), if you refill within 45 days. Late refills of 7.5 mg cost $499, and 10 mg to 15 mg cost $699 (LillyDirect).
- U.S. list price: $1,086.37 for 4 single-dose pens (28 days), about $3,492 for 90 days (Texas DSHS).
- With private insurance: the Zepbound Savings Card may lower your cost to as little as $25 for a 1- or 3-month supply of single-dose pens (Lilly).
- With Medicare: the Medicare GLP-1 Bridge covers Zepbound KwikPen for eligible people for a $50 copay per month, July 1, 2026 to December 31, 2027 (Medicare.gov).
- How we count: 1 dose a week. A single-dose pen or vial is 1 dose; a KwikPen holds 4 weekly doses, so 3 KwikPens last 84 days.
- From licensed pharmacies abroad: $1,607.07 for 90 days of brand Zepbound 5 mg, refrigerated shipping included (checked Nov 12, 2026). Packs made for other countries are not FDA-approved.
How much does Zepbound cost in the U.S.?
| If you have | What Zepbound costs | Source |
|---|---|---|
| No insurance (self-pay) | $299 for 2.5 mg, $399 for 5 mg and $449 for 7.5 mg, 10 mg, 12.5 mg or 15 mg a month for the KwikPen or vials through LillyDirect (refill within 45 days). | Eli Lilly |
| No insurance (list price) | $1,086.37 for 4 single-dose pens (28 days). Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| Private or employer insurance | As little as $25 for a 1- or 3-month supply of single-dose pens with the Zepbound Savings Card, if your plan covers Zepbound. Many plans don't cover weight-loss medicines. | Lilly |
| Medicare (GLP-1 Bridge) | Zepbound KwikPen for a $50 copay per month for eligible people, July 1, 2026 to December 31, 2027, with prior authorization. People with type 2 diabetes, moderate-to-severe sleep apnea or fatty liver disease aren't eligible for the Bridge; their Part D plan may cover Zepbound instead. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Lilly gives Zepbound's list price as $499 to $1,086.37 per fill depending on the form (Lilly); the Texas DSHS 2026 report lists the 4-pen carton at $1,086.37 for every dose (Texas DSHS). That's the maker's wholesale price before discounts. Lilly's self-pay prices for the KwikPen and vials are lower.
Zepbound cost with Medicare in 2026
By law, Medicare drug plans generally can't cover medicines used only for weight loss. Medicare's GLP-1 Bridge, which runs from July 1, 2026 to December 31, 2027, covers Zepbound KwikPen for eligible people for a $50 copay per month, with prior authorization from your provider. People with type 2 diabetes, moderate-to-severe sleep apnea or fatty liver disease aren't eligible for the Bridge, but their Part D plan may cover Zepbound.
| Medicare Part D | What Zepbound costs | Source |
|---|---|---|
| GLP-1 Bridge | $50 copay per month for Zepbound KwikPen, for eligible people, July 1, 2026 to December 31, 2027 | Medicare.gov |
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Zepbound coupons and savings programs
eDrugSearch does not offer its own Zepbound coupons. eDrugSearch has no coupons of its own. These programs can help:
- Zepbound Savings Card: for people with commercial insurance. You may pay as little as $25 for a 1- or 3-month supply of Zepbound single-dose pens, with monthly and yearly limits. Not for Medicare, Medicaid or other government programs. (Lilly)
- LillyDirect self-pay: $299 for 2.5 mg, $399 for 5 mg and $449 for 7.5 mg, 10 mg, 12.5 mg or 15 mg a month for the KwikPen or vials when refilled within 45 days. (LillyDirect)
- Medicare GLP-1 Bridge: Zepbound KwikPen for a $50 copay per month for eligible people with Medicare, through December 31, 2027. The copay doesn't count toward your deductible or out-of-pocket cap, and Extra Help can't lower it. (Medicare.gov)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Zepbound?
No. The FDA has not approved a generic Zepbound. Drugs@FDA lists no generic tirzepatide; the only tirzepatide products are Lilly's Zepbound and Mounjaro.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 2.5 mg | No | — | |
| 5 mg | No | — | |
| 7.5 mg | No | — | |
| 10 mg | No | — | |
| 12.5 mg | No | — | |
| 15 mg | No | — |
Outside the U.S.: Licensed pharmacies abroad sell Lilly's own Zepbound KwikPen made for Canada. It is not FDA-approved for sale in the U.S., and the price table labels it that way.
Source: Drugs@FDA: Zepbound (NDA 217806). As of Nov 14, 2026.
Compare Zepbound with similar drugs
Other GLP-1 medicines with price pages here: Wegovy (semaglutide) and Saxenda (liraglutide) are approved for weight loss, Mounjaro is tirzepatide for type 2 diabetes, and Ozempic is semaglutide for type 2 diabetes.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Wegovysemaglutide | Weight-loss and heart-risk medicine (GLP-1 receptor agonist) | $7,716.25 for 90 days | See prices |
| Mounjarotirzepatide | Type 2 diabetes medicine (GIP and GLP-1 receptor agonist), once-weekly injection | $1,607.07 for 90 days | See prices |
| Ozempicsemaglutide | Diabetes medicine (GLP-1 receptor agonist), once-weekly injection | $642.78 for 90 days | See prices |
| Saxendaliraglutide | Weight-management medicine (GLP-1 receptor agonist), once-daily injection | $1,544.93 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Zepbound used for?
Zepbound (tirzepatide) is a once-weekly injection that acts on two gut hormones, GIP and GLP-1. According to its FDA label (DailyMed), it is used with a reduced-calorie diet and more physical activity:
- To reduce excess body weight and keep it off in adults with obesity, or adults with overweight and at least one weight-related health problem.
- To treat moderate to severe obstructive sleep apnea in adults with obesity.
The label starts at 2.5 mg once a week for 4 weeks (a starting dose only), then goes up in 2.5 mg steps every 4 weeks or more. Maintenance doses are 5 mg, 10 mg or 15 mg for weight, and 10 mg or 15 mg for sleep apnea. Zepbound comes as single-dose pens (4 to a carton), single-dose or multi-dose vials, and a KwikPen that holds 4 weekly doses. It has a boxed warning about thyroid C-cell tumors. Your prescriber decides which medicine is right for you.
Is it safe to order Zepbound from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Zepbound, Lilly's U.S. self-pay price is usually lower. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. Zepbound it has to stay cold until first use, so pick a pharmacy that ships it refrigerated. Health Canada lists Zepbound from Eli Lilly Canada as marketed in all six doses (Health Canada Drug Product Database, checked 2026-11-14). Each Canadian KwikPen holds 4 weekly doses.
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much does Zepbound cost without insurance?
Lilly's self-pay price for the KwikPen or vials is $299 a month for 2.5 mg, $399 for 5 mg and $449 for 7.5 mg to 15 mg if you refill within 45 days. The U.S. list price is $1,086.37 for 4 single-dose pens. Licensed pharmacies abroad charged from $1,607.07 for 90 days of brand Zepbound 5 mg in our latest check (Nov 12, 2026).
Is Zepbound cheaper from Canada?
Not in our latest check. Lilly's U.S. self-pay prices for the KwikPen and vials cost less than the brand Zepbound KwikPens we found at licensed pharmacies abroad, which also need refrigerated shipping.
Does Medicare cover Zepbound?
Through Medicare's GLP-1 Bridge (July 1, 2026 to December 31, 2027), eligible people can get Zepbound KwikPen for a $50 copay per month with prior authorization. People with type 2 diabetes, moderate-to-severe sleep apnea or fatty liver disease aren't eligible for the Bridge, but their Part D plan may cover Zepbound.
How do I get Zepbound for $25?
With commercial insurance, the Zepbound Savings Card may lower your cost to as little as $25 for a 1- or 3-month supply of single-dose pens, with monthly and yearly limits. It can't be used with Medicare or Medicaid.
How long does a Zepbound KwikPen last?
A KwikPen holds 4 weekly doses, so it lasts 28 days. Lilly's self-pay month is 1 KwikPen or 4 vials.
Is there a generic Zepbound?
No. The FDA has not approved a generic tirzepatide. Compounded tirzepatide is not FDA-approved.
Sources
- Zepbound U.S. prescribing information (DailyMed) (Eli Lilly label version 40, effective 2026-08-28: weight and sleep apnea uses, doses, single-dose pens, vials, KwikPen (4 doses), storage)
- Drugs@FDA: Zepbound (NDA 217806) (no ANDA for tirzepatide)
- FDA NDC Directory: Zepbound (4-pen cartons, 1- and 4-vial cartons, multi-dose vials and KwikPens (from 2026-01-20))
- LillyDirect: Zepbound self-pay ($299/$399/$449 within 45 days; late refill $499/$699; month = 28 days (page modified 2026-10-30, read 2026-11-14))
- Lilly: Zepbound cost information (list price $499 to $1,086.37 per fill; savings card for single-dose pens)
- Texas DSHS 2026 WAC report: Zepbound (4-pen cartons and 4-vial cartons at $1,086.37)
- TrumpRx.gov: Zepbound (vials, same self-pay prices (read 2026-11-14))
- Medicare.gov: weight-loss drugs and the GLP-1 Bridge (Zepbound KwikPen, $50 copay, eligibility (read 2026-11-14))
- Health Canada Drug Product Database: Zepbound (DINs 02557509-02557568, Eli Lilly Canada, Marketed)
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.