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Apriso Cost, Generic and Savings
- Lowest U.S. online pharmacy price
- $4.30 per capsule$1,553 for 90 days (360 capsules), shipping included · FDA-approved brand Apriso 375 mg · ships within the U.S.
- Lowest international online pharmacy price
- Not available
FDA-approved generic mesalamine 375 mg from $401.34 for 90 days at U.S. pharmacies
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Quick answerBrand Apriso lists at $510.31 for 120 capsules (30 days) in the U.S. As of Nov 11, 2026, U.S. pharmacies we compared charged from $1,553 for 90 days of brand Apriso and from $401.34 for the generic. We found no Apriso offers abroad that met our listing rules.
Name check: Lialda, Asacol HD, Pentasa and mesalamine suppositories or enemas are different mesalamine products with their own doses, and aren't priced on this page.
Compare Apriso prices from licensed online pharmacies
For comparison U.S. pharmacy list price: $1,530.93 for 90 days ($4.25 per capsule), brand Apriso before insurance. The prices below are from U.S. pharmacies that publish cash prices and from licensed online pharmacies outside the U.S.
| Pharmacy | Medication | Price | Shipping & delivery | Total (90 days) | Buy |
|---|---|---|---|---|---|
| Lowest per capsuleLicensed U.S. pharmacy A | Mesalamine ER 375mg375 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $133.78per 120 capsules · 3 packs = $401.34$1.11 per capsule | FreePharmacy's estimate: 3–5 business days | $401.34 for 90 days= $401.34 for 90 daysSave 74%incl. $0 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per capsuleLicensed U.S. pharmacy B | Mesalamine CP 0.375gm Capsules375 mg · genericU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $35.70per 30 capsules · 12 packs = $428.40$1.19 per capsule | $5Pharmacy's estimate: 2–8 business days | $433.40 for 90 days= $433.40 for 90 daysSave 72%incl. $5 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
| Lowest per capsuleLicensed U.S. pharmacy B | Apriso ER 0.375gm Capsules375 mg · brandU.S. pharmacy; maker not listed on its price pageShips from United StatesShips within the U.S. (no customs) · checked Nov 11, 2026 | $258per 60 capsules · 6 packs = $1,548$4.30 per capsule | $5Pharmacy's estimate: 2–8 business days | $1,553 for 90 days= $1,553 for 90 daysincl. $5 shippingChecked Nov 11 | See pharmacy (members) Members see the pharmacy |
No prices match those filters.
Buying from a pharmacy outside the U.S.? Read Is it safe to order Apriso from Canada?
90-day cost = 360 capsules at the usual dose of 4 a day, bought as one order of whole packs with one shipping fee. 90-day cost is worked out from each pharmacy's real order size so different pack sizes compare fairly. Orders are kept within a 3-month supply (92 days); a pack that is larger than that is marked and not used for the lowest price at the top of this page. Prices checked Nov 11, 2026 on each pharmacy's website, in U.S. dollars. Savings compare with the U.S. list price. The lowest price at the top of this page uses only packs whose maker the pharmacy names, or whose product country and ships-from country it states. Price is the pharmacy's own price for one pack, as shown on its website (converted to U.S. dollars when it prices in Canadian dollars). Delivery is the pharmacy's own estimate for the shipping option shown, not a promise; some pharmacies count from when they receive your prescription or ship the order. Total = the packs needed + shipping. When those packs don't add up to exactly 90 days, the row shows what that order costs and, under it, what it works out to for 90 days; we sort by the 90-day amount so pack sizes compare fairly. Prices change often; confirm at checkout. U.S. rows: the cash price a U.S. pharmacy published on its own website on the date shown, for whole fills, plus its standard shipping; no insurance or discount cards.
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Jump to: U.S. cost · Medicare · Coupons & savings · Generic Apriso · Similar drugs · Uses · FAQ
Apriso (mesalamine) 0.375 g extended-release capsules to help keep ulcerative colitis in remission. FDA-approved generics are sold in the U.S.
Apriso cost at a glance
- Generic Apriso is sold in the U.S. The FDA has approved generic mesalamine 0.375 g extended-release capsules from Mylan, Zydus, Alkem, Alembic, Aurobindo and others, rated equivalent to Apriso (FDA Orange Book). Teva also sells an authorized generic made under the Apriso approval.
- U.S. list price: $510.31 for a bottle of 120 brand Apriso capsules, a 30-day supply at the label dose. That's $1,530.93 for 90 days. Generic bottles of 120 list from $98 (Ascend) to $440.42 (Mylan) (the makers' wholesale prices before discounts; Texas DSHS).
- How we count: 4 capsules a day, because the label dose is 1.5 g (four 0.375 g capsules) once a day in the morning. So 90 days is 360 capsules.
- From pharmacies we compared: $1,553 for 90 days of brand Apriso from a U.S. pharmacy, and from $401.34 for generic mesalamine ER capsules from U.S. pharmacies, shipping included (checked Nov 11, 2026). We found no Apriso offers abroad that met our listing rules in our latest check.
- With Medicare: your cost depends on your Part D plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100 (Medicare.gov).
How much does Apriso cost in the U.S.?
| If you have | What Apriso costs | Source |
|---|---|---|
| No insurance (brand list price) | $510.31 for 120 capsules of brand Apriso (30 days at 4 a day). Pharmacies may charge more. | Texas DSHS 2026 WAC report |
| No insurance (generic mesalamine ER capsules) | FDA-approved generics list at $98 (Ascend), $100 (Alembic), $150 (Zydus, Aurobindo, Upsher-Smith), $378.14 (Teva) and $440.42 (Mylan) for 120 capsules. Ask your pharmacist for the cash price. | Texas DSHS 2026 WAC report |
| Private or employer insurance | Your copay depends on your plan's drug list. Many plans prefer the generic. | FDA Orange Book |
| Medicare Part D | Your cost depends on your plan. In 2026, deductibles are capped at $615 and yearly out-of-pocket costs for covered drugs at $2,100. | Medicare.gov |
| Medicaid | Your state Medicaid program sets any copay. Ask your pharmacist or state Medicaid office. | Medicaid.gov |
Brand Apriso lists at $510.31 for 120 capsules (30 days at the label dose) in the Texas 2026 drug price filing (Texas DSHS). FDA-approved generic mesalamine 0.375 g ER capsules list at $98 to $440.42 for the same 120 capsules. These are list prices (the maker's wholesale price before discounts); what a pharmacy charges can differ.
Apriso cost with Medicare in 2026
In 2026, Part D plans can charge a deductible of up to $615, and once your out-of-pocket spending on covered Part D drugs reaches $2,100, you pay nothing more for covered drugs for the rest of the year. What you pay for mesalamine ER capsules depends on your plan's drug list.
| Medicare Part D | What Apriso costs | Source |
|---|---|---|
| Part D deductible | No Medicare drug plan may have a deductible above $615 in 2026. Some plans have none. | Medicare.gov |
| Yearly out-of-pocket cap | Once your out-of-pocket spending on covered Part D drugs reaches $2,100 in 2026, you pay nothing more for covered drugs that year. | Medicare.gov |
Apriso coupons and savings programs
We show the programs that usually fit, cheapest first where we know the price. Private insurance means a plan through work or one you buy yourself. Programs set their own rules, so check the terms before you count on one. We don't save this choice.
eDrugSearch does not offer its own Apriso coupons. eDrugSearch has no coupons of its own. If you have Medicare, these programs can help:
- Medicare Extra Help: if you have Medicare and limited income, Extra Help lowers what you pay for prescriptions. (Social Security)
- Medicare Prescription Payment Plan: a free Medicare option that spreads your drug costs into monthly payments across the year. It doesn't lower the total, but it can make costs easier to manage. (Medicare.gov)
Is there a generic Apriso?
Yes. The FDA has approved generic mesalamine 0.375 g extended-release capsules from Mylan (first, on November 20, 2019), Zydus, Alkem, Alembic, Aurobindo, Amta (sold by Upsher-Smith), Novast (sold by Ingenus) and Annora (sold by Camber), rated equivalent to Apriso. Mylan's has been listed as on the market since November 26, 2019.
| Strength | U.S. generic | Makers | Since |
|---|---|---|---|
| 375 mg | Yes | Mylan, Zydus, Alkem (Ascend), Alembic, Aurobindo, Upsher-Smith, Ingenus, Camber; Teva (authorized generic) | Nov 26, 2019 |
Outside the U.S.: We found no mesalamine ER capsule offers from pharmacies abroad that met our listing rules in our latest check. Packs made for other markets are not FDA-approved.
Source: FDA Orange Book: mesalamine products. As of Nov 11, 2026.
Compare Apriso with similar drugs
Other medicines for inflammatory bowel disease people often compare with Apriso: Lialda, Pentasa and Asacol HD (other forms of mesalamine), and Uceris and Entocort EC (budesonide). Prices are for each drug's lowest-priced strength.
| Drug | Type | Lowest price we found | Link |
|---|---|---|---|
| Lialdamesalamine | Ulcerative colitis medicine (aminosalicylate) | $163.86 for 90 days | See prices |
| Pentasamesalamine | Ulcerative colitis medicine (aminosalicylate) | $365.13 for 90 days | See prices |
| Asacol HDmesalamine delayed-release | Ulcerative colitis medicine (aminosalicylate) | $97.43 for 90 days | See prices |
| Ucerisbudesonide | Ulcerative colitis medicine (corticosteroid) | From $6.41 per tablet | See prices |
| Entocort ECbudesonide | Crohn's disease medicine (corticosteroid) | From $0.43 per capsule | See prices |
Lowest price from licensed pharmacies shipping to the U.S., any strength: 90-day prices include shipping; prices per unit are before shipping. Only your doctor can decide whether another drug is right for you.
What is Apriso used for?
Apriso (mesalamine) is an aminosalicylate that works on the lining of the colon. According to its FDA label (DailyMed), it is used:
- To help keep ulcerative colitis in remission in adults.
The label dose is four 0.375 g capsules (1.5 g) once a day in the morning, with or without food. The capsules are swallowed whole and shouldn't be taken with antacids. The label also says to check kidney function before and during treatment, and that people allergic to salicylates (like aspirin) or aminosalicylates shouldn't use it. Your prescriber decides which medicine is right for you.
Is it safe to order Apriso from Canada?
Many Americans do, but U.S. law and customs rules apply, and for Apriso, compare the U.S. price of FDA-approved generic mesalamine ER capsules before you order. Federal law generally doesn't allow individuals to import prescription drugs, though under its personal importation policy the FDA has long used enforcement discretion for some personal-use shipments, generally no more than a three-month supply (FDA). Congress has said enforcement against individuals should focus on imports that pose a significant threat to public health (Federal Food, Drug, and Cosmetic Act section 804(j)(1), 21 U.S.C. 384(j)(1)). You need a prescription from your doctor. New U.S. Customs rules for mailed orders start January 20, 2027. We found no Apriso listing in Health Canada's drug database (Health Canada, checked 2026-11-11), so we don't expect Canadian packs; other mesalamine products sold in Canada have different strengths and release types.
Read our guide to buying prescription drugs from Canada and what the 2027 customs rules mean. Compare licensed Canadian pharmacies.
Frequently asked questions
How much is Apriso without insurance?
The U.S. list price is $510.31 for 120 capsules, a 30-day supply at the label dose ($1,530.93 for 90 days). Generic mesalamine ER capsules list from $98 for 120. In our latest check (Nov 11, 2026), U.S. pharmacies we compared charged from $1,553 for 90 days of brand Apriso and from $401.34 for the generic, shipping included. We found no Apriso offers abroad that met our listing rules.
Is there a generic Apriso?
Yes. The FDA has approved generic mesalamine 0.375 g extended-release capsules from several companies, rated equivalent to Apriso, and they've been sold in the U.S. since November 2019. Ask your pharmacist whether a generic can fill your prescription.
How much does generic Apriso cost?
In the Texas 2026 drug price filing, 120 capsules of generic mesalamine 0.375 g ER list at $98 (Ascend), $100 (Alembic), $150 (Zydus, Aurobindo, Upsher-Smith), $378.14 (Teva) and $440.42 (Mylan). Those are list prices, so ask your pharmacist for the cash price.
Is there an Apriso coupon or savings card?
eDrugSearch doesn't offer coupons of its own. FDA-approved generic mesalamine ER capsules list at $98 to $440.42 for 120 capsules, compared with $510.31 for brand Apriso, so ask your pharmacist about the generic. If you have Medicare and limited income, Extra Help can lower your costs.
Is Apriso the same as Lialda or Pentasa?
No. All three contain mesalamine, but they release it differently and come in different strengths and doses. A pharmacist can only swap Apriso for a generic rated equivalent to Apriso. Your prescriber decides which medicine is right for you.
Sources
- APRISO U.S. prescribing information (DailyMed) (Salix label, version 36, effective 2026-10-22: maintenance of remission of UC in adults; 1.5 g (four 0.375 g capsules) once daily in the morning; bottles of 120 (NDC 65649-103-02))
- Drugs@FDA: Apriso (NDA 022301) (approved October 31, 2008; Salix; prescription, rated AB)
- Texas DSHS: 2026 annual WAC report (Apriso 65649-0103-02 (120) $510.31; generic 120-count: Ascend 67877-0717-12 $98; Alembic 62332-0724-35 $100; Zydus 68382-0452-19, Aurobindo 59651-0397-08, Upsher-Smith 00832-6056-12 $150; Teva 00093-9224-89 $378.14; Mylan 00378-1375-78 $440.42)
- FDA Orange Book: mesalamine products
- Drugs@FDA: Mylan mesalamine ER capsules (ANDA 207271) (approved November 20, 2019)
- FDA NDC Directory: Mylan mesalamine 0.375 g (NDC 0378-1375) (marketing start November 26, 2019)
- FDA NDC Directory: Teva authorized generic (NDC 0093-9224) (NDA authorized generic, marketing start January 5, 2021)
- Health Canada Drug Product Database (no Apriso listing; checked 2026-11-11)
- Medicaid.gov: cost sharing
- Social Security: Medicare Extra Help
- Medicare Prescription Payment Plan
- Medicare.gov: Part D drug costs (deductible up to $615 and $2,100 out-of-pocket threshold in 2026)
- FDA: personal importation
eDrugSearch does not sell medication, and this is not medical advice. Prices change often; confirm the price at checkout. Talk with your doctor or pharmacist before changing how you get your medication.