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Cuprimine Price, Generic and Savings
- Lowest price per capsule at U.S. online pharmacies
- $9.50 per capsuleIn a pack of 360 capsules for $3,420.80 (before shipping) · FDA-approved generic penicillamine 250 mg · ships within the U.S.
- Lowest price per capsule at online pharmacies abroad
- $4.34 per capsuleIn a pack of 300 capsules for $1,301.60 (before shipping) · brand Cuprimine 250 mg, not FDA-approved · ships from Canada
Generic penicillamine 250 mg (not FDA-approved · ships from MAURITIUS) from $0.63 per capsule
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Quick answerAs of Nov 12, 2026, brand Cuprimine 250 mg costs from $4.34 per capsule at online pharmacies abroad we compared, before shipping. In the U.S., brand Cuprimine lists at $26,188.64 for 100 capsules, about $261.89 each; generic penicillamine capsules list from $1,000.00 for 100.
Name check: This page covers Cuprimine capsules. Depen (penicillamine tablets) is a different product and isn't priced here.
Compare Cuprimine prices from licensed online pharmacies
| Pharmacy | Medication | Pack | Price per unit | Pack price | Shipping & delivery | Total with shipping | Buy |
|---|---|---|---|---|---|---|---|
| Lowest price per unitOnline pharmacy A | Penicillamine (India pack, ships from Mauritius)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in MauritiusProduct of India | 100 capsules1 other pack size
| $0.45 per capsule | $44.70 | Fee not publishedDelivery time not stated | $44.70+ shippingChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy B | Penicillamine (India pack, ships from Mauritius)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in MauritiusProduct of India | 100 capsules1 other pack size
| $0.56 per capsule | $55.99 | Fee not publishedDelivery time not stated | $55.99+ shippingChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy C | Generic penicillamine (the pharmacy lists it under Cuprimine) (India pack, ships from MAURITIUS)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in MAURITIUSProduct of India | 300 capsules2 other pack sizes
| $0.63 per capsule | $188.11 | FreeDelivery time not stated | $188.11Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | Generic penicillamine (the pharmacy lists it under Cuprimine) (India pack, ships from MAURITIUS)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in MAURITIUSProduct of India | 300 capsules2 other pack sizes
| $0.64 per capsule | $190.50 | FreeDelivery time not stated | $190.50Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | Penicillamine (India pack, ships from Mauritius)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in MauritiusProduct of India | 100 capsules1 other pack size
| $0.85 per capsule | $84.98 | $9.95Delivery time not stated | $94.93Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | PenicillamineNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Panacea | 90 capsules2 other pack sizes
| $0.92 per capsule | $82.96 | $14.95Pharmacy's estimate: 4–6 weeks | $97.91Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy C | PENICILLAMINENot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in INDIAMade for sale in INDIA.Product of India | 30 capsules | $0.97 per capsule | $28.95 | FreeDelivery time not stated | $28.95Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | PENICILLAMINENot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in INDIAMade for sale in INDIA.Product of India | 30 capsules | $1.07 per capsule | $32.17 | FreeDelivery time not stated | $32.17Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy G | Brand Cuprimine 250mg250 mg · brand · Filled in CanadaMaker listed by pharmacy: Bau | 300 capsules2 other pack sizes
| $4.34 per capsule | $1,301.60 | $14.95Pharmacy's estimate: 4–6 weeks | $1,316.55Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy A | Cuprimine250 mg · brand · Filled in CanadaProduct of Canada | 100 capsules | $4.78 per capsule | $477.71 | Fee not publishedDelivery time not stated | $477.71+ shippingChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy B | Cuprimine250 mg · brand · Filled in CanadaProduct of Canada | 100 capsules | $4.88 per capsule | $487.99 | Fee not publishedDelivery time not stated | $487.99+ shippingChecked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy C | CUPRIMINE250 mg · brand · Filled in CANADAMade for sale in CANADA.Product of Canada | 100 capsules | $7.58 per capsule | $757.96 | FreeDelivery time not stated | $757.96Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | CUPRIMINE250 mg · brand · Filled in CANADAMade for sale in CANADA.Product of Canada | 100 capsules | $7.60 per capsule | $760.35 | FreeDelivery time not stated | $760.35Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy H | Penicillamine 250mg Capsule250 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 12, 2026 | 360 capsules5 other pack sizes
| $9.50 per capsule | $3,420.80 | FreePharmacy's estimate: 3–5 business days | $3,420.80Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy IU.S. shipping limited | Penicillamine (Generic)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.250 mg · generic · Filled in IndiaMade for sale in India.Product of India | 100 capsules1 other pack size
| $1.11 per capsule | $111 | $14.95Pharmacy's estimate: 8–14 business days | $125.95Checked Nov 12 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Cuprimine from Canada?
Each row is one product from one pharmacy, shown in the pack size with the lowest price per unit; its other pack sizes are listed under “other pack sizes”. Price per unit = the pack price divided by the units in the pack, before shipping; we sort by it and don't assume how long a pack lasts. Total with shipping = the pack price plus the pharmacy's shipping fee for one order. Prices checked Nov 12, 2026 on each pharmacy's website, in U.S. dollars (converted when a pharmacy prices in Canadian dollars). The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, plus its standard shipping; no insurance or discount cards. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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Prices per capsule from 5 licensed pharmacies abroad shipping to the U.S.: $0.63 to $7.60, any strength, before shipping.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Cuprimine · Similar drugs · Uses · FAQ
Cuprimine (penicillamine) 250 mg capsules for Wilson's disease, cystinuria and severe rheumatoid arthritis. FDA-approved generics are sold in the U.S.
Cuprimine cost at a glance
- U.S. list price: $26,188.64 for a bottle of 100 brand Cuprimine 250 mg capsules, about $261.89 a capsule. That's Bausch Health's wholesale price before discounts (Texas DSHS).
- Generic Cuprimine is sold in the U.S., for much less. Several companies sell FDA-approved generic penicillamine 250 mg capsules, rated equivalent to Cuprimine (FDA Orange Book). In the 2026 filing, Par lists 100 capsules at $1,000.00 and Breckenridge at $1,080.00 (Texas DSHS).
- How we compare: per capsule. The dose depends on the condition and is adjusted over time, so we list each pharmacy's packs as sold and compare the price per capsule.
- From online pharmacies abroad: $4.34 to $7.60 per capsule of brand Cuprimine 250 mg, before shipping (checked Nov 12, 2026). Packs made for other countries are not FDA-approved.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Cuprimine cost in the U.S.?
| If you have | What Cuprimine costs | Source |
|---|---|---|
| No insurance (brand list price) | $26,188.64 for 100 capsules of Cuprimine 250 mg. Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| No insurance (generic) | Generic penicillamine 250 mg capsules list from $1,000.00 for 100 (Par); Breckenridge lists $1,080.00. Ask your pharmacist for the cash price. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan's drug list. Ask your plan or pharmacist what you'd pay for brand Cuprimine and for generic penicillamine. | FDA Orange Book |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Cuprimine lists at $26,188.64 for a bottle of 100 capsules in the U.S. (Texas DSHS). The same filing lists FDA-approved generic penicillamine capsules from $1,000.00 for 100. These are list prices; what a pharmacy charges can differ.
Cuprimine cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for Cuprimine or generic penicillamine depends on your plan's drug list.
| Medicare Part D | What Cuprimine costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Cuprimine coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
eDrugSearch does not offer its own Cuprimine coupons. eDrugSearch has no coupons of its own. If you have Medicare, these two programs can help with the cost of Cuprimine:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Cuprimine?
Yes. The FDA has approved generic penicillamine 250 mg capsules from several makers, rated equivalent to Cuprimine. The first was approved on May 7, 2019.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 250 mg | Yes | Teva (Watson), PH Health, Dr. Reddy's, Granules, InvaGen, Breckenridge, Navinta | May 7, 2019 |
Outside the U.S.: Online pharmacies abroad may sell generic penicillamine made for other markets. Those packs are not FDA-approved, and the price table labels them that way.
Source: Drugs@FDA: penicillamine generics. As of Nov 14, 2026.
Compare Cuprimine with similar drugs
Galzin (zinc acetate) is another Wilson's disease medicine with a price page here. It works differently. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Galzinzinc acetate | Wilson's disease medicine (zinc) | From $0.29 per capsule | See prices |
Lowest price per unit, before shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Cuprimine used for?
Cuprimine (penicillamine) is a chelating agent, a medicine that binds copper and the amino acid cystine so the body can pass them in urine. According to its FDA label (DailyMed), it is used:
- To treat Wilson's disease (a buildup of copper in the body).
- To treat cystinuria (a condition that causes cystine kidney stones).
- For severe, active rheumatoid arthritis that hasn't responded to usual treatment.
The label says to take Cuprimine on an empty stomach, at least 1 hour before or 2 hours after meals and apart from other medicines, food or milk. The dose depends on the condition: for cystinuria it's usually 2 g a day for adults (1 to 4 g); for rheumatoid arthritis it starts at 125 mg or 250 mg once a day and rises slowly; for Wilson's disease it's set from copper tests. Cuprimine has a boxed warning telling prescribers to know its risks well and to watch patients closely. Your prescriber decides which medicine is right for you.
Is it safe to order Cuprimine from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Cuprimine, compare the U.S. price of FDA-approved generic penicillamine before you order. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. Health Canada lists Cuprimine 250 mg capsules from Bausch Health Canada as marketed (Health Canada Drug Product Database, checked 2026-11-14).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Cuprimine without insurance?
The U.S. list price of brand Cuprimine is $26,188.64 for 100 capsules, about $261.89 each. Generic penicillamine capsules list from $1,000.00 for 100. Online pharmacies abroad charged from $4.34 per capsule for brand Cuprimine in our latest check (Nov 12, 2026), before shipping.
Is there a generic Cuprimine?
Yes. FDA-approved generic penicillamine 250 mg capsules have been FDA-approved since 2019, from several makers. Ask your pharmacist whether a generic can fill your prescription.
Is Depen the same as Cuprimine?
Both contain penicillamine, but Depen is a different product: a scored 250 mg tablet. This page covers Cuprimine capsules only.
How much does Cuprimine cost with Medicare?
It depends on your Part D plan's drug list. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year. People with limited income can apply for Extra Help.
Can I buy Cuprimine from Canada?
Cuprimine 250 mg capsules are sold in Canada by Bausch Health. Federal law generally doesn't allow individuals to import prescription drugs, though the FDA has long used enforcement discretion for some personal-use shipments of up to a three-month supply. You need a prescription.
Sources
- Cuprimine U.S. prescribing information (DailyMed) (Bausch Health label, version 17 (published 2026-01-28): Wilson's disease, cystinuria, severe active RA; empty stomach; cystinuria usual 2 g/day; RA starts 125 or 250 mg/day; boxed warning; bottles of 100)
- Drugs@FDA: Cuprimine (NDA 019853) (250 mg Prescription AB; 125 mg Discontinued)
- Drugs@FDA: penicillamine generics (capsules: ANI 2019-05-07 (discontinued); Watson 2019-06-24; PH Health 2019-12-23; Dr. Reddy's 2020-08-04; Granules 2020-12-02; InvaGen 2021-08-19; Breckenridge 2021-08-23; Navinta 2021-10-08)
- FDA Orange Book: penicillamine capsules
- FDA NDC Directory: Cuprimine (25010-705-15 (100 capsules), Bausch Health US, active; checked 2026-11-14)
- Texas DSHS 2026 WAC report: Cuprimine and generics (Bausch CUPRIMINE 25010070515 (100) $26,188.64; Par penicillamine 49884014601 (100) $1,000.00; Breckenridge 51991097401 (100) $1,080.00)
- Health Canada Drug Product Database: Cuprimine (DIN 00016055 (250 mg), Bausch Health Canada, Marketed; 125 mg cancelled)
- Texas DSHS: 2026 annual WAC report
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.