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Ibsrela Price (tenapanor)
- U.S. list price
- $6,132 for 90 days (180 tablets)The maker's price for brand Ibsrela before discounts · Source: Texas DSHS
- Lowest international online pharmacy price
- Not available
Quick answerAs of Nov 5, 2026, brand Ibsrela 50 mg costs from for 90 days at licensed pharmacies abroad we compared, vs. $6,132 at the U.S. list price ($2,044 for 60 tablets). With commercial insurance, Ardelyx's copay program says you may pay as little as $0.
Name check: Xphozah also contains tenapanor, but it is a separate product for high phosphate in dialysis, sold in other strengths. Its prices are not mixed in here.
Compare Ibsrela prices from licensed pharmacies
In our latest check, we found no licensed online pharmacy abroad selling this medicine.
Jump to: Medicare · Maker savings · Generic Ibsrela · Similar drugs · Uses · FAQ
Ibsrela (tenapanor) 50 mg tablets for IBS with constipation in adults. No generic is sold in the U.S., so compare brand prices and savings programs.
Cheapest ways to get Ibsrela 50 mg
The cheapest ways we found to get brand Ibsrela 50 mg (prices checked Nov 5, 2026). The lowest 90-day cost is shaded green.
| Way to buy | Cost | Details |
|---|---|---|
| U.S. list price | $6,132 for 90 days | Brand Ibsrela before insurance. Pharmacies may charge more. |
| Medicare Part D | Depends on your plan | Your plan’s drug list and coverage phase set your cost. Medicare costs |
Costs abroad and at U.S. pharmacies are for one order closest to 90 days, shipping included, from the price table above. Programs set their own rules, so check the terms before you count on one.
How much does Ibsrela cost without insurance?
Without insurance, Ibsrela costs $2,044 for a 30-day supply at the U.S. list price, or about $6,132 for 90 days.
Ibsrela cost with Medicare
In 2026, a Medicare drug plan (Part D) can charge a deductible of up to $615, and once you've spent $2,100 out of pocket on covered drugs, you pay nothing more for covered drugs that year ($2,400 in 2027) (Medicare.gov). What you pay for Ibsrela depends on your plan's drug list and your coverage phase. If your income is limited, Extra Help lowers drug costs: in 2026 you pay no more than $5.10 for a generic and $12.65 for a brand-name drug, with income under $23,940 ($32,460 for a married couple) and resources under $18,090 ($36,100 for a couple) (CMS). The free Medicare Prescription Payment Plan spreads costs into monthly payments, but it doesn't lower the total.
| Medicare Part D | What Ibsrela costs | Source |
|---|---|---|
| Part D deductible (2026) | Up to $615 a year, depending on your plan | Medicare.gov |
| Yearly out-of-pocket cap (2026) | $2,100 for covered Part D drugs ($2,400 in 2027) | Medicare.gov |
Ibsrela cost with insurance
With private or employer insurance, what you pay for Ibsrela depends on your plan's drug list, deductible and copay. As little as $0 per fill with the IBSRELA Copay Savings Program if your plan covers Ibsrela, up to a maximum set by the program (Ardelyx).
Medicaid: Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office (Medicaid.gov).
Ibsrela patient assistance program
Ardelyx runs ArdelyxAssist. Who qualifies: Ardelyx says patients facing coverage delays, insurance denials or out-of-pocket costs they can't afford may qualify for free medicine under one of its patient assistance programs. We couldn't confirm on the program's own pages that Ibsrela is on its current list (checked 2026-10-29), so call 1-844-427-7352 to ask before you apply.
Is there a generic Ibsrela?
No. No generic Ibsrela (tenapanor) is approved or sold in the U.S. The FDA Orange Book lists only Ardelyx's brand product.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 50 mg | No | — |
Outside the U.S.: We found no generic tenapanor sold abroad that we could confirm. Ibsrela is sold in Canada under the same name by Knight Therapeutics.
Source: FDA Orange Book: IBSRELA (NDA 211801). As of Oct 26, 2026.
Ibsrela FAQ
How much does Ibsrela cost with Medicare?
It depends on your Part D plan. In 2026, plans can have a deductible of up to $615, and out-of-pocket costs for covered Part D drugs are capped at $2,100 a year ($2,400 in 2027). The Ardelyx copay program can't be used with Medicare, but people with limited income can apply for Extra Help.
Is there a generic Ibsrela?
No. The FDA Orange Book lists no approved generic of Ibsrela (tenapanor), so only the brand from Ardelyx is sold in the U.S. The Orange Book lists patents on Ibsrela with expiration dates from 2029 to 2042.
Is Ibsrela sold in Canada?
Yes. Knight Therapeutics sells Ibsrela 50 mg in Canada under the same name (DIN 02498049). Health Canada's shortage site lists an anticipated supply interruption starting March 31, 2026, so availability at Canadian pharmacies may vary. Licensed pharmacies need a prescription from your doctor.
Does insurance cover Ibsrela?
It depends on your plan. Ardelyx says Ibsrela can be covered by Medicare, depending on your plan, and its copay program requires commercial insurance that covers Ibsrela. If your coverage is delayed or denied, Ardelyx says ArdelyxAssist (1-844-427-7352, Option 1) can help, and some patients may qualify for free medicine.
How much does Ibsrela cost without insurance?
Without insurance, Ibsrela costs $2,044 for a 30-day supply at the U.S. list price, or about $6,132 for 90 days.
Is there a patient assistance program for Ibsrela?
Ardelyx runs ArdelyxAssist. Who qualifies: Ardelyx says patients facing coverage delays, insurance denials or out-of-pocket costs they can't afford may qualify for free medicine under one of its patient assistance programs. We couldn't confirm on the program's own pages that Ibsrela is on its current list (checked 2026-10-29), so call 1-844-427-7352 to ask before you apply.
Is Xphozah the same as Ibsrela?
No. Both contain tenapanor and are made by Ardelyx, but Xphozah is a separate product in 10, 20 and 30 mg tablets, approved to lower blood phosphorus in adults with chronic kidney disease on dialysis. Ibsrela is a 50 mg tablet for IBS with constipation. Xphozah prices are not mixed in on this page.
Savings programs from the maker
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Ibsrela coupons. We found no Ardelyx cash-price program for Ibsrela in our latest check. These are the programs we could verify:
- IBSRELA Copay Savings Program: for people with private or commercial insurance that covers Ibsrela. You may pay as little as $0 per fill, and Ardelyx pays the rest up to a maximum set by the program. Not for Medicare, Medicaid or other government plans, and only for on-label use. Call 1-844-310-0790. (program terms)
- ArdelyxAssist: Ardelyx's patient support program. Ardelyx says patients facing coverage delays, insurance denials or out-of-pocket costs they can't afford may qualify for free medicine through one of its patient assistance programs. It does not publish income limits. Call 1-844-427-7352, Option 1. (Ardelyx patient support)
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Compare Ibsrela with similar drugs
Other prescription medicines people often compare with Ibsrela for IBS with constipation. Prices are for each drug's most common strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Linzesslinaclotide | Constipation and IBS-C medicine (guanylate cyclase-C agonist) | $317.52 for 90 days | See prices |
| Trulanceplecanatide | Constipation and IBS-C medicine (guanylate cyclase-C agonist) | $734.99 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Ibsrela used for?
Ibsrela (tenapanor) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor. According to its FDA label (DailyMed), it is used:
- To treat irritable bowel syndrome with constipation (IBS-C) in adults.
Ibsrela comes as 50 mg tablets in bottles of 60. The label's dose for adults is 50 mg twice a day, just before breakfast (or the first meal of the day) and just before dinner. The label has a boxed warning about serious dehydration in children: it must not be used in children under 6, should be avoided from age 6 to under 12, and has not been shown safe or effective under 18. Your prescriber decides which medicine is right for you.
Is it safe to order Ibsrela from Canada?
Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress declared in FD&C Act 804(j)(1), 21 U.S.C. 384(j)(1), that enforcement against individuals should focus on imports posing a significant threat to public health. You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Ibsrela is sold under the same name by Knight Therapeutics; Health Canada's shortage site lists an anticipated supply interruption starting March 31, 2026 (Drug Shortages Canada).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Sources
- Texas DSHS: 2026 Annual WAC Report (January 1, 2026 wholesale acquisition costs) (IBSRELA NDC 73154-0050-60 (60 tablets): $2,044.00; LINZESS 30 capsules $282.48; checked 2026-10-26)
- IBSRELA U.S. prescribing information (DailyMed) (label effective May 28, 2025)
- FDA Orange Book: IBSRELA (NDA 211801) (EOBZIP_2026_09)
- Ardelyx: IBSRELA Commercial Copay Program terms (US-IBS-0034v6 01/26)
- IBSRELA: Getting IBSRELA (savings and ArdelyxAssist)
- Ardelyx: treatment access and patient assistance
- Ardelyx: FDA approval of XPHOZAH (October 17, 2023)
- Drug Shortages Canada: IBSRELA (Knight Therapeutics) (anticipated shortage from 2026-03-31, checked 2026-10-26)
- Medicare.gov: costs in drug plans (2026 deductible up to $615; out-of-pocket cap $2,100 in 2026, $2,400 in 2027)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.