Epclusa Price (sofosbuvir and velpatasvir)

Epclusa price by strength

Cheapest ways to get Epclusa 400/100 mg

The cheapest ways we found to get brand Epclusa 400/100 mg (prices checked Nov 11, 2026). The lowest course cost is shaded green.

Costs abroad and at U.S. pharmacies are for one order closest to 90 days, shipping included, from the price table above. Programs set their own rules, so check the terms before you count on one.

How much does Epclusa cost without insurance?

Without insurance, Epclusa costs $24,920 for a 30-day supply at the U.S. list price, or about $74,760 for one 12-week course. Licensed pharmacies abroad charged from $72,253.76 for one 12-week course of brand Epclusa 400/100 mg in our latest check (Nov 11, 2026), shipping included. Support path: Gilead offers assistance for uninsured and underinsured people, and free medicine for qualified patients who meet program criteria. Call 1-855-769-7284 (Gilead).

Epclusa cost with Medicare

In 2026, a Medicare drug plan (Part D) can charge a deductible of up to $615, and once you've spent $2,100 out of pocket on covered drugs, you pay nothing more for covered drugs that year ($2,400 in 2027) (Medicare.gov). What you pay for Epclusa depends on your plan's drug list and your coverage phase. If your income is limited, Extra Help lowers drug costs: in 2026 you pay no more than $5.10 for a generic and $12.65 for a brand-name drug, with income under $23,940 ($32,460 for a married couple) and resources under $18,090 ($36,100 for a couple) (CMS). The free Medicare Prescription Payment Plan spreads costs into monthly payments, but it doesn't lower the total.

Epclusa cost with insurance

With private or employer insurance, what you pay for Epclusa depends on your plan's drug list, deductible and copay. As little as $5 per co-pay with the Epclusa co-pay offer, up to 25% of the catalog price for three bottles, for 6 months after first use (Gilead).

Medicaid: Gilead says most people with Medicaid coverage pay $0 for the full course of treatment (based on Gilead's 2025 data). Ask your pharmacist or state Medicaid office (Gilead).

Epclusa patient assistance program

Gilead Sciences runs Gilead Advancing Access Patient Assistance Program. Who qualifies: People without health insurance who live in the U.S., Puerto Rico or a U.S. territory and meet other program criteria. We couldn't confirm on the program's own pages that Epclusa is on its current list (checked 2026-10-29), so call 1-800-226-2056 to ask before you apply.

Epclusa FAQ

Savings programs from the maker

eDrugSearch does not offer its own Epclusa coupons. eDrugSearch has no coupons of its own. These are the Epclusa savings programs we could verify on Gilead's and the government's own sites:

• Epclusa co-pay coupon (Gilead Support Path): for people with commercial or private insurance. Eligible patients could pay as little as $5 per co-pay. Help is capped at 25% of the catalog price for three bottles and lasts 6 months from first use, with no monthly limit. Not for Medicare, Medicaid, TRICARE, VA or other government programs, and not for uninsured or cash-paying patients. Call 1-855-769-7284. (coupon terms)
• Gilead Support Path (patient assistance): Gilead's hepatitis C support program helps people check their coverage and offers assistance for the uninsured and underinsured. Gilead's patient assistance program provides medicine at no cost to qualified patients who meet its criteria. Call 1-855-769-7284. (Gilead U.S. patient access)
• Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
• Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)

Compare Epclusa with similar drugs

Mavyret is another all-genotype hepatitis C medicine people often compare with Epclusa. Prices are for each drug's lowest-priced strength. Your prescriber decides which medicine is right for you.

Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.

What is Epclusa used for?

Epclusa (sofosbuvir and velpatasvir) combines two hepatitis C antivirals: sofosbuvir, an NS5B polymerase inhibitor, and velpatasvir, an NS5A inhibitor. According to its FDA label (prescribing information), it is used for chronic hepatitis C virus (HCV) infection, genotypes 1 to 6, in adults and children 3 years and older:

• Without cirrhosis or with compensated cirrhosis (Child-Pugh A).
• With decompensated cirrhosis (Child-Pugh B or C), together with ribavirin.

Adults take one 400/100 mg tablet once a day, with or without food. The label lists a 12-week course for each group above, including liver transplant recipients without cirrhosis or with compensated cirrhosis. Children 3 years and older take a dose based on weight, using the 200/50 mg tablet or oral pellets (200/50 mg and 150/37.5 mg packets); this page compares tablet prices. Boxed warning: hepatitis B can flare up again (reactivate) in people who have both hepatitis C and hepatitis B, in some cases causing severe liver problems, liver failure and death. The label says everyone should be tested for hepatitis B before starting. The Epclusa and ribavirin combination is not for people who can't take ribavirin. Your prescriber decides which medicine is right for you.