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Zofran Price and Generic Ondansetron
- Lowest price per tablet at U.S. online pharmacies
- Not available
- Lowest price per tablet at online pharmacies abroad
- $2.42 per tabletIn a pack of 90 tablets for $217.70 (before shipping) · brand Zofran 8 mg, not FDA-approved · ships from Australia
FDA-approved generic ondansetron 8 mg from $0.28 per tablet at U.S. pharmacies
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Quick answerAs of Nov 11, 2026, brand Zofran 8 mg costs from $2.42 per tablet at licensed pharmacies abroad we compared, before shipping. Brand Zofran is no longer sold in the U.S. FDA-approved generic ondansetron is, with U.S. list prices from $5.50 for 30 tablets (8 mg).
Name check: Zofran ODT (sold as Zofran Zydis in Australia), Zofran oral solution and Zofran injection are other forms. Only Zofran tablets you swallow are priced here.
Compare Zofran prices from licensed online pharmacies
| Pharmacy | Medication | Pack | Price per unit | Pack price | Shipping & delivery | Total with shipping | Buy |
|---|---|---|---|---|---|---|---|
| Lowest price per unitLicensed U.S. pharmacy A | Ondansetron HCL 8mg Tablet (Wholesale Price List, 90-day supply)8 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 90 tablets | $0.28 per tablet | $25 | FreePharmacy's estimate: 3–5 business days | $25Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy B | OndansetronNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in New ZealandProduct of New Zealand | 100 tablets1 other pack size
| $0.36 per tablet | $35.99 | Fee not publishedDelivery time not stated | $35.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy B | OndansetronNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in New ZealandProduct of New Zealand | 100 tablets1 other pack size
| $0.39 per tablet | $38.99 | Fee not publishedDelivery time not stated | $38.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy C | Ondansetron 8 mg Tablets8 mg · genericMaker listed by pharmacy: Rising Pharma Holdings, Inc.Ships from United StatesShips within the U.S. (no customs) · checked Nov 4, 2026 | 90 tablets4 other pack sizes
| $0.46 per tablet | $41.40 | $5Pharmacy's estimate: 2–8 business days | $46.40Checked Nov 4 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy A | Ondansetron HCL 8mg Tablet (Wholesale Price List, 30-day supply)8 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | 30 tablets | $0.50 per tablet | $15 | FreePharmacy's estimate: 3–5 business days | $15Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | Ondansetron 4mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Cipla Ltd | 90 tablets2 other pack sizes
| $0.62 per tablet | $55.38 | $14.95Pharmacy's estimate: 4–6 weeks | $70.33Checked Nov 4 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | ONDANSETRONNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in IndiaMade for sale in India.Product of India | 30 tablets | $0.66 per tablet | $19.66 | FreeDelivery time not stated | $19.66Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed U.S. pharmacy C | Ondansetron 4 mg Tablets4 mg · genericMaker listed by pharmacy: Aurobindo Pharma LimitedShips from United StatesShips within the U.S. (no customs) · checked Nov 4, 2026 | 30 tablets4 other pack sizes
| $0.68 per tablet | $20.40 | $5Pharmacy's estimate: 2–8 business days | $25.40Checked Nov 4 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | Ondansetron 8mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: Cipla Ltd | 90 tablets2 other pack sizes
| $0.69 per tablet | $62.17 | $14.95Pharmacy's estimate: 4–6 weeks | $77.12Checked Nov 4 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | ZOFRAN 4MG TABLET 90 (GENERIC ONDANSETRON FROM INDIA)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: CIPLA | 90 tablets | $0.74 per tablet | $67 | $14.95Pharmacy's estimate: 4–6 weeks | $81.95Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | ONDANSETRONNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in IndiaMade for sale in India.Product of India | 30 tablets | $0.84 per tablet | $25.32 | FreeDelivery time not stated | $25.32Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | Ondansetron 4mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in New ZealandMaker listed by pharmacy: Dr. Reddy's Laboratories | 100 tablets4 other pack sizes
| $0.85 per tablet | $85.15 | $14.95Pharmacy's estimate: 4–6 weeks | $100.10Checked Nov 4 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | ZOFRAN 8MG TABLET 90 (GENERIC ONDANSETRON FROM INDIA)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in IndiaMade for sale in India.Maker listed by pharmacy: CIPLA | 90 tablets | $0.89 per tablet | $80 | $14.95Pharmacy's estimate: 4–6 weeks | $94.95Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed online pharmacy G | Zofran 4mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in New ZealandProduct of New Zealand | 100 tablets | $0.91 per tablet | $91 | FreeDelivery time not stated | $91Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | ZOFRAN (India pack, ships from Mauritius)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in MauritiusProduct of India | 100 tablets | $0.93 per tablet | $93.45 | FreeDelivery time not stated | $93.45Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed online pharmacy G | Zofran odt 4mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in New ZealandProduct of New Zealand | 100 tablets | $0.98 per tablet | $98 | FreeDelivery time not stated | $98Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | ZOFRAN (India pack, ships from Mauritius)Not FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in MauritiusProduct of India | 100 tablets | $1.07 per tablet | $107.05 | FreeDelivery time not stated | $107.05Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed online pharmacy G | Zofran 8mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in New ZealandProduct of New Zealand | 50 tablets | $1.26 per tablet | $63 | FreeDelivery time not stated | $63Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy H | Zofran 8mg Tablet8 mg · brand · Filled in AustraliaMaker listed by pharmacy: Maker not shown by pharmacy | 90 tablets3 other pack sizes
| $1.70 per tablet | $152.62 | Fee not publishedDelivery time not stated | $152.62+ shippingChecked Nov 5 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy B | Zofran8 mg · brand · Filled in AustraliaProduct of Australia | 90 tablets3 other pack sizes
| $1.80 per tablet | $161.99 | Fee not publishedDelivery time not stated | $161.99+ shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy I | Brand Zofran 8mg8 mg · brand · Filled in AustraliaMaker listed by pharmacy: Aspen | 90 tablets1 other pack size
| $2.42 per tablet | $217.70 | $14.95Pharmacy's estimate: 4–6 weeks | $232.65Checked Nov 4 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy D | Zofran 8mg8 mg · brand · Filled in AustraliaMaker listed by pharmacy: Aspen | 90 tablets1 other pack size
| $2.42 per tablet | $217.74 | $14.95Pharmacy's estimate: 4–6 weeks | $232.69Checked Nov 4 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy J | Brand Zofran 8mg8 mg · brand · Filled in AustraliaMaker listed by pharmacy: Aspen | 90 tablets1 other pack size
| $2.52 per tablet | $227.10 | $14.95Pharmacy's estimate: 4–6 weeks | $242.05Checked Nov 4 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy K | Ondansetron 4mg TabletNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in CanadaMaker listed by pharmacy: Natco | 100 tablets3 other pack sizes
| $2.61 per tablet | $260.94 | FreePharmacy's estimate: 2–3 weeks | $260.94Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy L | Brand Zofran 8mg8 mg · brand · Filled in AustraliaMaker listed by pharmacy: Aspen | 90 tablets1 other pack size
| $2.65 per tablet | $238.06 | $14.95Pharmacy's estimate: 4–6 weeks | $253.01Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy E | ZOFRAN (EU pack, ships from Australia)8 mg · brand · Filled in AustraliaProduct of EU | 90 tablets1 other pack size
| $2.67 per tablet | $240.07 | FreeDelivery time not stated | $240.07Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy F | ZOFRAN 8MG TABLET 90 (BRAND FROM AUSTRALIA)8 mg · brand · Filled in AustraliaMaker listed by pharmacy: ASPEN PHARMACARE | 90 tablets | $2.99 per tablet | $268.75 | $14.95Pharmacy's estimate: 4–6 weeks | $283.70Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy M | Ondansetron 4mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in CanadaMaker listed by pharmacy: Jamp Pharma Corp. | 10 tablets2 other pack sizes
| $3.00 per tablet | $30 | $9.95Pharmacy's estimate: 4–6 weeks | $39.95Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy M | Ondansetron 8mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in CanadaMaker listed by pharmacy: Jamp Pharma Corp. | 30 tablets2 other pack sizes
| $3.60 per tablet | $108 | $9.95Pharmacy's estimate: 4–6 weeks | $117.95Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy K | Ondansetron 8mg TabletNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in CanadaMaker listed by pharmacy: Natco | 100 tablets3 other pack sizes
| $3.73 per tablet | $373.29 | FreePharmacy's estimate: 2–3 weeks | $373.29Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed Canadian pharmacy N | Ondansetron 4mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.4 mg · generic · Filled in CanadaMaker listed by pharmacy: Natco Pharma Ltd. | 100 tablets3 other pack sizes
| $4.32 per tablet | $432.10 | $9.95Pharmacy's estimate: 3–6 weeks | $442.05Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed online pharmacy G | Zofran odt 4mg4 mg · brand · Filled in AustraliaProduct of Australia | 30 tablets | $6.13 per tablet | $184 | FreeDelivery time not stated | $184Checked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitLicensed Canadian pharmacy N | Ondansetron 8mgNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in CanadaMaker listed by pharmacy: Natco Pharma Ltd. | 100 tablets3 other pack sizes
| $6.32 per tablet | $631.60 | $9.95Pharmacy's estimate: 3–6 weeks | $641.55Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
| Lowest price per unitOnline pharmacy K | Ondansetron 8mg TabletNot FDA-approvedMade for sale in another country. It has the same active ingredient as the brand, but the FDA hasn't reviewed this maker's version.8 mg · generic · Filled in New ZealandMaker listed by pharmacy: Dr Reddy's Labs | 30 tablets2 other pack sizes
| $12.95 per tablet | $388.50 | FreePharmacy's estimate: 2–3 weeks | $388.50Checked Nov 3 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Zofran from Canada?
| Strength | Lowest brandper unit, before shipping | Lowest generic abroadper unit, not FDA-approved |
|---|---|---|
| Zofran 4 mg | $6.13 per tablet | $0.62 per tablet |
| Zofran 8 mg | $2.42 per tablet | $0.69 per tablet |
Each row is one product from one pharmacy, shown in the pack size with the lowest price per unit; its other pack sizes are listed under “other pack sizes”. Price per unit = the pack price divided by the units in the pack, before shipping; we sort by it and don't assume how long a pack lasts. Total with shipping = the pack price plus the pharmacy's shipping fee for one order. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars (converted when a pharmacy prices in Canadian dollars). The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, plus its standard shipping; no insurance or discount cards. “Fee not published” means the pharmacy doesn’t show its shipping fee before checkout, so that row’s total is the medicine price only.
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Prices per tablet from 10 licensed pharmacies abroad shipping to the U.S.: $0.62 to $12.95, any strength, before shipping.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Zofran · Uses · FAQ
Zofran (ondansetron) helps prevent nausea and vomiting from chemotherapy, radiation or surgery. The brand isn't sold in the U.S. anymore, but generics are.
Zofran cost at a glance
- Brand Zofran is no longer sold in the U.S. The FDA lists every Zofran tablet, Zofran ODT and Zofran oral solution as discontinued, and it has determined they were not taken off the market for safety or effectiveness reasons (Drugs@FDA).
- Generic Zofran is sold in the U.S. FDA-approved generic ondansetron tablets, ODT and oral solution come from many companies. In the 2026 Texas drug price filing, 30-tablet bottles of generic ondansetron list from $4.45 for 4 mg and $5.50 for 8 mg (both Rising) (Texas DSHS). List prices are the maker's wholesale price before discounts; ask your pharmacist for the cash price.
- How we compare: we list each pharmacy's packs as sold and compare the price per tablet. Zofran is taken in short courses around chemotherapy, radiation or surgery, so there's no single daily dose. Your prescription says how many you need.
- With Medicare: Part B covers anti-nausea pills taken before, during or within 48 hours of chemotherapy, or as a full replacement for an IV anti-nausea drug. You usually pay up to 20% after the Part B deductible (Medicare.gov). Otherwise your Part D plan sets the cost.
- From online pharmacies abroad: $2.42 to $2.99 per tablet for brand Zofran 8 mg, before shipping (checked Nov 11, 2026). In the U.S., generic ondansetron 8 mg list prices start at $5.50 for 30 tablets.
How much does Zofran cost in the U.S.?
| If you have | What Zofran costs | Source |
|---|---|---|
| No insurance (brand Zofran) | Brand Zofran is no longer sold in the U.S., so there is no U.S. brand list price. The FDA lists all Zofran tablets, ODT and oral solution as discontinued. | Drugs@FDA |
| No insurance (generic ondansetron) | FDA-approved generic ondansetron is sold in the U.S. List prices for 30 tablets of generic ondansetron 8 mg range from $5.50 (Rising) to $209.17 (Chartwell RX) in the 2026 Texas filing. Ask your pharmacist for the cash price. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan. Ask your plan how it covers generic ondansetron. | Drugs@FDA |
| Medicare Part B (with chemotherapy) | Part B covers anti-nausea pills taken before, during or within 48 hours of chemotherapy, or as a full replacement for an IV anti-nausea drug. You usually pay up to 20% of the Medicare-approved amount after the Part B deductible. | Medicare.gov |
| Medicare Part D | For other uses, your Part D plan sets the cost. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Zofran tablets were first approved in the U.S. in 1992. Sandoz held the U.S. approvals, and the FDA now lists every Zofran tablet, ODT and oral solution as discontinued (Drugs@FDA). U.S. prescriptions are filled with FDA-approved generic ondansetron.
Zofran cost with Medicare in 2026
Medicare Part B covers anti-nausea pills like ondansetron when you take them before, during or within 48 hours of chemotherapy for cancer, or as a full replacement for an IV anti-nausea drug. For other uses, your Part D plan sets the cost. In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year.
| Medicare Part D | What Zofran costs | Source |
|---|---|---|
| Part B (with chemotherapy) | Medicare covers anti-nausea drugs you take by mouth before, during or within 48 hours of chemotherapy for cancer, or as a full replacement for an IV anti-nausea drug. You usually pay up to 20% after the Part B deductible. | Medicare.gov |
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Zofran coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Zofran coupons. These Medicare programs can help with the cost of generic ondansetron:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Zofran?
Yes. The FDA has approved generic ondansetron tablets (4 and 8 mg), orally disintegrating tablets (4 and 8 mg) and oral solution (4 mg/5 mL) from many companies, rated equivalent to Zofran. The first generic tablets were approved on December 26, 2006 (Dr. Reddy's). Brand Zofran itself is no longer sold in the U.S.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 4 mg | Yes | Tablets: Dr. Reddy's, Glenmark, Natco, Aurobindo, Chartwell, Ipca. ODT: Sun, Sandoz, Glenmark, Aurobindo, Chartwell, Ipca | — |
| 8 mg | Yes | Tablets: Dr. Reddy's, Glenmark, Natco, Aurobindo, Chartwell, Ipca. ODT: Sun, Sandoz, Glenmark, Aurobindo, Chartwell, Ipca | — |
Outside the U.S.: Online pharmacies abroad may also sell generic ondansetron made for other markets. Those packs are not FDA-approved, and the price table labels them that way.
Source: FDA Orange Book: ondansetron products. As of Nov 5, 2026.
What is Zofran used for?
Zofran (ondansetron) is a 5-HT3 receptor blocker, a type of anti-nausea medicine. No Zofran-brand label is posted on DailyMed now, so these uses come from the FDA label of a generic ondansetron that matches Zofran (DailyMed). It is used to help prevent:
- Nausea and vomiting from highly emetogenic cancer chemotherapy (chemotherapy very likely to cause vomiting), including cisplatin.
- Nausea and vomiting from first and repeat courses of moderately emetogenic cancer chemotherapy.
- Nausea and vomiting from radiation therapy to the whole body or to the abdomen.
- Nausea and vomiting after surgery.
Ondansetron comes as 4 mg and 8 mg tablets, 4 mg and 8 mg orally disintegrating tablets (ODT) and an oral solution (4 mg in 5 mL). The label says matching doses of the three forms may be used interchangeably. It has no boxed warning. The label warns about heart rhythm changes (QT prolongation) and serotonin syndrome, mainly with other serotonin-raising medicines. Your prescriber decides which medicine is right for you.
Is it safe to order Zofran from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Zofran, compare the U.S. price of FDA-approved generic ondansetron before you order. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Australia, Zofran tablets and Zofran Zydis (the melt-in-the-mouth form) are sold under the Zofran name (PBS).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Zofran without insurance?
Brand Zofran is no longer sold in the U.S., so there is no U.S. brand list price. Licensed pharmacies abroad charged from $2.42 per tablet for brand Zofran 8 mg in our latest check (Nov 11, 2026), before shipping. In the U.S., list prices for 30 tablets of FDA-approved generic ondansetron start at $4.45 (4 mg) and $5.50 (8 mg), both from Rising, in the 2026 Texas filing; ask your pharmacist for the cash price.
Is Zofran discontinued in the U.S.?
Yes. The FDA lists every brand Zofran tablet, Zofran ODT and Zofran oral solution as discontinued. The FDA has determined they were not taken off the market for safety or effectiveness reasons. U.S. pharmacies fill Zofran prescriptions with FDA-approved generic ondansetron.
Is there a generic Zofran?
Yes. The generic name is ondansetron. The FDA has approved generic ondansetron tablets, orally disintegrating tablets and oral solution from many companies, rated equivalent to Zofran. The first generic tablets were approved in December 2006. Ask your pharmacist whether a generic can fill your prescription.
How much does ondansetron cost?
It depends on the maker. In the 2026 Texas drug price filing, 30-tablet bottles of generic ondansetron 8 mg list at $5.50 (Rising), $15.96 (Dr. Reddy's) and $209.17 (Chartwell RX). These are list prices before discounts, so what a pharmacy charges can differ. Ask your pharmacist for the cash price.
Why is my Zofran prescription so expensive?
Prices for generic ondansetron differ a lot by maker and pharmacy. In the 2026 Texas filing, list prices for 30 tablets of ondansetron 8 mg run from $5.50 (Rising) to $209.17 (Chartwell RX). Ask your pharmacist which maker they stock and what the cash price is. Insurance and Medicare rules can also change what you pay.
Is there a Zofran coupon or savings card?
eDrugSearch doesn't offer coupons of its own. If you have Medicare and limited income, Extra Help can lower what you pay for generic ondansetron, and Medicare's Prescription Payment Plan can spread drug costs over the year. Ask your pharmacist for the cash price of generic ondansetron.
How much does Zofran cost with Medicare?
Medicare Part B covers anti-nausea pills taken before, during or within 48 hours of chemotherapy, or as a full replacement for an IV anti-nausea drug; you usually pay up to 20% after the Part B deductible. For other uses, it depends on your Part D plan. In 2026, Part D deductibles are capped at $615 and out-of-pocket costs for covered drugs at $2,100 a year.
What is the difference between Zofran and Zofran ODT?
Both contain ondansetron. Zofran is a tablet you swallow. Zofran ODT is an orally disintegrating tablet that melts on the tongue; in Australia it's sold as Zofran Zydis. The FDA label says matching doses of the tablets, ODT and oral solution may be used interchangeably. Only Zofran tablets are priced on this page. Your prescriber decides which form is right for you.
Sources
- Drugs@FDA: Zofran tablets (NDA 020103) (Discontinued; not withdrawn for safety or effectiveness reasons, checked 2026-11-05)
- Drugs@FDA: Zofran ODT (NDA 020781) (Discontinued, checked 2026-11-05)
- Drugs@FDA: Zofran oral solution (NDA 020605) (Discontinued, checked 2026-11-05)
- FDA Orange Book: ondansetron products (generic tablets, ODT and oral solution rated equivalent)
- FDA NDC Directory: Dr. Reddy's ondansetron tablets (marketing start December 26, 2006)
- Texas DSHS 2026 annual WAC report (generic ondansetron list prices (Jan. 1, 2026))
- Ondansetron tablets U.S. prescribing information (DailyMed) (generic label (Chartwell RX, ANDA 077303); no Zofran-brand label is posted)
- Medicare.gov: Part B outpatient prescription drugs (oral anti-nausea drugs with chemotherapy, checked 2026-11-05)
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Australian PBS: ondansetron listings (Zofran tablets and Zofran Zydis wafers listed, checked 2026-11-05)
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.