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News on Remeron (mirtazapine)

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Remeron (mirtazapine)

Last updated on: Jan 24, 2007

What Is Mirtazapine?

Mirtazapine is a medicine that is used to treat depression.

Who Should Not Take Mirtazapine?

Never take mirtazapine if you are taking another drug used to treat depression, called a Monoamine Oxidase Inhibitor (MAOI), or if you have stopped taking a MAOI in the last 14 days. Taking mirtazapine close in time to an MAOI can result in serious, sometimes fatal, reactions, including:

High body temperature
Coma
Seizures (convulsions)

MAOI drugs include Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), Marplan (isocarboxazid), and other brands.

What Are The Risks?

Suicidal Thoughts or Actions: See FDA Alert.
Agranulocytosis. Mirtazapine may cause agranulocytosis, which is a very low number of a type white blood cells that are needed to fight infection. Call your healthcare professional if you get a fever, sore throat, mouth sores, or other signs of infection.
Severe sleepiness causing impaired judgment, thinking, and motorskills: Do not drive a car or operate dangerous machines until you know how mirtazapine affects you.
Dizziness
Increased appetite and weight gain
Increases in cholesterol, triglycerides and liver function tests
Mania: You may become hyperactive, excitable, or elated.
Seizures. You may experience a seizure (convulsion), even if you are nottaking mirtazapine close in time with a MAOI.
Sexual problems: You may have problems with impotence (erectiledysfunction), abnormal ejaculation, difficulty reaching orgasm, or decreased libido (sexual desire).
Do not drink alcohol. Alcohol can increase the impaired judgment, thinking, and motor skills that happen with mirtazapine.
Other side effects include sleepiness, nausea, increased appetite, weight gain, and dizziness
Tell your healthcare professional about all your medical conditions, especially if you have heart problems, kidney or liver problems, mania, or had a heart attack or stroke. Tell your healthcare professional if you are pregnant or plan to become pregnant. Tell your healthcare professional if you are breast-feeding or plan to breast-feed your baby.

Are There Any Interactions With Drugs Or Foods?

Mirtazapine may interact with medicines other than the ones already mentioned in this information sheet, causing serious side effects. Tell your healthcare professional about all the medicines, vitamins, and herbal supplements you take, especially Valium (diazepam) or other anti-anxiety or sleeping medicines.

How Do I Take Mirtazapine?

Mirtazapine is taken by mouth, with or without food, exactly as prescribed by your healthcare professional.
Mirtazapine orally disintegrating tablets will melt on your tongue. Do not break or split mirtazapine orally disintegrating Tablets.

This information is provided by the U.S. Food & Drug Administration.
For more information about this drug, click here.