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Odefsey Cost, Coupons and Savings
- U.S. list price
- $12,074.94 for 90 days (90 tablets)The maker's price for brand Odefsey before discounts · Source: Texas DSHS 2026 WAC report
- Lowest international online pharmacy price
- $48.17 per tablet$4,349.95 for 90 days (90 tablets), shipping included · brand Odefsey 200 mg/25 mg/25 mg, not FDA-approved · ships from Australia
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Quick answerAs of Nov 11, 2026, brand Odefsey costs from $4,428.33 for 90 days at licensed pharmacies abroad we compared, vs. $12,074.94 at the U.S. list price ($4,024.98 for 30). With commercial insurance, Gilead's co-pay program covers up to $6,000 a year.
Compare Odefsey prices from licensed online pharmacies
For comparison U.S. pharmacy list price: $12,074.94 for 90 days ($134.17 per tablet), brand Odefsey before insurance. The prices below are from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per tabletOnline pharmacy A | ODEFSEY (EU pack, ships from Australia)200 mg/25 mg/25 mg · brand · Filled in AustraliaProduct of EU | $1,476.11per 30 tablets · 3 packs = $4,428.33$49.20 per tablet | FreeDelivery time not stated | $4,428.33 for 90 days= $4,428.33 for 90 daysSave 63%incl. $0 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy B | ODEFSEY200 mg/25 mg/25 mg · brand · Filled in AustraliaProduct of Australia | $1,478.50per 30 tablets · 3 packs = $4,435.50$49.28 per tablet | FreeDelivery time not stated | $4,435.50 for 90 days= $4,435.50 for 90 daysSave 63%incl. $0 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy CU.S. shipping limited | Odefsey (Emtricitabine/Rilpivirine/Tenofovir)200 mg/25 mg/25 mg · brand · Filled in AustraliaProduct of Australia | $4,335for 90 tablets$48.17 per tablet | $14.95Pharmacy's estimate: 8–14 business days | $4,349.95 for 90 days= $4,349.95 for 90 daysSave 64%incl. $14.95 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Odefsey from Canada?
90-day cost = 90 tablets at the usual dose of 1 a day, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price. The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout.
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Join to See PharmaciesAlready a member? Sign inOdefsey price by strength
| Strength | Lowest brand90 days | Price per tablet |
|---|---|---|
| Odefsey 200 mg/25 mg/25 mg | $4,428.33 | $49.20 |
Lowest 90-day cost with shipping at licensed pharmacies shipping to the U.S. now, counting only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price per tablet is for that lowest pack, before shipping. Prices checked Nov 11, 2026.
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90-day prices from 2 licensed pharmacies shipping to the U.S.: $4,428.33 to $4,435.50, any strength, shipping included.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Odefsey · Similar drugs · Uses · FAQ
Odefsey (emtricitabine, rilpivirine and tenofovir alafenamide) is a one-pill-a-day HIV treatment. No generic is sold in the U.S. yet.
Odefsey cost at a glance
- U.S. list price: $4,024.98 for a bottle of 30 tablets of brand Odefsey (the maker's wholesale price before discounts), about $134.17 a tablet (Texas DSHS).
- No generic on sale in the U.S. The FDA approved a generic from Apotex in January 2026, but the FDA lists it as discontinued and no generic version is listed as on the U.S. market (FDA Orange Book).
- How we count: 1 tablet a day. The label's dose is one tablet once a day with a meal, so 90 days is 90 tablets.
- From online pharmacies abroad: $4,428.33 to $4,435.50 for 90 days of brand Odefsey, shipping included (checked Nov 11, 2026). The U.S. list price for 90 tablets is $12,074.94.
- Savings: with private or employer insurance, Gilead's co-pay program covers up to $6,000 a year in out-of-pocket costs for Odefsey. People without insurance may be able to get it free from Gilead (Gilead Advancing Access).
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Odefsey cost in the U.S.?
| If you have | What Odefsey costs | Source |
|---|---|---|
| No insurance (list price) | $4,024.98 for 30 tablets of brand Odefsey, about $134.17 a tablet ($12,074.94 for 90 days). Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| No insurance (Gilead Advancing Access) | Gilead says people without insurance may be able to get their Gilead medicine free of charge. You must live in the U.S., Puerto Rico or a U.S. territory and meet other criteria. | Gilead Advancing Access |
| Private or employer insurance | Your copay depends on your plan's drug list. Gilead's co-pay program can cover up to $6,000 a year of your out-of-pocket costs for Odefsey. | Gilead Advancing Access |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Odefsey lists at $4,024.98 for 30 tablets, about $134.17 a tablet (Texas DSHS). This is the maker's wholesale price before discounts. No generic is on sale in the U.S., so most people pay through insurance, Medicare or a Gilead program. Insurance and help programs can bring what you pay far below the list price.
Odefsey cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for Odefsey depends on your plan's drug list.
| Medicare Part D | What Odefsey costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Odefsey coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
eDrugSearch does not offer its own Odefsey coupons. These programs can help with the cost of Odefsey:
- Gilead Advancing Access Co-pay Savings Program: for people with private or employer insurance. Covers up to $6,000 in out-of-pocket costs per calendar year for Odefsey, with no monthly limit. Not for Medicare, Medicaid, VA, TRICARE or other government-funded programs. Call 1-800-226-2056. (Co-pay program terms)
- Gilead Advancing Access patient assistance: if you don't have insurance, you may be able to get your Gilead medicine, including Odefsey, free of charge. You must live in the U.S., Puerto Rico or a U.S. territory and meet other criteria. Call 1-800-226-2056. (Gilead Advancing Access)
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Odefsey?
Not on sale. The FDA approved Apotex's generic emtricitabine, rilpivirine and tenofovir alafenamide tablets on January 30, 2026, rated equivalent to Odefsey. But the FDA lists that generic as discontinued, and its drug listings show only Gilead's brand on the U.S. market as of November 11, 2026.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 200/25/25 mg | No | — |
Outside the U.S.: Online pharmacies abroad may sell generic versions made for other markets. Those packs are not FDA-approved, and the price table labels them that way.
Source: FDA Orange Book: emtricitabine, rilpivirine and tenofovir alafenamide products. As of Nov 11, 2026.
Compare Odefsey with similar drugs
Other HIV medicines people often compare with Odefsey, including other one-pill regimens like Biktarvy, Genvoya and Juluca, and Edurant (rilpivirine alone). Your prescriber decides which medicine is right for you. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Biktarvybictegravir, emtricitabine and tenofovir alafenamide | HIV medicine (complete one-pill regimen: integrase inhibitor plus two NRTIs) | $502.77 for 90 days | See prices |
| Genvoyaelvitegravir, cobicistat, emtricitabine and tenofovir alafenamide | HIV medicine (complete one-tablet regimen) | $4,342.54 for 90 days | See prices |
| Julucadolutegravir and rilpivirine | HIV medicine (two-drug combination) | $3,699.95 for 90 days | See prices |
| Edurantrilpivirine | HIV medicine (NNRTI) | $1,049.05 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Odefsey used for?
Odefsey combines three HIV medicines in one tablet: emtricitabine and tenofovir alafenamide (nucleoside reverse transcriptase inhibitors) and rilpivirine (a non-nucleoside reverse transcriptase inhibitor). According to its FDA label (DailyMed), it is used:
- As a complete HIV-1 treatment for adults and children who weigh at least 25 kg (about 55 pounds) and have never taken HIV medicine, when their viral load is 100,000 copies/mL or lower.
- To replace a current HIV regimen in people whose virus has been fully under control for at least 6 months, with no history of treatment failure or known resistance to Odefsey's medicines.
Odefsey is one tablet taken once a day with a meal. The label says it must not be taken with certain other medicines, including some seizure medicines, rifampin, St. John's wort and stomach-acid medicines called proton pump inhibitors (such as omeprazole). Boxed warning: the label carries the FDA's strongest warning. In people who also have hepatitis B, stopping medicines like Odefsey can cause a severe flare of hepatitis B, so the label says liver tests should be watched closely for several months. Your prescriber decides which medicine is right for you.
Is it safe to order Odefsey from Canada?
Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Gilead sells Odefsey under the same name, in the same strength (Health Canada).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Odefsey without insurance?
The U.S. list price of brand Odefsey is $4,024.98 for 30 tablets, or $12,074.94 for 90 days (the maker's wholesale price before discounts). Licensed pharmacies abroad charged from $4,428.33 for 90 days of brand Odefsey in our latest check (Nov 11, 2026). People without insurance may be able to get it free through Gilead Advancing Access.
Is there a generic Odefsey?
Not on sale in the U.S. The FDA approved a generic from Apotex in January 2026, but the FDA lists it as discontinued, and only Gilead's brand is listed as on the market. Ask your pharmacist whether that has changed.
Is there an Odefsey coupon or co-pay card?
eDrugSearch doesn't offer coupons of its own. If you have private or employer insurance, Gilead's co-pay program covers up to $6,000 a year in out-of-pocket costs for Odefsey. It isn't for Medicare, Medicaid or other government plans.
How much does Odefsey cost with Medicare?
It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. People with limited income can apply for Extra Help, and the Medicare Prescription Payment Plan can spread costs over the year.
Is Odefsey the same as Complera?
No. Both contain emtricitabine and rilpivirine, but Odefsey uses tenofovir alafenamide and Complera uses tenofovir disoproxil fumarate. They are separate products with separate prices. Your prescriber decides which medicine is right for you.
What strength does Odefsey come in?
Odefsey comes in one strength: each tablet has 200 mg of emtricitabine, 25 mg of rilpivirine and 25 mg of tenofovir alafenamide. It's sold in the U.S. in bottles of 30.
Sources
- Texas DSHS: 2026 annual WAC report (Odefsey list price by NDC (61958210101, 30 tablets, $4,024.98))
- ODEFSEY U.S. prescribing information (DailyMed) (Gilead Sciences, label version 13, effective December 2, 2025)
- Drugs@FDA: Odefsey (NDA 208351) (approved March 1, 2016; Prescription, TE code AB)
- Drugs@FDA: Apotex generic (ANDA 214095) (approved January 30, 2026; marketing status Discontinued)
- FDA Orange Book: emtricitabine, rilpivirine and tenofovir alafenamide products
- FDA NDC Directory: rilpivirine products (no generic emtricitabine/rilpivirine/tenofovir alafenamide listed, checked November 11, 2026)
- Gilead Advancing Access: co-pay savings program (Odefsey up to $6,000 per calendar year, checked 2026-11-11)
- Gilead Advancing Access: patient assistance (checked 2026-11-11)
- Health Canada Drug Product Database: Odefsey (Gilead Sciences Canada; DIN 02461463, Marketed)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.