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Opzelura Price (ruxolitinib)
As of Nov 5, 2026, brand Opzelura 1.5% cream costs from $13.26 per g at licensed pharmacies abroad, before shipping (packs made for other countries are not FDA-approved). The U.S. list price is $2,136 for a 60 g tube.
- Lowest price per g at U.S. online pharmacies
- Not available
- Lowest price per g at online pharmacies abroad
- $13.26 per gIn a pack of 300 g for $3,979 (before shipping) · brand Opzelura 1.5%, not FDA-approved · ships from Canada
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Name check: Jakafi tablets (sold as Jakavi in Canada and Europe) also contain ruxolitinib but are taken by mouth for blood disorders. They are not interchangeable with Opzelura cream.
Compare Opzelura prices from licensed pharmacies
| Pharmacy | Medication | Pack | Price per unit | Pack price | Shipping & delivery | Total with shipping | Buy |
|---|---|---|---|---|---|---|---|
| Lowest price per unitLicensed Canadian pharmacy A | Opzelura Cream1.5% · brand · Filled in CanadaMaker listed by pharmacy: INCYTE CORPORATION | 300 g2 other pack sizes
| $13.26 per g | $3,979 | $9.95Pharmacy's estimate: 3–6 weeks | $3,988.95Checked Nov 7 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy B | Opzelura 1.5% Cream (UK/EU pack, ships from United Kingdom)1.5% · brand · Filled in United KingdomMaker listed by pharmacy: Maker not shown by pharmacyMade for UK/EU | 100 g | $16.90 per g | $1,690.18 | Fee not publishedDelivery time not stated | $1,690.18+ shippingChecked Nov 5 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Opzelura from Canada?
Each row is one product from one pharmacy, shown in the pack size with the lowest price per unit; its other pack sizes are listed under “other pack sizes”. Price per unit = the pack price divided by the units in the pack, before shipping; we sort by it and don't assume how long a pack lasts. Total with shipping = the pack price plus the pharmacy's shipping fee for one order. Prices checked Nov 5, 2026 on each pharmacy's website, in U.S. dollars (converted when a pharmacy prices in Canadian dollars). The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Prices change often; confirm at checkout. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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Prices per g from 1 licensed pharmacy shipping to the U.S.: $13.26, any strength, before shipping.
Jump to: Medicare · Maker savings · Generic Opzelura · Similar drugs · Uses · FAQ
Opzelura (ruxolitinib) 1.5% cream for eczema and vitiligo in 60 g and 100 g tubes. No U.S. generic is sold, so compare brand prices and savings programs.
Cheapest ways to get Opzelura 100 g tube
The cheapest ways we found to get brand Opzelura 1.5% (prices checked Nov 5, 2026). The lowest price per unit is shaded green.
| Way to buy | Cost | Details |
|---|---|---|
| Licensed online pharmacy abroad | $13.26 per g | Brand Opzelura 1.5%, ships from Canada, not FDA-approved (made for another country). In a pack of 300 g for $3,979 (before shipping), checked Nov 5, 2026. See all prices |
| Maker’s patient assistance program | May be free if you qualify | IncyteCARES Patient Assistance Program, checked Oct 29, 2026. Who qualifies |
| Medicare Part D | Depends on your plan | Your plan’s drug list and coverage phase set your cost. Medicare costs |
Costs abroad and at U.S. pharmacies are the price per unit of one pack as sold, before shipping, from the price table above. Programs set their own rules, so check the terms before you count on one.
How much does Opzelura cost without insurance?
Without insurance, the U.S. list price is $2,136 for a 60 g tube, about $35.60 a gram (Incyte's 2026 price before discounts). Licensed pharmacies abroad charged from $13.26 per g for brand Opzelura in our latest check (Nov 5, 2026), before shipping; every offer we found abroad was for the 100 g tube. Incytecares: Opzelura at no cost for eligible patients with no prescription insurance (Incyte).
Opzelura cost with Medicare
In 2026, a Medicare drug plan (Part D) can charge a deductible of up to $615, and once you've spent $2,100 out of pocket on covered drugs, you pay nothing more for covered drugs that year ($2,400 in 2027) (Medicare.gov). What you pay for Opzelura depends on your plan's drug list and your coverage phase. If your income is limited, Extra Help lowers drug costs: in 2026 you pay no more than $5.10 for a generic and $12.65 for a brand-name drug, with income under $23,940 ($32,460 for a married couple) and resources under $18,090 ($36,100 for a couple) (CMS). The free Medicare Prescription Payment Plan spreads costs into monthly payments, but it doesn't lower the total.
| Medicare Part D | What Opzelura costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026 ($2,400 in 2027), you pay nothing more for covered drugs that year. | Medicare.gov |
Opzelura cost with insurance
With private or employer insurance, what you pay for Opzelura depends on your plan's drug list, deductible and copay. As little as $0 per tube with the Copay copay program if your plan covers Opzelura; $35 per prescription if it doesn't (not for Massachusetts patients whose plan doesn't cover it) (Incyte).
Medicaid: Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office (Medicaid.gov).
Opzelura patient assistance program
Yes. Opzelura is offered through IncyteCARES Patient Assistance Program, which can give the medicine at no cost to people who qualify. Who qualifies: Patients who are uninsured (no prescription insurance) or have Medicare Part D and can't afford Opzelura. Terms apply and can change. How to apply: For Jakafi, call IncyteCARES at 1-855-452-5234 or ask your prescriber to enroll you. For Opzelura, start at incytecares.com (Opzelura support page). (Checked 2026-10-29.)
Is there a generic Opzelura?
No. There is no generic Opzelura in the U.S. The FDA Orange Book lists only Incyte's Opzelura for ruxolitinib cream; no generic version has been approved.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 60 g tube | No | — | |
| 100 g tube | No | — |
Outside the U.S.: Opzelura is sold under the same name in Canada, the U.K. and Europe.
Source: FDA Orange Book: Opzelura (NDA 215309). As of Oct 26, 2026.
Opzelura FAQ
Why is Opzelura so expensive?
Opzelura is a brand-name medicine with no generic in the U.S., and Incyte sets its U.S. list price: $2,136 per 60 g tube (Incyte's 2026 price before discounts, as reported to the Texas Department of State Health Services). Incyte says the list price may not reflect what most people using Opzelura pay; with commercial insurance, the copay program may lower it to $0 per tube.
How much does Opzelura cost without insurance?
The U.S. list price is $2,136 for one 60 g tube, or $35.60 a gram (Incyte's 2026 price before discounts, as reported to the Texas Department of State Health Services). Incyte's cost page lists $2,094 per tube. Every offer we found abroad was for the 100 g tube: in our latest check (Nov 5, 2026), licensed pharmacies abroad charged from $13.26 per g for brand Opzelura, before shipping. People with no prescription insurance can apply to IncyteCARES, which may provide Opzelura at no cost to those who qualify.
How much does Opzelura cost with Medicare?
It depends on your Part D plan. In 2026, plans can have a deductible of up to $615, and out-of-pocket costs for covered drugs are capped at $2,100 a year ($2,400 in 2027). The copay program can't be used with Medicare, but IncyteCARES may help Part D patients who can't afford Opzelura, and Extra Help can lower costs for people with limited income.
Is there a generic Opzelura?
No. The FDA has not approved a generic ruxolitinib cream; the Orange Book lists only Incyte's Opzelura. The generic name is ruxolitinib.
Is Opzelura sold in Canada?
Yes. Health Canada approved Opzelura cream in October 2024, and it is sold there under the same name in 60 g and 100 g tubes. In Canada and Europe, the name Jakavi refers to ruxolitinib tablets, not the cream.
Is there a patient assistance program for Opzelura?
Yes. Opzelura is offered through IncyteCARES Patient Assistance Program, which can give the medicine at no cost to people who qualify. Who qualifies: Patients who are uninsured (no prescription insurance) or have Medicare Part D and can't afford Opzelura. Terms apply and can change. How to apply: For Jakafi, call IncyteCARES at 1-855-452-5234 or ask your prescriber to enroll you. For Opzelura, start at incytecares.com (Opzelura support page). (Checked 2026-10-29.)
How long does a tube of Opzelura last?
It depends on how much skin is treated. The label says adults and children 12 and older should not use more than one 60 g tube a week or one 100 g tube every 2 weeks. We compare prices per gram; your prescriber decides how much you use.
Is Opzelura the same as Jakafi?
No. Both contain ruxolitinib, but Jakafi is a tablet taken by mouth for blood disorders, and Opzelura is a cream for eczema and vitiligo. They are separate products and are not interchangeable.
Savings programs from the maker
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Opzelura coupons. These are the real savings programs, run by the drug's maker and by Medicare:
- Opzelura Copay Savings Card: for people with commercial (private or employer) insurance. If your plan covers Opzelura, you may pay as little as $0 per tube; if it doesn't, you pay $35 per prescription at participating pharmacies (not for Massachusetts patients whose plan doesn't cover it). Use no more than once every 25 days; yearly and per-tube maximums apply. Not for people who are uninsured or paying cash, or who have Medicare, Medicaid, TRICARE, VA or other government coverage. U.S. and Puerto Rico only. Call 833-613-2333. (program terms)
- IncyteCARES Patient Assistance Program (free medicine): Incyte may provide Opzelura at no cost to eligible patients who are uninsured or underinsured, including people with Medicare Part D who can't afford it. Terms and conditions apply and may change; contact IncyteCARES to check eligibility. (IncyteCARES)
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Compare Opzelura with similar drugs
Other JAK inhibitor medicines people compare with Opzelura: Rinvoq, a tablet used for atopic dermatitis and other conditions, and Jakafi, ruxolitinib tablets for blood disorders. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Rinvoqupadacitinib | Immune system medicine (JAK inhibitor) | From $6.40 per tablet | See prices |
| Jakafiruxolitinib | Kinase inhibitor (JAK inhibitor) for certain blood cancers and graft-versus-host disease | From $53.57 per tablet | See prices |
Lowest price per unit, before shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Opzelura used for?
Opzelura (ruxolitinib) is a JAK inhibitor cream. According to its FDA label (DailyMed), it is used for:
- Short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis (eczema) in people 2 years and older who are not immunocompromised, when other prescription skin treatments haven't worked well enough or aren't advisable.
- Nonsegmental vitiligo in people 12 years and older.
Opzelura is a 1.5% cream in 60 g and 100 g tubes, applied to the skin twice a day. The label says not to use more than one 60 g tube a week or one 100 g tube every 2 weeks (for children 2 to 11 with eczema, one 60 g tube every 2 weeks). It is not recommended with biologics, other JAK inhibitors or strong immunosuppressants. The label has a boxed warning about serious infections, death, cancer, major heart problems and blood clots, based partly on studies of JAK inhibitor pills. Your prescriber decides which medicine is right for you.
Is it safe to order Opzelura from Canada?
Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Opzelura is sold under the same name in 60 g and 100 g tubes. In the U.K. and Europe it is also sold as Opzelura, in 100 g tubes. Jakavi, sold in Canada and Europe, is the tablet form of ruxolitinib (Jakafi in the U.S.), not the cream.
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Sources
- Texas DSHS: 2026 annual WAC report (Opzelura 60 g tube (NDC 50881-007-05) $2,136.00)
- Incyte: Opzelura cost (WAC $2,094.00 per tube, checked 2026-10-26)
- Incyte: Opzelura Copay Savings Program terms (checked 2026-10-26)
- Incyte: Opzelura patient support and IncyteCARES (checked 2026-10-26)
- OPZELURA U.S. prescribing information (DailyMed) (version 14, June 2026)
- FDA Orange Book: Opzelura (NDA 215309) (EOBZIP_2026_09)
- Health Canada: Opzelura product monograph (authorized October 11, 2024; 60 g and 100 g tubes)
- European Medicines Agency: Opzelura authorised presentations (100 g tube)
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicaid.gov: cost sharing
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.