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Orilissa Cost, Generic and Savings
- Lowest U.S. online pharmacy price
- $48.13 per tablet$4,336.86 for 90 days (90 tablets), shipping included · FDA-approved brand Orilissa 150 mg · ships within the U.S.
- Lowest international online pharmacy price
- $7.21 per tablet$648.77 for 90 days (90 tablets), plus shipping (fee not published) · brand Orilissa 150 mg, not FDA-approved · ships from Canada
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Quick answerAs of Nov 12, 2026, brand Orilissa 150 mg costs from $776.25 for 90 days at online pharmacies abroad we compared, vs. $3,894.56 at the U.S. list price ($1,211.64 per 28 tablets). No generic Orilissa is sold in the U.S.
Name check: Orilissa 150 mg is taken once a day. The 200 mg tablet is taken twice a day, so its 4-week box holds 56 tablets instead of 28.
Compare Orilissa prices from licensed online pharmacies
For comparison U.S. pharmacy list price: $3,894.57 for 90 days ($43.27 per tablet), brand Orilissa 150 mg before insurance. The prices below are from U.S. pharmacies that publish cash prices and from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per tabletOnline pharmacy A | Orilissa150 mg · brand · Filled in CanadaProduct of Canada | $201.84per 28 tablets · 3 packs = $605.52$7.21 per tablet | Fee not publishedDelivery time not stated | $605.52 for 84 days= $648.77 for 90 days+ shippingSave 83%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy A | Orilissa200 mg · brand · Filled in CanadaProduct of Canada | $414.32for 56 tablets$7.40 per tablet | Fee not publishedDelivery time not stated | $414.32 for 56 days= $665.87 for 90 days+ shippingWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy B | Orilissa200 mg · brand · Filled in CanadaProduct of Canada | $424.99for 56 tablets$7.59 per tablet | Fee not publishedDelivery time not stated | $424.99 for 56 days= $683.02 for 90 days+ shippingWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy B | Orilissa150 mg · brand · Filled in CanadaProduct of Canada | $212.99per 28 tablets · 3 packs = $638.97$7.61 per tablet | Fee not publishedDelivery time not stated | $638.97 for 84 days= $684.61 for 90 days+ shippingSave 82%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | Orilissa (United States pack, ships from Canada)200 mg · brand · Filled in CanadaMaker listed by pharmacy: Abbvie Corp.Made for United States | $459for 56 tablets$8.20 per tablet | $9.95Pharmacy's estimate: 4–6 weeks | $468.95 for 56 days= $753.67 for 90 daysWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed Canadian pharmacy D | Orilissa150 mg · brand · Filled in CanadaMaker listed by pharmacy: ABBVIE CORPORATION | $714.55for 84 tablets$8.51 per tablet | $9.95Pharmacy's estimate: 3–6 weeks | $724.50 for 84 days= $776.25 for 90 daysSave 80%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed Canadian pharmacy D | Orilissa200 mg · brand · Filled in CanadaMaker listed by pharmacy: ABBVIE CORPORATION | $486.18for 56 tablets$8.68 per tablet | $9.95Pharmacy's estimate: 3–6 weeks | $496.13 for 56 days= $797.35 for 90 daysWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed Canadian pharmacy E | Orilissa (Elagolix Sodium)200 mg · brand · Filled in CanadaProduct of Canada | $499.95for 56 tablets$8.93 per tablet | $14.99Delivery time not stated | $514.94 for 56 days= $827.58 for 90 daysWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed Canadian pharmacy E | Orilissa (Elagolix Sodium)150 mg · brand · Filled in CanadaProduct of Canada | $794.94for 84 tablets$9.46 per tablet | $14.99Delivery time not stated | $809.93 for 84 days= $867.78 for 90 daysSave 78%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | Orilissa (United States pack, ships from Canada)150 mg · brand · Filled in CanadaMaker listed by pharmacy: Abbvie Corp.Made for United States | $840for 84 tablets$10.00 per tablet | $9.95Pharmacy's estimate: 4–6 weeks | $849.95 for 84 days= $910.66 for 90 daysSave 77%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy F | ORILISSA (USA pack, ships from Canada)200 mg · brand · Filled in CanadaProduct of USA | $680.33for 56 tablets$12.15 per tablet | FreeDelivery time not stated | $680.33 for 56 days= $1,093.39 for 90 daysWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy G | ORILISSA 150MG TABLET 84 (BRAND FROM CANADA)150 mg · brand · Filled in CanadaProduct of Canada | $1,006for 84 tablets$11.98 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $1,020.95 for 84 days= $1,093.88 for 90 daysSave 72%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy G | ORILISSA 200MG TABLET 56 (BRAND FROM CANADA)200 mg · brand · Filled in CanadaProduct of Canada | $682for 56 tablets$12.18 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $696.95 for 56 days= $1,120.10 for 90 daysWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy H | ORILISSA (USA pack, ships from Canada)200 mg · brand · Filled in CanadaProduct of USA | $716.14for 56 tablets$12.79 per tablet | FreeDelivery time not stated | $716.14 for 56 days= $1,150.94 for 90 daysWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy F | ORILISSA (USA pack, ships from Canada)150 mg · brand · Filled in CanadaProduct of USA | $359.40per 28 tablets · 3 packs = $1,078.20$12.84 per tablet | FreeDelivery time not stated | $1,078.20 for 84 days= $1,155.21 for 90 daysSave 70%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy I | Orilissa150 mg · brand · Filled in CanadaProduct of Canada | $366.80per 28 tablets · 3 packs = $1,100.40$13.10 per tablet | $9.95Delivery time not stated | $1,110.35 for 84 days= $1,189.66 for 90 daysSave 69%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy I | Orilissa200 mg · brand · Filled in CanadaProduct of Canada | $732.94for 56 tablets$13.09 per tablet | $9.95Delivery time not stated | $742.89 for 56 days= $1,193.93 for 90 daysWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy H | ORILISSA (USA pack, ships from Canada)150 mg · brand · Filled in CanadaProduct of USA | $378.32per 28 tablets · 3 packs = $1,134.96$13.51 per tablet | FreeDelivery time not stated | $1,134.96 for 84 days= $1,216.03 for 90 daysSave 69%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy J | Orilissa 200mg Blister Pack of 56 Tablets200 mg · brandU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026 | $1,347.58for 56 tablets$24.06 per tablet | $5Pharmacy's estimate: 2–8 business days | $1,352.58 for 56 days= $2,173.79 for 90 daysWorked out from a 56-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletLicensed U.S. pharmacy J | Orilissa 150mg Blister Pack of 28 Tablets150 mg · brandU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026 | $1,347.58per 28 tablets · 3 packs = $4,042.74$48.13 per tablet | $5Pharmacy's estimate: 2–8 business days | $4,047.74 for 84 days= $4,336.86 for 90 daysWorked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Orilissa from Canada?
90-day cost = 90 tablets at the usual dose of 1 a day, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 12, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price of the same strength (150 mg); rows for other strengths show no saving. The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, for whole fills, plus its standard shipping; no insurance or discount cards. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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Join to See PharmaciesAlready a member? Sign inOrilissa price by strength
| Strength | Lowest brand90 days | Price per tablet |
|---|---|---|
| Orilissa 150 mg | $776.25 | $8.51 |
| Orilissa 200 mg | $753.67 | $8.20 |
Lowest 90-day cost with shipping at licensed pharmacies shipping to the U.S. now, counting only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price per tablet is for that lowest pack, before shipping. Prices checked Nov 12, 2026.
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90-day prices from 7 licensed pharmacies abroad shipping to the U.S.: $753.67 to $1,216.03, any strength, shipping included.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Orilissa · Similar drugs · Uses · FAQ
Orilissa (elagolix) 150 mg and 200 mg tablets for moderate to severe endometriosis pain. No generic Orilissa is sold in the U.S.
Orilissa cost at a glance
- U.S. list price: $1,211.64 for a 4-week box of brand Orilissa, either strength: 28 tablets of 150 mg or 56 tablets of 200 mg. At 1 tablet a day of 150 mg, that's about $1,298.19 for 30 days or $3,894.56 for 90 days. These are the maker's wholesale prices before discounts (Texas DSHS).
- No U.S. generic. The FDA hasn't approved a generic elagolix tablet, so AbbVie's Orilissa is the only version sold in the U.S. (FDA Orange Book).
- How we count: 1 tablet a day of 150 mg, the label's starting dose. The 200 mg dose is 1 tablet twice a day, so 90 days of 200 mg takes 180 tablets. Our 90-day prices for 200 mg count 1 tablet a day, so double them for the twice-daily 200 mg dose.
- With commercial insurance: the Orilissa Savings Card may lower your cost to as little as $5 a month, up to $5,000 a year. It isn't for Medicare, Medicaid or other government plans (Orilissa.com).
- From online pharmacies abroad: $776.25 to $1,216.03 for 90 days of brand Orilissa 150 mg, shipping included (checked Nov 12, 2026). The U.S. list price for the same 90 days is $3,894.56.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Orilissa cost in the U.S.?
| If you have | What Orilissa costs | Source |
|---|---|---|
| No insurance (list price) | $1,211.64 for a 4-week box of brand Orilissa (28 tablets of 150 mg, or 56 tablets of 200 mg). Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan. The Orilissa Savings Card may bring it down to as little as $5 a month, up to $5,000 a year. Maker co-pay programs can't be used with Medicare, Medicaid or other government insurance. | Orilissa.com |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Orilissa lists at $1,211.64 for a 4-week box in the U.S., the same for both strengths (Texas DSHS). The 150 mg box holds 28 tablets, about $43.27 a tablet; the 200 mg box holds 56 tablets because that dose is taken twice a day. At 1 tablet a day of 150 mg, 90 days comes to $3,894.56 at list price. These are list prices (the maker's wholesale price before discounts); what a pharmacy charges can differ.
Orilissa cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for Orilissa depends on your plan's drug list. The Orilissa Savings Card can't be used with Medicare.
| Medicare Part D | What Orilissa costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Orilissa coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
eDrugSearch does not offer its own Orilissa coupons. These are the programs we could verify for Orilissa:
- Orilissa Savings Card: if you have commercial (private or employer) insurance that covers Orilissa, you may pay as little as $5 a month. The most the card pays is $5,000 a year. It can't be used if any federal, state or government program, such as Medicare, Medicaid or TRICARE, pays for your prescriptions. Call 1-800-674-5477 (1-800-ORILISSA). (Orilissa.com)
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Orilissa?
No. The FDA has not approved a generic elagolix tablet. AbbVie's Orilissa is the only version sold in the U.S.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 150 mg | No | — | |
| 200 mg | No | — |
Outside the U.S.: We haven't seen generic elagolix at the online pharmacies we compare. Brand Orilissa packs sold abroad are made for other countries, and the price table shows each pack's country.
Source: FDA Orange Book: elagolix products. As of Nov 12, 2026.
Compare Orilissa with similar drugs
Myfembree (relugolix, estradiol and norethindrone acetate) is another once-a-day pill for moderate to severe endometriosis pain. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Myfembreerelugolix, estradiol and norethindrone acetate | Uterine fibroid and endometriosis medicine (GnRH receptor antagonist with an estrogen and a progestin) | $703.28 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Orilissa used for?
Orilissa (elagolix) is a GnRH receptor antagonist. According to its FDA label (DailyMed), it is used for:
- The management of moderate to severe pain associated with endometriosis.
Orilissa comes as 150 mg and 200 mg tablets in weekly blister packs. The label's doses are 150 mg once a day for up to 24 months, or 200 mg twice a day for up to 6 months; the time limits are there because Orilissa can cause bone loss. People with moderate liver problems take only 150 mg once a day, for up to 6 months. The label says not to use Orilissa during pregnancy, with known osteoporosis, with severe liver problems, or with certain medicines that raise elagolix levels. Orilissa does not prevent pregnancy. Your prescriber decides which medicine is right for you.
Is it safe to order Orilissa from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Orilissa, check whether the Orilissa Savings Card covers you before you order. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Orilissa 150 mg and 200 mg tablets are sold under the same name by AbbVie Corporation (Health Canada).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much does Orilissa cost without insurance?
The U.S. list price of brand Orilissa is $1,211.64 for a 4-week box (28 tablets of 150 mg), about $3,894.56 for 90 days at 1 tablet a day. Online pharmacies abroad charged from $776.25 for 90 days of brand Orilissa 150 mg in our latest check (Nov 12, 2026), shipping included.
Is there a generic Orilissa?
No. The FDA hasn't approved a generic elagolix tablet, so Orilissa is the only version sold in the U.S.
Is there an Orilissa savings card?
Yes, for people with commercial insurance. The Orilissa Savings Card may lower your cost to as little as $5 a month, up to $5,000 a year. It can't be used with Medicare, Medicaid or other government insurance. eDrugSearch doesn't offer coupons of its own.
How much does Orilissa cost with Medicare?
It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. People with limited income can apply for Extra Help.
How many Orilissa tablets do you take a day?
The label's doses are 150 mg once a day (1 tablet) or 200 mg twice a day (2 tablets). This page counts 1 tablet a day of 150 mg, so 90 tablets last 90 days.
How long can you take Orilissa?
The label limits use because Orilissa can cause bone loss: up to 24 months at 150 mg once a day, or up to 6 months at 200 mg twice a day. Your prescriber decides how long you take it.
Is Orilissa sold in Canada?
Yes. Health Canada lists Orilissa 150 mg and 200 mg tablets as marketed by AbbVie. Packs made for other countries are not FDA-approved, and the price table shows each pack's country.
Sources
- ORILISSA U.S. prescribing information (DailyMed) (AbbVie, label version 112, effective 2025-12-19: endometriosis pain; 150 mg once daily up to 24 months or 200 mg twice daily up to 6 months; contraindications; 28-tablet (150 mg) and 56-tablet (200 mg) 4-week cartons)
- FDA Orange Book: elagolix products (ORILISSA N210450 (AbbVie) 150 mg and 200 mg tablets, RX; no generic (ANDA) elagolix tablets (October 2026 data files))
- FDA NDC Directory: Orilissa (0074-0038-28 (150 mg, 28 tablets) and 0074-0039-56 (200 mg, 56 tablets), marketed since July 23, 2018; not a controlled substance)
- Texas DSHS: 2026 annual WAC report (AbbVie ORILISSA 00074003828 (150 mg x28) $1,211.64; 00074003956 (200 mg x56) $1,211.64)
- Orilissa Savings Card (as little as $5 a month with commercial insurance; up to $5,000 per calendar year; not for federal, state or government-funded insurance; 1-800-674-5477; checked 2026-11-12)
- Health Canada Drug Product Database: Orilissa (DIN 02481332 (150 mg) and 02481340 (200 mg), AbbVie Corporation, Marketed; checked 2026-11-12)
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.