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Byetta (Exenatide) Cost and Generic Price
- Lowest U.S. online pharmacy price
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- Lowest international online pharmacy price
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Quick answerBrand Byetta is discontinued in the U.S. TrumpRx.gov lists FDA-approved generic exenatide 5 mcg at $630.90 per pen delivered (checked Nov 14, 2026); each pen lasts 30 days. We found no licensed pharmacy abroad that sells it.
Name check: Bydureon BCise (once-weekly exenatide) is a different product. Each Byetta or generic exenatide pen holds 60 doses: 30 days at 2 doses a day.
Byetta may cost less in the U.S.
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
Checking more than one medicine? Use the free Medicare Drug Cost Check.
These U.S. programs can cost less than ordering from abroad:
- TrumpRx.gov (generic exenatide): Generic exenatide (same pens as Byetta): $630.90 for a 5 mcg pen delivered, shipping included, lasting 30 days (checked Nov 14, 2026). 90 days (3 pens) is about $1,893. Pickup coupon prices vary by pharmacy and ZIP code. Your insurance isn't billed. $1,893 for 90 days (TrumpRx.gov)
We list these because they may save you money. No one pays us to include them. Prices and eligibility rules change, so confirm before you buy. Checked .
Compare Byetta prices from licensed online pharmacies
Ships cold: Byetta needs refrigerated shipping (36°F to 46°F, 2°C to 8°C) before first use, per its U.S. label. Check that the pharmacy ships it cold.
Source: U.S. prescribing information on DailyMed, checked Nov 14, 2026. Each price below says whether we confirmed cold shipping on the pharmacy's own shipping or FAQ page.
We are checking prices for this medication. Check back soon.
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Byetta (exenatide) twice-daily pen for type 2 diabetes: brand Byetta is discontinued in the U.S.; what generic exenatide costs and where its price comes from.
Byetta cost at a glance
- Brand Byetta is discontinued: Drugs@FDA lists both Byetta pens as discontinued, and FDA drug listings end their marketing on November 30, 2026 (10 mcg) and December 31, 2026 (5 mcg) (Drugs@FDA).
- Generic exenatide: TrumpRx.gov lists the 5 mcg pen at $630.90 delivered, shipping included, a 30-day supply, or about $1,893 for 90 days (checked Nov 14, 2026; TrumpRx.gov). Pickup coupon prices vary by pharmacy and ZIP code.
- Who makes it: Amneal's generic exenatide (approved November 19, 2024). Drugs@FDA now marks it discontinued too, and FDA drug listings show its marketing ending in May and June 2027, so ask your pharmacist about supply (FDA NDC Directory).
- Abroad: we found no licensed pharmacy abroad selling Byetta or exenatide pens. Health Canada lists Byetta as cancelled in Canada.
- How we count: pens. Each pen holds 60 doses, so one pen lasts 30 days at 2 doses a day, and 90 days is 3 pens.
How much does Byetta cost in the U.S.?
| If you have | What Byetta costs | Source |
|---|---|---|
| No insurance (generic) | $630.90 for a 5 mcg exenatide pen delivered (30 days; checked Nov 14, 2026) on TrumpRx.gov. Pickup coupon prices vary by pharmacy and ZIP code. | TrumpRx.gov |
| Private or employer insurance | Your copay depends on your plan's drug list. Ask your plan whether it covers generic exenatide. | Drugs@FDA (exenatide) |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Byetta is no longer made for the U.S. market, so it has no current list price we could confirm. Generic exenatide prices come from TrumpRx.gov and are cash prices at the pharmacies it lists.
Byetta cost with Medicare in 2026
Exenatide is approved for type 2 diabetes, so Medicare Part D plans may cover it; what you pay depends on your plan's drug list. In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered drugs reaches $2,100, you pay nothing more for covered drugs that year.
| Medicare Part D | What Byetta costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Byetta coupons and savings programs
eDrugSearch does not offer its own Byetta coupons. eDrugSearch has no coupons of its own. These programs can help:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Byetta?
Yes. The FDA approved Amneal's generic exenatide pens (5 mcg and 10 mcg, rated AP, equivalent to Byetta) on November 19, 2024. FDA drug listings show them on the market since November 22, 2024. Drugs@FDA now marks them discontinued, and their listings end in May and June 2027.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 5 mcg per dose (300 mcg/1.2 mL pen) | Yes | Amneal | Nov 22, 2024 |
| 10 mcg per dose (600 mcg/2.4 mL pen) | Yes | Amneal | Nov 22, 2024 |
Outside the U.S.: We found no licensed pharmacy abroad selling exenatide pens. Health Canada lists Byetta as cancelled (2022).
Source: Drugs@FDA: exenatide (ANDA 206697). As of Nov 14, 2026.
Compare Byetta with similar drugs
Other GLP-1 medicines for type 2 diabetes with price pages here: Victoza (liraglutide, daily; generic available), Ozempic (semaglutide, weekly), Trulicity (dulaglutide, weekly) and Mounjaro (tirzepatide, weekly).
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Victozaliraglutide | Type 2 diabetes medicine (GLP-1 receptor agonist), once-daily injection | $779.99 for 90 days | See prices |
| Ozempicsemaglutide | Diabetes medicine (GLP-1 receptor agonist), once-weekly injection | $642.78 for 90 days | See prices |
| Trulicitydulaglutide | Diabetes medicine, once-weekly injection (GLP-1 receptor agonist) | From $71.24 per pen | See prices |
| Mounjarotirzepatide | Type 2 diabetes medicine (GIP and GLP-1 receptor agonist), once-weekly injection | $1,607.07 for 90 days | See prices |
Lowest price from licensed pharmacies shipping to the U.S., any strength: 90-day prices include shipping; prices per unit are before shipping. Only your doctor can decide whether another drug is right for you.
What is Byetta used for?
Byetta (exenatide) is a twice-daily GLP-1 injection. According to its FDA label (DailyMed), it is used:
- With diet and exercise to improve blood sugar control in adults with type 2 diabetes.
The label says to start at 5 mcg twice a day, within 60 minutes before the morning and evening meals, and the dose can go up to 10 mcg twice a day after one month. Each pen holds 60 doses and is thrown away 30 days after first use. Unused pens are kept in the refrigerator. The label says using it with other exenatide products is not recommended. Your prescriber decides which medicine is right for you.
Is it safe to order Byetta from Canada?
Many Americans do, but U.S. law and customs rules apply. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. Byetta isn't sold in Canada anymore: Health Canada lists both Byetta pens as cancelled (Health Canada Drug Product Database, checked 2026-11-14), and we found no licensed pharmacy abroad that sells exenatide pens.
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
Is Byetta discontinued?
Yes, in the U.S. Drugs@FDA lists Byetta as discontinued, and its FDA drug listings end on November 30, 2026 (10 mcg) and December 31, 2026 (5 mcg). Amneal's generic exenatide pens are also marked discontinued at Drugs@FDA, with FDA drug listings ending in May and June 2027, so ask your pharmacist about supply.
How much does generic Byetta cost?
TrumpRx.gov lists generic exenatide 5 mcg at $630.90 per pen delivered, shipping included (checked Nov 14, 2026); pickup coupon prices vary by pharmacy and ZIP code. Each pen lasts 30 days at 2 doses a day.
How long does a Byetta pen last?
Each pen has 60 doses, which is 30 days at 2 doses a day. The label says to throw the pen away 30 days after first use even if some medicine is left.
Can I buy Byetta from Canada?
No. Health Canada lists Byetta as cancelled, and we found no licensed pharmacy abroad selling exenatide pens.
Is Bydureon the same as Byetta?
Both contain exenatide, but Bydureon BCise is a once-weekly extended-release injection and Byetta is taken twice a day. They are different products.
Sources
- Byetta U.S. prescribing information (DailyMed) (AstraZeneca label version 26, effective 2025-09-02: 5/10 mcg twice daily, 60-dose pens, storage)
- Drugs@FDA: Byetta (NDA 021773) (both pens Discontinued (checked 2026-11-14))
- FDA NDC Directory: exenatide (Byetta 0310-6512 end 2026-12-31, 0310-6524 end 2026-11-30; Amneal 70121-1685 end 2027-06-30, 70121-1686 end 2027-05-31)
- Exenatide (Amneal) label (DailyMed) (ANDA 206697, version 17, effective 2026-05-27)
- Drugs@FDA: exenatide (ANDA 206697) (approved 2024-11-19, rated AP; marketing status Discontinued (checked 2026-11-14))
- TrumpRx.gov: exenatide (5 mcg pen $630.90 delivered, shipping included (independent review read, 2026-11-14); pickup coupon prices vary by pharmacy/ZIP; 10 mcg not confirmed)
- Health Canada Drug Product Database: Byetta (DINs 02361809 and 02361817, Cancelled Post Market (2022))
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.