Entresto Price (sacubitril and valsartan)

Entresto price by strength

Cheapest ways to get Entresto 24/26 mg

The cheapest ways we found to get brand Entresto 24/26 mg (prices checked Nov 11, 2026). The lowest 90-day cost is shaded green.

Costs abroad and at U.S. pharmacies are for one order closest to 90 days, shipping included, from the price table above. Programs set their own rules, so check the terms before you count on one.

How much does Entresto cost without insurance?

Without insurance, Entresto costs $705.21 for a 30-day supply at the U.S. list price, or about $2,115.63 for 90 days. Licensed pharmacies abroad charged from $187.02 for 90 days of brand Entresto 24/26 mg in our latest check (Nov 11, 2026), shipping included. U.S. generic: FDA-approved generic sacubitril and valsartan is sold in the U.S. Their U.S. list prices start at $52 for 60 tablets (Macleods) and go up to $619.21 (AvKARE), depending on the maker and strength (the makers' prices before discounts). Ask your pharmacist for the cash price (Texas DSHS 2026 WAC report).

Entresto cost with Medicare

In 2026, a Medicare drug plan (Part D) can charge a deductible of up to $615, and once you've spent $2,100 out of pocket on covered drugs, you pay nothing more for covered drugs that year ($2,400 in 2027) (Medicare.gov). What you pay for Entresto depends on your plan's drug list and your coverage phase. Since January 1, 2026, Medicare pays a negotiated price of $295 for a 30-day supply of Entresto (CMS, checked 2026-10-29). That's what Medicare pays, not your copay. If your income is limited, Extra Help lowers drug costs: in 2026 you pay no more than $5.10 for a generic and $12.65 for a brand-name drug, with income under $23,940 ($32,460 for a married couple) and resources under $18,090 ($36,100 for a couple) (CMS). The free Medicare Prescription Payment Plan spreads costs into monthly payments, but it doesn't lower the total.

Entresto cost with insurance

With private or employer insurance, what you pay for Entresto depends on your plan's drug list, deductible and copay. Your copay depends on your plan. Novartis says eligible patients may pay as little as $10 for up to a 90-day supply of brand Entresto with its co-pay offer (Novartis).

Medicaid: Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office (Medicaid.gov).

Entresto patient assistance program

Novartis runs Novartis Patient Assistance Foundation (NPAF). Who qualifies: People in the U.S. or a U.S. territory, treated as outpatients by a U.S. provider, who are uninsured or have government insurance and meet income guidelines. We couldn't confirm on the program's own pages that Entresto is on its current list (checked 2026-10-29), so call 1-800-277-2254 to ask before you apply.

Entresto FAQ

Brand vs. generic: cost for 90 days

Lowest in this comparison: Brand Entresto 24/26 mg from licensed pharmacies abroad.

90 days = 180 tablets of 24/26 mg. Generic sold abroad is not FDA-approved and is not in this box. Your price with insurance or Medicare depends on your plan.

Savings programs from the maker

eDrugSearch does not offer its own Entresto coupons. Entresto is not on the Novartis Patient Assistance Foundation's list of supported medicines (checked 2026-10-26). These are the programs we could find:

• Entresto Co-Pay Offer (Novartis): Novartis says eligible patients may pay as little as $10 for up to a 90-day supply of brand Entresto. Eligibility depends on your insurance, and limits apply; offers like this generally can't be used with Medicare, Medicaid or other government plans. Call 1-888-368-7378 (1-888-ENTRESTO). (Novartis)
• Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
• Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
• Costco Pharmacy member prices: Costco publishes member prices for many prescriptions, for people with a Costco membership. Non-members can also use Costco pharmacies and pay the regular cash price. Member prices can't be used with insurance, Medicare or Medicaid claims. (Costco Pharmacy)
• Amazon Pharmacy Prime and RxPass: Amazon Pharmacy offers Prime members discounts on many prescriptions, and RxPass, for Prime members, covers a set list of generics for a flat monthly fee. Prime is not required to use Amazon Pharmacy. Prime savings have limits for people with Medicare, Medicaid or Tricare, and RxPass is not open to people with Medicaid or CHIP. (Amazon Pharmacy)
• Discount cards: Discount cards (for example GoodRx or SingleCare) may lower the price at local pharmacies; prices vary by pharmacy and ZIP code.

Compare Entresto with similar drugs

Other medicines with heart failure uses that people often compare with Entresto. They work differently, and your prescriber decides which medicine is right for you. Prices are for each drug's lowest-priced strength.

Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.

What is Entresto used for?

Entresto combines sacubitril, a neprilysin inhibitor, with valsartan, an angiotensin II receptor blocker (ARB). According to its FDA label (DailyMed), it is used:

• To lower the risk of death from heart and blood vessel causes and of hospital stays for heart failure in adults with chronic heart failure. The label says the benefit is clearest when the heart's pumping strength (ejection fraction) is below normal.
• To treat symptomatic heart failure caused by weak pumping of the main heart chamber (systemic left ventricular systolic dysfunction) in children 1 year and older.

Entresto comes as 24/26 mg, 49/51 mg and 97/103 mg tablets taken twice a day; Entresto Sprinkle comes as oral pellets in capsules (6/6 mg and 15/16 mg) for children. The label has a boxed warning: drugs like Entresto that act on the renin-angiotensin system can injure or cause the death of an unborn baby, and the label tells prescribers to discontinue Entresto as soon as possible when pregnancy is detected. The label says Entresto must not be used together with an ACE inhibitor. Your prescriber decides which medicine is right for you.