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Calquence Cost, Copay Card and Savings
- U.S. list price
- $48,912.09 for 90 days (180 tablets)The maker's price for brand Calquence before discounts · Source: Texas DSHS 2026 WAC report
- Lowest international online pharmacy price
- $187.06 per tablet$33,686.85 for 90 days (180 tablets), shipping included · brand Calquence 100 mg, not FDA-approved · ships from Australia
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Quick answerAs of Nov 11, 2026, brand Calquence 100 mg costs from $33,686.85 for 90 days at licensed pharmacies abroad we compared, vs. $48,912.09 at the U.S. list price ($16,304.03 for 60 tablets). With commercial insurance, AstraZeneca's savings program may lower a fill to $0.
Compare Calquence prices from licensed online pharmacies
For comparison U.S. pharmacy list price: $48,912.09 for 90 days ($271.73 per tablet), brand Calquence before insurance. The prices below are from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per tabletOnline pharmacy A | Calquence (capsules; U.S. Calquence is sold as tablets and capsules)100 mg · brand · Filled in AustraliaMaker listed by pharmacy: AstraZeneca | $10,475.37per 56 tablets · 3 packs = $31,426.11$187.06 per tablet | $14.95Pharmacy's estimate: 4–6 weeks | $31,441.06 for 84 days= $33,686.85 for 90 daysSave 31%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy B | Calquence (Acalabrutinib) (capsules; U.S. Calquence is sold as tablets and capsules)100 mg · brand · Filled in AustraliaMaker listed by pharmacy: Astra-Zeneca | $11,569.44per 56 tablets · 3 packs = $34,708.32$206.60 per tablet | FreePharmacy's estimate: 2–3 weeks | $34,708.32 for 84 days= $37,187.49 for 90 daysSave 24%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy C | CALQUENCE (EU pack, ships from Australia)100 mg · brand · Filled in AustraliaProduct of EU | $11,982.52per 56 tablets · 3 packs = $35,947.56$213.97 per tablet | FreeDelivery time not stated | $35,947.56 for 84 days= $38,515.24 for 90 daysSave 21%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per tabletOnline pharmacy D | CALQUENCE100 mg · brand · Filled in AustraliaProduct of Australia | $11,984.91per 56 tablets · 3 packs = $35,954.73$214.02 per tablet | FreeDelivery time not stated | $35,954.73 for 84 days= $38,522.93 for 90 daysSave 21%Worked out from an 84-day orderChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Calquence from Canada?
90-day cost = 180 tablets at the usual dose of 2 a day, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price. The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout.
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Join to See PharmaciesAlready a member? Sign inCalquence price by strength
| Strength | Lowest brand90 days | Price per tablet |
|---|---|---|
| Calquence 100 mg | $33,686.85 | $187.06 |
Lowest 90-day cost with shipping at licensed pharmacies shipping to the U.S. now, counting only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price per tablet is for that lowest pack, before shipping. Prices checked Nov 11, 2026.
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90-day prices from 4 licensed pharmacies shipping to the U.S.: $33,686.85 to $38,522.93, any strength, shipping included.
Jump to: U.S. cost · Medicare · Coupons & savings · Generic Calquence · Similar drugs · Uses · FAQ
Calquence (acalabrutinib) treats chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma and mantle cell lymphoma. No generic is sold in the U.S.
Calquence cost at a glance
- U.S. list price: a bottle of 60 Calquence 100 mg tablets, a 30-day supply, lists at $16,304.03 (the maker's wholesale price before discounts) (Texas DSHS).
- No generic Calquence in the U.S. The FDA lists no generic acalabrutinib, and the Orange Book lists patents on Calquence that run into 2036 (FDA Orange Book).
- AstraZeneca savings program: with commercial insurance, you may pay as little as $0 per 30-day supply; limits may apply. Not for Medicare, Medicaid or other government plans (program terms).
- How we count: 2 tablets a day. The label's dose is 100 mg about every 12 hours, so 90 days is 180 tablets.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
- From online pharmacies abroad: $33,686.85 to $38,522.93 for 90 days (180 tablets) of brand Calquence 100 mg, shipping included (checked Nov 11, 2026). The U.S. list price for 180 tablets is $48,912.09.
How much does Calquence cost in the U.S.?
| If you have | What Calquence costs | Source |
|---|---|---|
| No insurance (list price) | Calquence 100 mg, 60 tablets (30 days): $16,304.03. Pharmacies may charge more. AstraZeneca's AZ&Me program lists Calquence for eligible people without insurance. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan. The CALQUENCE Patient Savings Program may lower it to as little as $0 per 30-day supply; limits may apply. | AstraZeneca |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. The savings program can't be used with Medicare; AZ&Me lists a program for people with Medicare. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Calquence is sold in the U.S. by AstraZeneca in bottles of 60 tablets, a 30-day supply at the label's dose. The 2026 list price is $16,304.03 a bottle, about $271.73 a tablet (Texas DSHS). No FDA-approved generic is sold in the U.S. List prices are what makers charge wholesalers; what you pay depends on your coverage.
Calquence cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. Calquence is also one of 15 drugs with a Medicare negotiated price starting January 1, 2027: $8,600 for a 30-day supply, 40% below its 2024 list price (CMS). What you pay depends on your plan's drug list.
| Medicare Part D | What Calquence costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Calquence coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Calquence coupons. eDrugSearch has no coupons of its own. These programs can help with the cost of Calquence:
- CALQUENCE Patient Savings Program (AstraZeneca): for people 18 and older with commercial (private) insurance. Eligible patients may pay as little as $0 per 30-day supply; monthly, yearly or per-claim limits may apply. Not for anyone whose prescription is paid in part or in full by Medicare Part B or D, Medicaid, Medigap, VA, DoD, TRICARE or other government programs. Call AstraZeneca Access 360 at 1-844-275-2360. (Program terms)
- AZ&Me Prescription Savings Program (AstraZeneca): AstraZeneca's patient assistance program lists Calquence for people without insurance and for people with Medicare who meet its income and other criteria. (RxAssist listing)
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Calquence?
No. No generic Calquence is sold in the U.S. The FDA Orange Book lists only AstraZeneca's Calquence capsules (NDA 210259, approved October 31, 2017) and tablets (NDA 216387, approved August 3, 2022), with patents listed into 2036.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 100 mg | No | — |
Outside the U.S.: Online pharmacies abroad may sell generic acalabrutinib made for other markets. Those packs are not FDA-approved, and the price table labels them that way.
Source: FDA Orange Book: acalabrutinib products. As of Nov 11, 2026.
Compare Calquence with similar drugs
Imbruvica (ibrutinib) is another BTK inhibitor used for CLL and other blood cancers. Your prescriber decides which medicine is right for you. Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Imbruvicaibrutinib | Blood cancer medicine (BTK inhibitor) | $1,085.93 for 90 days | See prices |
Lowest 90-day price including shipping, from licensed pharmacies shipping to the U.S., any strength. Only your doctor can decide whether another drug is right for you.
What is Calquence used for?
Calquence (acalabrutinib) is a BTK inhibitor. It blocks a protein that some blood cancer cells need to grow and survive. According to its FDA label (DailyMed), it is used in adults:
- To treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
- To treat mantle cell lymphoma (MCL) after at least one earlier treatment.
- With bendamustine and rituximab, to treat newly diagnosed mantle cell lymphoma in people who can't have a stem cell transplant.
Calquence comes as 100 mg tablets and 100 mg capsules, taken about every 12 hours, swallowed whole with water, with or without food. The label warns about serious infections, bleeding, low blood counts, other cancers including skin cancer, heart rhythm problems and liver injury. Your prescriber decides which medicine is right for you.
Is it safe to order Calquence from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Calquence, check what your U.S. coverage and the savings programs would cost you first before you order. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. In Canada, Calquence 100 mg tablets are sold under the same name by AstraZeneca Canada; the capsules are listed as dormant (Health Canada).
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Calquence without insurance?
The U.S. list price is $16,304.03 for 60 tablets of 100 mg, a 30-day supply, in the Texas 2026 drug price filing. Licensed pharmacies abroad charged from $33,686.85 for 90 days (180 tablets) of brand Calquence in our latest check (Nov 11, 2026). AstraZeneca's AZ&Me program lists Calquence for eligible people without insurance.
Is there a Calquence copay card?
Yes, for people with commercial insurance. With the CALQUENCE Patient Savings Program, eligible patients may pay as little as $0 per 30-day supply; limits may apply. It can't be used if Medicare, Medicaid, TRICARE, VA or another government program pays any part of the prescription. Call 1-844-275-2360.
Is there a generic for Calquence?
No. The FDA lists no generic acalabrutinib, and the Orange Book lists patents on Calquence running into 2036. Some pharmacies abroad sell generic acalabrutinib made for other countries; those packs are not FDA-approved.
How much does Calquence cost with Medicare?
It depends on your Part D plan. In 2026, out-of-pocket costs for covered drugs are capped at $2,100 a year, and Part D deductibles at $615. The copay card can't be used with Medicare, but AstraZeneca's AZ&Me program lists a program for people with Medicare. Starting January 1, 2027, Medicare's negotiated price for Calquence is $8,600 for a 30-day supply.
How many Calquence tablets do I need a month?
At the label's dose of 100 mg about every 12 hours, you take 2 tablets a day, or 60 tablets for 30 days. That's why a U.S. bottle holds 60 tablets.
Can I buy Calquence from Canada?
Calquence 100 mg tablets are sold in Canada by AstraZeneca Canada. Packs made for Canada are not FDA-approved, and U.S. import rules apply. The price table shows where each pack comes from.
Sources
- Texas DSHS: 2026 annual WAC report (Calquence 100 mg tablets x60 $16,304.03 (AstraZeneca, NDC 0310-3512-60))
- CALQUENCE tablets U.S. prescribing information (DailyMed) (AstraZeneca, label version 9 (effective February 19, 2026))
- FDA Orange Book: acalabrutinib products (Calquence capsules NDA 210259 and tablets NDA 216387 (AstraZeneca); no generics; listed patents to July 1, 2036)
- Drugs@FDA: Calquence tablets (NDA 216387) (approved August 3, 2022; capsules NDA 210259 approved October 31, 2017)
- CALQUENCE Patient Savings Program enrollment and terms (as little as $0 per 30-day supply; commercial insurance; government programs excluded; checked 2026-11-11)
- RxAssist: AstraZeneca programs (Calquence listed under Access 360, AZ&Me for people with Medicare and AZ&Me for people without insurance; checked 2026-11-11)
- CMS: negotiated prices for 2027 (fact sheet, November 2025) (Calquence: $14,228 list price (2024) vs. $8,600 negotiated price per 30-day supply, 40% lower, effective January 1, 2027)
- Health Canada Drug Product Database: Calquence (tablet DIN 02535696: marketed; capsule DIN 02491788: dormant; checked 2026-11-11)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.