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Mayzent Price, Generic and Savings
- U.S. list price
- $29,962.26 for 90 days (90 tablets)The maker's price for brand Mayzent before discounts · Source: Texas DSHS 2026 WAC report
- Lowest international online pharmacy price
- $122.12 per tablet$11,007.11 for 90 days (90 tablets), shipping included · brand Mayzent 2 mg, not FDA-approved · ships from Australia
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Quick answerAs of Nov 12, 2026, brand Mayzent 2 mg costs from $11,007.11 for 90 days (90 tablets) at online pharmacies abroad we compared, vs. $29,962.26 at the U.S. list price ($9,987.42 for 30 tablets).
Name check: We price the 2 mg tablet, the usual daily dose after the start-up days. The 0.25 mg start-up tablets and the 1 mg tablet aren't priced here.
Compare Mayzent prices from licensed online pharmacies
For comparison U.S. pharmacy list price: $29,962.26 for 90 days ($332.91 per tablet), brand Mayzent before insurance. The prices below are from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per tabletOnline pharmacy A | Mayzent2 mg · brand · Filled in AustraliaMaker listed by pharmacy: Novartis | $3,419.45per 28 tablets · 3 packs = $10,258.35$122.12 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $10,273.30 for 84 days= $11,007.11 for 90 daysSave 63%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy B | MAYZENT (EU pack, ships from AUSTRALIA)2 mg · brand · Filled in AUSTRALIAProduct of EU | $3,435.63per 28 tablets · 3 packs = $10,306.89$122.70 per tablet | FreeDelivery time not stated | $10,306.89 for 84 days= $11,043.10 for 90 daysSave 63%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | MAYZENT (EU pack, ships from AUSTRALIA)2 mg · brand · Filled in AUSTRALIAProduct of EU | $3,438.02per 28 tablets · 3 packs = $10,314.06$122.79 per tablet | FreeDelivery time not stated | $10,314.06 for 84 days= $11,050.78 for 90 daysSave 63%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy D | MAYZENT 2MG TABLET 28 (BRAND FROM AUSTRALIA)2 mg · brand · Filled in AustraliaProduct of Australia | $3,570per 28 tablets · 3 packs = $10,710$127.50 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $10,724.95 for 84 days= $11,491.02 for 90 daysSave 62%Worked out from an 84-day orderChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Mayzent from Canada?
90-day cost = 90 tablets at the usual dose of 1 a day, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 12, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price. The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout.
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Join to See PharmaciesAlready a member? Sign inMayzent price by strength
| Strength | Lowest brand90 days | Price per tablet |
|---|---|---|
| Mayzent 2 mg | $11,007.11 | $122.12 |
Lowest 90-day cost with shipping at licensed pharmacies shipping to the U.S. now, counting only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price per tablet is for that lowest pack, before shipping. Prices checked Nov 12, 2026.
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90-day prices from 4 licensed pharmacies shipping to the U.S.: $11,007.11 to $11,491.02, any strength, shipping included.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Mayzent · Similar drugs · Uses · FAQ
Mayzent (siponimod) once-a-day tablets for relapsing multiple sclerosis. The FDA approved a generic siponimod in October 2026.
Mayzent cost at a glance
- U.S. list price: $9,987.42 for a bottle of 30 Mayzent 2 mg tablets, a 30-day supply, or $29,962.26 for 90 days. That's Novartis's wholesale price before discounts (Texas DSHS).
- A U.S. generic was just approved. The FDA approved Cipla's generic siponimod tablets on October 29, 2026, rated equivalent to Mayzent (Drugs@FDA). We found no list price for it in the 2026 Texas filing; ask your pharmacist whether it's in stock.
- How we count: 1 tablet a day. After a few start-up days on 0.25 mg tablets, the label's usual dose is 2 mg once a day (1 mg for people with certain CYP2C9 gene types), so 90 days is 90 tablets of 2 mg.
- From online pharmacies abroad: $11,007.11 to $11,491.02 for 90 days of brand Mayzent 2 mg, shipping included (checked Nov 12, 2026). Packs made for other countries are not FDA-approved.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Mayzent cost in the U.S.?
| If you have | What Mayzent costs | Source |
|---|---|---|
| No insurance (brand list price) | $9,987.42 for 30 tablets of Mayzent 2 mg. Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| No insurance (generic) | The FDA approved Cipla's generic siponimod on October 29, 2026. We found no 2026 list price for it; ask your pharmacist for the cash price. | Drugs@FDA |
| Private or employer insurance | Your copay depends on your plan's drug list. Ask your plan or pharmacist what you'd pay for brand Mayzent and for generic siponimod. | FDA Orange Book |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Mayzent 2 mg lists at $9,987.42 for a bottle of 30 tablets in the U.S. (Texas DSHS). That's the maker's wholesale price before discounts; what a pharmacy charges can differ.
Mayzent cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for Mayzent or generic siponimod depends on your plan's drug list.
| Medicare Part D | What Mayzent costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Mayzent coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
eDrugSearch does not offer its own Mayzent coupons. eDrugSearch has no coupons of its own. If you have Medicare, these two programs can help with the cost of Mayzent:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Mayzent?
Yes, newly. The FDA approved Cipla's generic siponimod tablets on October 29, 2026, rated equivalent to Mayzent. Two earlier approved generics are listed as discontinued.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 2 mg | Yes | Cipla | Oct 29, 2026 |
Outside the U.S.: Online pharmacies abroad may sell generic siponimod made for other markets. Those packs are not FDA-approved, and the price table labels them that way.
Source: Drugs@FDA: siponimod generics. As of Nov 14, 2026.
Compare Mayzent with similar drugs
Other multiple sclerosis medicines taken by mouth with price pages here: Gilenya works in a similar way, and Tecfidera, Vumerity and Aubagio work differently. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Gilenyafingolimod | Multiple sclerosis medicine (S1P receptor modulator) | $928.30 for 90 days | See prices |
| Tecfideradimethyl fumarate | Multiple sclerosis medicine (fumarate) | $732.26 for 90 days | See prices |
| Vumeritydiroximel fumarate | Multiple sclerosis medicine (fumarate) | Checking prices | See prices |
| Aubagioteriflunomide | Multiple sclerosis medicine (pyrimidine synthesis inhibitor) | $447.76 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Mayzent used for?
Mayzent (siponimod) is a sphingosine 1-phosphate (S1P) receptor modulator, a medicine that keeps some immune cells out of the brain and spinal cord. According to its FDA label (DailyMed), it is used:
- To treat relapsing forms of multiple sclerosis (MS) in adults, including clinically isolated syndrome, relapsing-remitting MS and active secondary progressive MS.
Before starting, the label calls for a CYP2C9 gene test, a blood count, an eye exam if needed, liver tests and a heart tracing (ECG). Treatment starts with a few days of slowly rising doses using 0.25 mg tablets, then 2 mg once a day (1 mg for people with CYP2C9*1/*3 or *2/*3 gene types). Tablets are swallowed whole. Your prescriber decides which medicine is right for you.
Is it safe to order Mayzent from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Mayzent, ask your pharmacist about the new U.S. generic and check your insurance first. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. Health Canada lists Mayzent 0.25 mg and 2 mg tablets from Novartis Canada as marketed (Health Canada Drug Product Database, checked 2026-11-14).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Mayzent without insurance?
The U.S. list price of brand Mayzent 2 mg is $9,987.42 for 30 tablets. Online pharmacies abroad charged from $11,007.11 for 90 days of brand Mayzent 2 mg in our latest check (Nov 12, 2026), shipping included.
Is there a generic Mayzent?
Yes, newly. The FDA approved Cipla's generic siponimod on October 29, 2026. It may take time to reach pharmacies, so ask your pharmacist.
Why only the 2 mg tablet?
2 mg once a day is the label's usual dose after the start-up days. The 0.25 mg tablets are mainly for starting treatment, so their prices aren't comparable here.
How much does Mayzent cost with Medicare?
It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. People with limited income can apply for Extra Help.
Can I buy Mayzent from Canada?
Mayzent is sold in Canada by Novartis. Federal law generally doesn't allow individuals to import prescription drugs, though the FDA has long used enforcement discretion for some personal-use shipments of up to a three-month supply. You need a prescription.
Sources
- Mayzent U.S. prescribing information (DailyMed) (Novartis label, version 17, effective 2026-06-30: relapsing MS in adults; titration then 2 mg daily (1 mg for CYP2C9*1/*3, *2/*3))
- Drugs@FDA: Mayzent (NDA 209884) (approved March 26, 2019; 0.25, 1 and 2 mg)
- Drugs@FDA: siponimod generics (Cipla ANDA218228 approved 2026-10-29, Prescription, AB; Riconpharma 2025-04-22 and Aurobindo 2026-03-06 Discontinued; Dr. Reddy's tentative)
- FDA NDC Directory: Mayzent (0078-0986 (2 mg, 30), Novartis, active; checked 2026-11-14)
- Texas DSHS 2026 WAC report: Mayzent (Novartis MAYZENT 00078098615 (30 x 2 mg) $9,987.42)
- Health Canada Drug Product Database: Mayzent (0.25 mg and 2 mg Marketed; 1 mg Approved)
- Texas DSHS: 2026 annual WAC report
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.