Generic Xifaxan (rifaximin) Price

Rifaximin price by strength

Rifaximin names

- Brand name: Xifaxan (Salix Pharmaceuticals (Bausch Health))
- Generic name: rifaximin

Rifaximin packs made for other countries are not FDA-approved.

Rifaximin FAQ

Brand vs. generic: cost for 90 days

Lowest in this comparison: Brand Xifaxan 550 mg from licensed pharmacies abroad.

90 days = 180 tablets of 550 mg. Generic sold abroad is not FDA-approved and is not in this box. Your price with insurance or Medicare depends on your plan.

See brand Xifaxan prices

Rifaximin cost with Medicare in 2026

Each Part D plan has its own list of covered drugs and copays (Medicare Plan Finder). No FDA-approved generic rifaximin is sold in the U.S. yet. Check how your plan covers brand Xifaxan; the Xifaxan page has Medicare details. In 2026, Part D plans can have a yearly deductible of up to $615, and your out-of-pocket costs for covered drugs are capped at $2,100 a year ($2,400 in 2027) (Medicare.gov).

Savings programs from the maker

eDrugSearch does not offer its own Rifaximin coupons. Maker savings and assistance programs are for brand Xifaxan only, not generic rifaximin from abroad (see the Xifaxan page). eDrugSearch has no coupons of its own. These programs can lower prescription costs if you have Medicare:

• Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
• Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)

When people choose brand Xifaxan

Some people get brand Xifaxan instead of generic rifaximin. Common reasons:

• In the U.S., rifaximin is sold only as brand Xifaxan. The Xifaxan page shows U.S. prices, prices abroad and the maker's savings programs.
• Some insurance and Medicare drug plans cover brand Xifaxan. Your plan's drug list shows whether it does and what you pay.

Your prescriber decides which medicine is right for you.

Compare prices for your other medicines

• Xifaxan prices from $75.40 for 90 days

Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength.

What is Rifaximin used for?

Rifaximin is the active ingredient in Xifaxan. Xifaxan (rifaximin) is an antibiotic that works mainly in the gut. According to its FDA label (DailyMed), it is used to:

• Lower the risk of overt hepatic encephalopathy (HE) coming back in adults. HE is confusion and other brain changes caused by serious liver disease.
• Treat irritable bowel syndrome with diarrhea (IBS-D) in adults.
• Treat travelers' diarrhea caused by certain E. coli bacteria in adults and children 12 and older. It should not be used when diarrhea comes with fever or blood in the stool.

Xifaxan comes as 200 mg and 550 mg tablets. The FDA label lists different schedules for each use: 550 mg two times a day for HE (ongoing), 550 mg three times a day for 14 days for IBS-D (a course that can be repeated up to two times if symptoms come back), and 200 mg three times a day for 3 days for travelers' diarrhea. That is why our 90-day cost uses 2 tablets of 550 mg a day, and why an IBS-D course costs less. Your prescriber decides which medicine is right for you.